Antihypertensive active rapeseed peptide and preparation method and application thereof

Abstract

The invention provides an antihypertensive active rapeseed peptide and a preparation method and application thereof. The preparation method of the antihypertensive active rapeseed peptide includes obtaining crude extract of the antihypertensive active rapeseed peptide by pepsin and pancreatic enzymatic hydrolyzed rapeseed protein, and obtaining the antihypertensive active rapeseed peptide by refining. The invention further provides the antihypertensive active rapeseed peptide prepared by the method and application thereof. Sources of rapeseed meal for preparing the antihypertensive active rapeseed peptide are extensive, production process is simple, low in cost and environment-friendly, and the method is suitable for industrialization. The antihypertensive active rapeseed peptide causes low gastrointestinal reaction, is capable of resisting hydrolysis of human digestive enzymes, and has good antihypertensive effect by actively reacting to target organs. The antihypertensive active rapeseed peptide is capable of inhibiting not only ACE (angiotensin converting enzyme) but also renin activity, is capable of avoiding alternative pathways of a RAS (renin angiotensin system) activated by taking antihypertensive drug, ACE inhibitor, for long, and has bright application prospect in terms of lowering blood pressure.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the antihypertensive rapeseed active peptide, its preparation method and application. Background technique [0002] my country is the country with the largest rapeseed production in the world, with an annual output of nearly 12 million tons. Rapeseed meal is the main by-product of rapeseed oil processing, accounting for 65% of the total rapeseed, which contains 35% to 42% protein. The amino acid composition of rapeseed protein is reasonable, and the content of lysine, cystine and methionine is relatively high, so it is an excellent vegetable protein. The development and utilization of rapeseed protein resources has great social significance and good economic benefits for the effective use of our country's plant protein resources and the improvement of the nutritional level of our people. [0003] At present, there are about 200 million hypertensive patients in my country, and there ...

AI Technical Summary

Problems solved by technology

[0003] At present, there are about 200 million hypertensive patients in my country, and there are still 10 million new people every year. The existing blood pressure lowering drugs have the following problems: On the one hand, long-term use of the existing blood pressure lowering drugs will cause many side effects to the body, especially It has great damage to the digestive tract system; on the other hand, the target of most antihypertensive peptide research is angiotensin transferase (ACE), but long-term use of antihypertensive drugs ACE inhibitors will activate angiotensin The bypass pathway of the RAS system, thereby affecting the clinical treatment of hypertension

However, there are fewer blood pressure-lowering drugs based on renin inhibitors

Images