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Method for synthesizing taurine

A synthesis method and taurine technology, applied in the fields of biochemistry and molecular biology, can solve the problems of environmental protection management and burden of side reactions

Inactive Publication Date: 2013-10-30
薛荔
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of this invention is to provide a kind of synthetic method of taurine, which solves the defects such as easy generation of side reactions under high temperature and high pressure conditions existing in the existing ammonolysis method and bringing burdens to environmental protection, and its raw material sources are sufficient and the price is low. Relatively cheap, mild reaction conditions, recycling of by-products, conducive to environmental protection, relatively high yield

Method used

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preparation example Construction

[0021] The content of the present invention will be described in detail below according to specific embodiments. The synthetic method operating steps of this taurine are as follows:

[0022] Step 1 Addition reaction

[0023] Put ammonium chloride and water in the reaction kettle, inject ethylene oxide under stirring, gradually raise the temperature to react, and control it at 50-60°C, and react under the pressure ≤ 0.1Mpa until the ethylene oxide is basically absorbed, that is, the reaction is completed. Nitrogen was introduced into the kettle to blow off the residual ethylene oxide and recovered, and then the water was removed under reduced pressure and filtered at normal temperature. Rinse with methanol, pump dry, and vacuum-dry at 50°C under temperature control to obtain monoethanolamine hydrochloride. Used ammonium chloride, water, the weight ratio of oxirane is ammonium chloride: water: oxirane=1.07: (0.725~0.875): 1.

[0024] Step 2 Chlorination reaction

[0025] Dis...

Embodiment １

[0032]Add 175ml of water and 214g of ammonium chloride into a 1 liter reaction kettle with a stirring device, and gradually inject 200g of ethylene oxide under stirring to start the reaction, and the temperature is also rising, stirring until the temperature is 50-60°C, The pressure of the reactor is controlled at ≤0.1Mpa until the ethylene oxide is basically absorbed, that is, the reaction is complete. After the reaction was completed, nitrogen gas was introduced to remove residual ethylene oxide, and the residual ethylene oxide was recovered. The water was removed under reduced pressure and filtered at room temperature, rinsed with a small amount of methanol, sucked dry, and vacuum-dried at 50°C to obtain about 220 grams of monoethanolamine hydrochloride. Then monoethanolamine hydrochloride was dissolved in 268 grams of chloroform solvent, 295 grams of thionyl chloride was added dropwise and reacted at 70°C for 5 hours, and the chloroform solvent was recovered to obtain about...

Embodiment ２

[0034] Add 165ml of water into a 1-liter reaction kettle, add 214g of ammonium chloride, gradually inject 200g of ethylene oxide under stirring, start the temperature rise and control it at 50-60°C, and the pressure is 0.1Mpa. Residual ethylene oxide, remove the water under reduced pressure and cool down to room temperature, discharge and filter, rinse with a small amount of methanol, drain and dry to obtain about 215 grams of monoethanolamine hydrochloride, and then dissolve monoethanolamine hydrochloride in 262 grams of chloroform solvent, Drop in 283 grams of thionyl chloride and react at 70°C for 5 hours, recover the chloroform solvent to obtain the intermediate product 2-chloroethylamine hydrochloride, and the obtained intermediate product is made into 2-chloroethylamine hydrochloride with a concentration of 80%. Aqueous solution, slowly add 284 grams of 30% sodium sulfite solution containing 9 grams of isopropanol to react at 80 ° C, after the reaction is completed, drop ...

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Abstract

The invention discloses a method for synthesizing taurine, which is to prepare taurine by preparing ethanolamine hydrochloride through addition reaction of ethylene oxide and industrial ammonium chloride which is byproduct from alkali making plants and by chlorination, sulfonation and neutralization. The method solves the inconvenience of high-temperature and high-pressure reaction of ethoxy sulfonate and liquid ammonia and side reaction forming imino diethyl sulfonate; in the chlorination, thionyl chloride is used as a chlorinating agent to ensure high conversion rate, byproducts HCl and SO2 both are gases which escape naturally and easy to remove by volatilization, the SO2 and HCl by products can be used to make sodium sulfite and hydrochloric acid, which are to be used in following sulfonation and neutralization reactions, and the method thus is basically in accordance with a philosophy of circular economy; in chlorination, an inhibitor is added to prevent self-phase oxidation-reduction reaction of the sulfite and extra consumption brought by the self-phase oxidation-reduction reaction of the sulfite; in reactions in all reactions, a theoretical amount is reached approximately; and sodium chloride is almost the only byproduct, and thus the environment protection and remediation pressures of enterprises are relieved.

Description

technical field [0001] The invention relates to a new synthetic process for raw materials such as medicine and food additives, in particular to a synthetic method for taurine as a high-quality nutrient. Belongs to the field of biochemistry and molecular biology. Background technique [0002] Taurine, also known as 2-aminoethanesulfonic acid, has unique pharmacological and nutritional health effects, and can be widely used as a raw material in medicine and food additives. As a raw material, taurine can be used for choleretic, liver protection, detoxification, anti-inflammatory, antipyretic, sedative, hypoglycemic and treatment of various eye diseases; it can be used as a food additive in dairy products, beverages, compound monosodium glutamate and soybean products , to enhance the body's immune ability; as a food nutrition enhancer, add an appropriate amount of taurine to milk and milk powder, its nutritional value is close to that of breast milk, especially for fetuses, inf...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C309/14C07C303/18
Inventor 薛守礼薛芳薛荔
Owner 薛荔
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