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Separated water suspension medicine composed of hydrocortisone butyrate and water containing accessories and used for treating dermatosis

A technology for hydrocortisone butyrate and skin diseases, which can be applied to skin diseases, drug combinations, organic active ingredients, etc. It can solve the problems of unstable particles and the inability to ensure long-term storage of particle suspensions, so as to reduce waste and ensure Suspension stability, ease of use

Inactive Publication Date: 2012-07-04
TIANJIN JINYAO GRP
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] How to solve the problem of particle instability in microparticle suspensions has always been one of the problems that need to be solved in pharmacy, but whether by adding excipients or improving the particle structure, it is impossible to ensure long-term preservation of microparticle suspensions, especially for skin products. Suspensions are multi-use and are more likely to have the above problems

Method used

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  • Separated water suspension medicine composed of hydrocortisone butyrate and water containing accessories and used for treating dermatosis
  • Separated water suspension medicine composed of hydrocortisone butyrate and water containing accessories and used for treating dermatosis
  • Separated water suspension medicine composed of hydrocortisone butyrate and water containing accessories and used for treating dermatosis

Examples

Experimental program
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Effect test

preparation example Construction

[0028] 1. Preparation of drug particles for transdermal absorption

[0029] The capsules packed with the pharmaceutical microparticles obtained in Examples 1 to 10 are plant capsules, and the capsules are packed in aluminum foil blisters after packing.

Embodiment 1

[0031] Dissolve 0.2g hydrocortisone butyrate in ethanol, filter, spray-dry the filtrate, micronize the particle size to 3μm, pass through a 200-mesh sieve for 3 times, mix well, sterilize, and pack in No. 3 capsules, each Capsules have hydrocortisone butyrate 2mg. Electron microscope observation shows that the particles are spherical.

[0032] The process conditions are: the inlet temperature is 105°C, the outlet temperature is 68°C, the air flow rate is 90%, the inner diameter of the nozzle outlet is 0.1cm, the air flow rate of the nozzle is 800ml / min, and the injection speed is 50mL / h

Embodiment 2

[0034] Dissolve 1g of hydrocortisone butyrate in ethanol, filter, spray-dry the filtrate, micronize it to make the particle size reach 3μm, mix it with a 200-mesh sieve for 3 times, sterilize it, and pack it into No. 3 capsules. Capsules have hydrocortisone butyrate 1mg. Electron microscope observation shows that the particles are spherical.

[0035] The process conditions are as follows: inlet temperature is 105°C, outlet temperature is 70°C, air flow rate is 90%, nozzle outlet inner diameter is 0.1cm, nozzle air flow rate is 800ml / min, and sample injection speed is 50mL / h.

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Abstract

The invention discloses a separated water suspension medicine composed of hydrocortisone butyrate and water containing accessories and used for treating dermatosis. The independently packaged hydrocortisone butyrate with D90 particle size of 0.1-10mu m and the independently packaged water containing one or several skin medicinal accessories together form the independently packaged water-insoluble skin medicine with the D90 particle size of 1-10mu m preferably, wherein the particle shape is sphere or similar sphere.

Description

Technical field: [0001] The invention relates to a medicine for skin, which is composed of separately packaged water-insoluble hydrocortisone butyrate, and separately packaged water containing one or several skin medicine auxiliary materials. Background technique: [0002] Skin inflammations such as eczema, allergic dermatitis, atopic dermatitis, and urticaria are caused by allergic reactions caused by certain allergens. [0003] In the skin drug delivery system, the skin is the main barrier for drugs to enter the body. Studies have found that only a few drugs have excellent skin permeability, and most drugs are not easy to pass through the effective and selective barrier of human skin. Drugs with higher solubility cross the epidermis more easily. In the treatment of skin diseases, the most common type of preparation is transdermal drug delivery, transdermal drug delivery system or transdermal drug delivery system (transdermal thrapeutic systems, transdermal drug delivery s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/573A61P17/00A61P17/08A61P37/08
Inventor 孙亮陈松赵琳
Owner TIANJIN JINYAO GRP
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