Preparation method of hexafluoroisopropyl methyl ether

Abstract

The invention discloses a preparation method of 1,1,1,3,3,3-hexafluoroisopropyl methyl ether. In the preparation method, hexafluoroisopropyl alcohol and halogenated methane are taken as raw materials to synthesize the 1,1,1,3,3,3-hexafluoroisopropyl methyl ether under the action of a base catalyst, wherein, the halogenated methane has the following general formula: CH3X, wherein, X is chosen from Cl, Br or I. The preparation method has the advantages of available raw materials and mild preparation process, and is simple in operation; and the obtained 1,1,1,3,3,3-hexafluoroisopropyl methyl ether can be taken as an intermediate to synthesize the methyl fluoride-1,1,1,3,3,3- hexafluoroisopropyl ether.

Description

technical field [0001] The invention relates to a preparation method of 1,1,1,3,3,3-hexafluoroisopropyl methyl ether. Background technique [0002] 1,1,1,3,3,3-Hexafluoroisopropyl methyl ether, CAS registration number: 13171-18-1, molecular formula C 4 h 4 f 6 O, with a molecular weight of 182.06, a boiling point of 50.9°C, a relative density of 1.030-1.038, a refractive index of 1.284, a saturated vapor pressure (25°C) of 36.1KPa, low toxicity, flammable in case of an open flame, a gas with low thermal conductivity and high chemical stability high. It is the key raw material for the synthesis of fluoromethyl-1,1,1,3,3,3-hexafluoroisopropyl ether, while fluoromethyl-1,1,1,3,3,3-hexafluoroisopropyl Commonly known as sevoflurane or sevoflurane, base ether is a new type of inhaled general anesthetic, clinically characterized by short anesthesia and recovery time, less toxic and side effects on the kidneys, and reduced cerebrovascular pressure, brain metabolism, and brain ox...

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Problems solved by technology

[0005] (1) U.S. Patent US3346448 and British Patent GB1250928 have reported the use of dimethyl sulfate to react with hexafluoroisopropanol under the effect of alkali, and the method is more convenient to synthesize hexafluoroisopropyl methyl ether, but the product yield is not high High, and the use of highly toxic raw materials at the same time puts forward higher requirements for the operating environment and the treatment of three wastes;

[0006] (2) Chinese patent CN101544547 reports the use of dimethyl carbonate to react with hexafluoroisopropanol under the action of a base. Although this method avoids the use of highly toxic raw material dimethyl sulfate, the operating temperature is about 200°C and requires To stainless steel autoclave, the operating cost is higher

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