Berberine electrostatic composite and preparation method of berberine electrostatic composite

Abstract

The invention discloses a berberine electrostatic composite and a preparation method of the berberine electrostatic composite, which are applied to medical and health industries. The berberine electrostatic composite is prepared from anionic surfactant and berberine or berberine salt by compositing; the molar ratio of the anionic surfactant to the berberine or berberine salt is 1 to 0.5-10; the molar ratio of anion to the berberine salt is 1 to 1; the anionic surfactant is one or more of alkyl sulfate or alkyl sulfonate or fatty acid salt; the alkyl sulfate is one or more of sodium cholesteryl sulfate, lauryl sodium sulfate and deoxysodium cholate; the alkyl sulfonate is one or more of sodium heptanesulfonate and sodium dodecyl sulfate; the fatty acid salt is one or more of sodium caprate and sodium enanthate, and the berberine and berberine salt are obtained by chemical synthesis or by extracting traditional Chinese medicine. The berberine is prepared into the berberine electrostatic composite to increase the biological membrane penetrating ability of the berberine and improve the oral bioavailability of the berberine, and the berberine electrostatic composite plays a significant treatment role on important chronic metabolic disorder diseases such as diabetes mellitus, complication of the diabetes mellitus, hyperlipidemia and the like.

Description

technical field [0001] The invention relates to a berberine electrostatic complex in the medical and health industry and a preparation method thereof. Background technique [0002] Berberine, English name Berberine, Chinese alias berberine, berberine, berberine, a common isoquinoline alkaloid, it exists in many plants of four families and ten genera including Berberidaceae. In 1826 M.-E. Chavalier and G. Peltin obtained for the first time from the bark of Xanthoxylonclava. Berberine is a quaternary ammonium alkaloid, which has antibacterial effects on hemolytic streptococcus, Staphylococcus aureus, Neisseria gonorrhoeae, Freund's, Shigella dysenteriae, etc., and can enhance the phagocytosis of leukocytes. Yersinia pestis also has different degrees of inhibition, and it also has inhibitory effect on amoebic bacteria in rats. Berberine has anti-curare effect on animals, and has peripheral antihypertensive and antipyretic effects. Berberine hydrochloride (commonly known as b...

AI Technical Summary

Problems solved by technology

Most of the absorption enhancers have a certain cytotoxic effect, causing a certain degree of damage to the gastrointestinal mucosa or cell membrane, intestinal endotoxins and other chemical substances may be absorbed into the blood circulation and cause side effects, and the absorption enhancer itself In vivo pharmacokinetics and long-term toxicity are not yet clear, and there are few products that actually use accelerators

After literature search, the anionic surfactant with absorption-promoting effect and the positively charged quaternary ammonium alkaloid berberine are combined to form a berberine complex through electrostatic interaction to improve its oral bioavailability and expand the berberine complex. There is no report on the relevant research and application of medicinal value

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