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A kind of preparation method and application of polyether antibiotic unsaturated fatty acid complex oil solution

A technology of unsaturated fatty acid and polyether antibiotics, which is applied in the direction of active ingredients of heterocyclic compounds, medical preparations of non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problems of low solubility, small content, and quantitative administration Difficulty and other issues

Active Publication Date: 2021-05-11
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It overcomes the defects of small drug content, low solubility, poor dilution stability and difficult quantitative administration of commercially available dosage forms

Method used

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  • A kind of preparation method and application of polyether antibiotic unsaturated fatty acid complex oil solution
  • A kind of preparation method and application of polyether antibiotic unsaturated fatty acid complex oil solution
  • A kind of preparation method and application of polyether antibiotic unsaturated fatty acid complex oil solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] prescription:

[0050]

[0051] preparation:

[0052] Take 150mg of linoleic acid in a vial, add 50mg of salinomycin sodium, vortex slightly, fill the vial with nitrogen and seal it, control the temperature of the water bath at 30°C and magnetically stir for 24 hours until the system is clear and transparent to obtain salinomycin sodium Linoleic Acid Complex. Add the prepared compound to the prescribed amount of ethyl oleate, RH 40 and propylene glycol, and stir evenly until it becomes a clear and transparent liquid, and then the oil solution of salinomycin sodium linoleic acid compound is obtained.

Embodiment 2

[0054] prescription:

[0055]

[0056] preparation:

[0057] Take 250mg of arachidonic acid in a vial, add 50mg of Hainanmycin, vortex slightly, fill the vial with nitrogen and seal it, control the temperature of the water bath at 35°C and sonicate for 8 hours until the system is clear and transparent to obtain Hainanmycin Peanut IV Acid complex. Add the prepared compound to the prescribed amount of MCT, EL 35 and isopropanol, and stir evenly until it becomes a clear and transparent liquid, and the oil solution of Hainanmycin arachidonic acid compound is obtained.

Embodiment 3

[0059] prescription:

[0060]

[0061] preparation:

[0062] Take 250mg of oleic acid in a vial, add 150mg of maduramicin ammonium, vortex briefly, fill the vial with nitrogen gas and seal it, control the temperature of the water bath at 40°C and sonicate for 8 hours until the system is clear and transparent to obtain maduromicin ammonium Oleic Acid Complex. Add the obtained compound to the prescribed amount of MCT, EL35, Tween 80 and propylene glycol, and stir evenly until it becomes a clear and transparent liquid, and then the oil solution of maduromycin ammonium oleic acid compound is obtained.

[0063] Take respectively 5 mg of maduromycin ammonium, oleic acid, the maduromycin ammonium oleic acid complex prepared in this embodiment and the physical mixture (mass ratio 3:5) of maduromycin ammonium and oleic acid in a crucible, Take 40°C as the initial temperature, then increase the temperature to 350°C at a rate of 10°C / min, use a blank crucible clamp as a blank contro...

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PUM

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Abstract

The invention discloses a preparation method and application of polyether antibiotic unsaturated fatty acid complex oil solution. The polyether antibiotic unsaturated fatty acid complex oil solution mainly consists of polyether antibiotic unsaturated fatty acid complex, oil phase, emulsifier and co-emulsifier; the mass ratio of oil phase to compound is 1:0.5-1:2; the mass ratio of oil phase to emulsifier is 1:1-1:4; oil phase and co-emulsifier The mass ratio is 2:1‑1:1. The polyether antibiotic unsaturated fatty acid complex oil solution prepared by the invention can overcome the poor water solubility of polyether antibiotics, and is a kind of medicine with high drug loading capacity, good dilution stability, strong storage stability, strong water dispersibility, and low toxicity and side effects. The polyether antibiotic unsaturated fatty acid complex oil solution has a simple preparation process, is suitable for large-scale industrial production, and can be effectively used in the preparation of veterinary anticoccidial drug dosage forms.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a preparation method and application of a polyether antibiotic unsaturated fatty acid complex oil solution. Background technique [0002] Polyether antibiotics have strong antibacterial activity against Gram-positive bacteria and various anaerobic bacteria, and are widely used as coccidiosis drugs in animal husbandry. characteristics such as drug resistance. There is a carboxyl group and multiple ether bonds in the structure of this type of drug, which is easy to combine with metal cations. After entering the coccidia cells, the concentration of ions inside and outside the cells will change, thereby affecting the osmotic pressure, and finally disintegrating the coccidia cells, so it is not easy to produce drug resistance. However, the safety range of its administration is narrow, and poisoning phenomena such as growth inhibition and decreased feed conversion rate ofte...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K9/08A61K31/351A61K31/7048A61K31/35A61K47/54A61P33/02
CPCA61K9/08A61K9/1075A61K31/35A61K31/351A61K31/7048A61K47/542A61P33/02
Inventor 周建平丁杨彭晋
Owner CHINA PHARM UNIV
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