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A kind of veterinary pefloxacin mesylate pellets and preparation method thereof

A technology of pefloxacin mesylate and pellets, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., which can solve the problem of gastric mucosa irritation and strong powder irritation To achieve the effects of good drug stability, small gastrointestinal irritation and high drug bioavailability

Inactive Publication Date: 2011-11-30
WUHAN HUAYANG ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pefloxacin mesylate raw material is hygroscopic, the powder is highly irritating, and oral administration has a stimulating effect on the gastric mucosa.

Method used

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  • A kind of veterinary pefloxacin mesylate pellets and preparation method thereof
  • A kind of veterinary pefloxacin mesylate pellets and preparation method thereof
  • A kind of veterinary pefloxacin mesylate pellets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Put 40kg of pefloxacin mesylate powder, 5kg of ethyl cellulose and 100L of cyclohexane in an organic solution reactor, reflux at 80°C for 1.5h, and then reduce the temperature by 2°C every 5min to 25 ℃, pefloxacin mesylate powder is wrapped in the wall to form 40-200 mesh pellets, and after vacuum drying, the required pefloxacin mesylate pellets are obtained.

Embodiment 2

[0027] Put 35kg of pefloxacin mesylate powder, 3kg of ethyl cellulose, 3kg of carboxymethyl cellulose and 100L of cyclohexane in an organic solution reaction kettle, reflux at 85°C for 2h, and then lower the temperature by 1°C every 5min. The temperature is lowered to 30°C, and the pefloxacin mesylate powder is wrapped in the wall to form pellets with a mesh size of 40 to 200. After vacuum drying, the desired pefloxacin mesylate pellets are obtained.

Embodiment 3

[0029] Put 38kg of pefloxacin mesylate powder, 3kg of ethyl cellulose, 3kg of carboxymethyl cellulose, 1.5kg of polypropylene and 100L of cyclohexane into an organic solution reaction kettle, reflux at 80°C for 1h, and then The temperature was lowered to 35°C at a rate of 3°C in 5 minutes, and the pefloxacin mesylate powder was wrapped in the wall to form pellets of 40 to 200 meshes. After vacuum drying, the desired pefloxacin mesylate was obtained. pellets.

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Abstract

The invention relates to animal pefloxacin mesylate pellets, and a preparation method thereof. The preparation method of the animal pefloxacin mesylate pellets comprises steps that: pefloxacin mesylate powder, a wall material which is a high-molecular material, and cyclohexane are placed in an organic solvent reaction vessel, and reflux is carried out for 1 to 2 hours under a temperature of 80 to85 DEG C; the temperature of the materials is reduced to 25 to 35 DEG C at a speed of 1 to 3 DEG C per 5 minutes, such that pefloxacin mesylate is coated with the wall, and pellets with sizes of 40 to 200 meshes are formed; the pellets are vacuum-dried, such that the animal pefloxacin mesylate pellets are obtained. According to the animal pefloxacin mesylate pellets provided by the invention, a high-molecular material or polymer is coated on the surface of the medicine, such that tiny sealed capsules are obtained, and the capsules serve as covers or protective films. Therefore, the bitter taste of the medicine can be covered; medicine stability can be improved; and volatilization of volatile medicines can be controlled. The animal pefloxacin mesylate pellets provided by the invention has advantages of convenient use, simple production technology, low cost, high medicine bioavailability, low irritation to intestines and stomach, and good medicine stability.

Description

technical field [0001] The invention relates to a pefloxacin mesylate pellet for veterinary use and a preparation method thereof. Background technique [0002] Pefloxacin is a new fluoroquinolone antibacterial drug against G- and G+ bacteria, including Escherichia coli, Salmonella, Klebsiella, Proteus, Haemophilus, Pasteurella, Campylobacter, Pseudomonas Monascus and Erysipelas suis, Staphylococcus aureus, meningococcus, and mycoplasma infection all have effects. Pefloxacin is superior to cephalexin and norfloxacin in the treatment of respiratory tract, digestive tract and urinary tract infections; it has extremely strong effects on chicken Escherichia coli, Staphylococcus aureus, mycoplasma, Salmonella pullorum, and pullorum in piglets. Antibacterial effect. Similar to other fluoroquinolones, this product is a fungicide. Its antibacterial mechanism is to specifically act on the A subunit of DNA topoisomerase II, which hinders DNA replication, affects the processes of DNA...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/496A61K47/36A61K47/32A61P31/04
Inventor 马立保张金林胡晓芬马红伟
Owner WUHAN HUAYANG ANIMAL PHARMA
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