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Aspirin molecule imprint electrochemical sensor and preparation method thereof

A technology of aspirin and molecular imprinting, applied in the direction of material electrochemical variables, etc., can solve the problems of limiting polymer pore size, difficult elution of template molecules, and poor rigidity of molecularly imprinted polymers

Inactive Publication Date: 2012-10-31
GUANGXI UNIV FOR NATITIES
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Problems solved by technology

However, these small-molecule cross-linking agents have some disadvantages, such as the poor rigidity of molecularly imprinted polymers, the imprinted holes of polymers are easy to swell and destroy, and the elution of template molecules is difficult, so a large amount of cross-linking agents needs to be added, which limits Polymer Pore Size

Method used

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  • Aspirin molecule imprint electrochemical sensor and preparation method thereof
  • Aspirin molecule imprint electrochemical sensor and preparation method thereof
  • Aspirin molecule imprint electrochemical sensor and preparation method thereof

Examples

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Embodiment 1

[0017] 1. Treatment of glassy carbon electrodes

[0018] Polish the glassy carbon electrode on the buckskin with 1.0 μm, 0.3 μm and 0.05 μm alumina powder in sequence, then put it into nitric acid with a volume ratio of 1:1 and sonicate for 5 minutes, then put it into absolute ethanol for 5 minutes, and finally Ultrasonic cleaning with ultrapure water.

[0019] 2. Preparation of aspirin molecularly imprinted electrochemical sensor

[0020] To 2.0ml solvent acetonitrile, add 0.2mmol template molecule aspirin, 0.8mmol functional monomer acrylamide, 0.8mmol crosslinking agent maleic rosin ethylene glycol acrylate and 0.08mmol initiator azobisisobutyronitrile , every time a chemical reagent is added, ultrasonically dissolve for 5 minutes;

[0021] After the mixture is dissolved, take 2 μL of the mixture in step and apply it on the surface of the treated clean and smooth glassy carbon electrode. After standing for half an hour, place the modified electrode in a vacuum drying o...

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Abstract

The invention discloses an aspirin molecule imprint electrochemical sensor and a preparation method thereof. The molecule imprint technology is combined with the electroanalysis chemical detection technology for use, aspirin serves as template molecules, acrylamide serves as functional monomers, and rosin, one of the characteristic resources in Guangxi province, is tightly combined and serves as the raw material for synthetizing maleated rosin acrylic acid glycol ester which is used as a cross linker. The aspirin molecule imprint electrochemical sensor can be used for measuring content of aspirin, and shows better selective identification performance; and an electrochemical analysis method for measuring aspirin based on the sensor is simple and practical, and overcomes the defect that the traditional method is complicated.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to an aspirin molecularly imprinted electrochemical sensor and a preparation method thereof. Background technique [0002] Aspirin is an antipyretic and analgesic drug with good antipyretic and analgesic effects. It is used to treat colds, fever, headache, toothache, joint pain, rheumatism, and can also inhibit platelet aggregation. It is used to prevent and treat ischemic heart disease. disease, angina pectoris, cardiopulmonary infarction, and cerebral thrombosis, it is also effective in angioplasty and bypass grafting. In clinical use, the main side effect of aspirin is gastrointestinal adverse reactions. Therefore, it is important to study a highly selective detection method for aspirin. [0003] Molecular imprinting technology uses the target molecule to be tested as a template molecule, combining structurally complementary functional monomers with the template...

Claims

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Application Information

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IPC IPC(8): G01N27/48C08F222/14C08F220/56C08J9/26
Inventor 谭学才孙月新余会成刘绍刚黄在银雷福厚
Owner GUANGXI UNIV FOR NATITIES
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