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Compound enrofloxacin pellets and preparation method thereof

A technology of enrofloxacin pellets and compound enrofloxacin, which is applied in the direction of bulk delivery, active ingredients of heterocyclic compounds, antibacterial drugs, etc., can solve the problems of increasing the number of medications, high labor intensity, and poor palatability , to achieve the effects of reduced dosage, uniform particle size and convenient medication

Inactive Publication Date: 2013-05-01
GUANGDONG WENS DAHUANONG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Clinically, enrofloxacin and amoxicillin are commonly used alone. In order to achieve the therapeutic effect, it is necessary to increase the dose or prolong the use time of the single drug, so that drug resistance and drug residues are likely to occur, and the single drug is time-consuming and laborious. If the injection is more labor-intensive and stressful
In addition, enrofloxacin has a bitter taste and poor palatability, which affects animal feed intake, and the rapid excretion of amoxicillin needs to increase the number of medications

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A compound enrofloxacin pellets, comprising a coating and a drug-loaded pill core, the drug-loaded pill core is a particle of no more than 30 mesh in size, and the drug-loaded pill core contains the following components by weight percentage:

[0039] Amoxicillin 20%;

[0040] Enrofloxacin 10%;

[0041] Starch 37%;

[0042] Microcrystalline cellulose 20%;

[0043] Sodium carboxymethyl starch 8%;

[0044] Granulation binder 5%;

[0045] Wherein, the granulation binder is polyvinylpyrrolidone.

[0046] The coating weight is 5% of the total weight of the compound enrofloxacin pellets, and the coating contains the following components in weight percentage:

[0047] Hydroxypropyl methylcellulose 7%;

[0048] Talc 4%.

[0049] The preparation method of the compound enrofloxacin pellets includes the following specific steps:

[0050] Step 1) Weigh 5g of polyvinylpyrrolidone and dissolve it in ethanol or hot water to obtain a granulating adhesive;

[0051] Step 2) Weigh the following components a...

Embodiment 2

[0055] A compound enrofloxacin pellets, comprising a coating and a drug-loaded pill core, the drug-loaded pill core is a particle of no more than 30 mesh in size, and the drug-loaded pill core contains the following components by weight percentage:

[0056] Amoxicillin 30%;

[0057] Enrofloxacin 15%;

[0058] Starch 30%;

[0059] Microcrystalline cellulose 15%;

[0060] Sodium carboxymethyl starch 5%;

[0061] Granulation binder 5%;

[0062] Wherein, the granulation binder is sodium carboxymethyl cellulose.

[0063] The coating weight is 5% of the total weight of the compound enrofloxacin pellets, and the coating contains the following components in weight percentage:

[0064] Hydroxypropyl methylcellulose 10%;

[0065] Talc 2%.

[0066] The preparation method of the compound enrofloxacin pellets includes the following specific steps:

[0067] Step 1) Weigh 5 g of sodium carboxymethyl cellulose and dissolve it in hot water to obtain a granulating binder;

[0068] Step 2) Weigh the following com...

Embodiment 3

[0072] A compound enrofloxacin pellets, comprising a coating and a drug-loaded pill core, the drug-loaded pill core is a particle of no more than 30 mesh in size, and the drug-loaded pill core contains the following components by weight percentage:

[0073] Amoxicillin 10%;

[0074] Enrofloxacin 5%;

[0075] Starch 43%;

[0076] Microcrystalline cellulose 25%;

[0077] Sodium carboxymethyl starch 10%;

[0078] Granulation binder 7%;

[0079] Wherein, the granulation binder is starch.

[0080] The coating weight is 2% of the total weight of the compound enrofloxacin pellets, and the coating contains the following components in weight percentage:

[0081] Hydroxypropyl methylcellulose 2%;

[0082] Talc powder 6%.

[0083] The preparation method of the compound enrofloxacin pellets includes the following specific steps:

[0084] Step 1) Weigh 7g of starch and dissolve it in hot water to obtain granulated adhesive;

[0085] Step 2) Weigh the following components according to the following weights: ...

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Abstract

The invention relates to compound enrofloxacin pellets and a preparation method of the compound enrofloxacin pellets, wherein the enrofloxacin pellets comprise coatings and medicine-carrying pill cores; the coatings wrap the medicine-carrying pill cores; the medicine-carrying pill cores are prepared by the following steps that: amoxicillin and enrofloxacin are mixed with starch, microcrystalline cellulose, carboxymethyl starch and the like uniformly; an appropriate amount of pelleting adhesive is added in the mixture to prepare the soft material, the soft material is added into an extrusion pelleter to be extruded out, the extruded material is placed in a shot blasting machine to prepare the medicine-carrying pill cores. Then, the pill cores are placed into a fluidized bed to be dried andthen sieved; finally the sieved pill cores are placed into the fluidized bed, coating liquid is injected for coating, fluidized drying is then carried out after the coating, and then the finished product is obtained. According to the invention, both the amoxicillin and enrofloxacin are used, so that double effects are achieved, the medicine administration frequency and dose are reduced, and the pellets are easy to take only by stirring, and feed intake of animals is not influenced. In addition, the preparation method of the compound enrofloxacin pellets has simple process steps and low energyconsumption, is safe to produce and easy to implement, and the prepared pellets have uniform granularity.

Description

Technical field [0001] The invention belongs to the field of veterinary drug preparations, and specifically relates to compound enrofloxacin pellets and a preparation method thereof. Background technique [0002] Enrofloxacin is the first fluoroquinolones (Fluroquinolones) drug for livestock and poultry. It has a broad-spectrum bactericidal effect and is effective against bacteria in both the stationary and growing phases. It has strong bactericidal activity, wide distribution in the body, and other antibacterial drugs. It has no cross-resistance and other characteristics, and has good antibacterial effect on a variety of Gram-negative bacilli and cocci, including Pseudomonas aeruginosa, Klebsiella, Escherichia coli, Enterobacter, Shigella, Salmonella , Aeromonas, Haemophilus, Vibrio, Proteus, etc., it is also effective against Brucella, Pasteurella, Erysipelas, Staphylococcus, etc., and also effective for Mycoplasma and Chlamydia ; It has good effect on synergistic sulfa-resist...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/496A61K9/16A61P31/04A61K31/43
Inventor 刘小艳方炳虎陈瑞爱
Owner GUANGDONG WENS DAHUANONG BIOTECH
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