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Traditional Chinese medicine compound preparation used for treating diabetic nephropathy, and preparation method thereof

A technology of diabetic nephropathy and traditional Chinese medicine, which is applied in the field of compositions for treating diabetic nephropathy, can solve the problems of unsatisfied clinical needs, inability to guarantee the health and life of patients, and great difficulty, and achieve the effects of convenient quality control, less toxic and side effects, and specific drug efficacy

Active Publication Date: 2012-10-17
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the multiple occurrence and high hazards of diabetic nephropathy, the state has clearly listed diabetes and its complications as one of the major diseases and major new drug research directions. However, due to the difficulty, there are few mature clinical products specifically for diabetic nephropathy at present. Application, the common Chinese medicine varieties are mainly drugs for the simple treatment of diabetes, there is a gap in the market, the clinical needs cannot be met, and the health and life of patients cannot be guaranteed.

Method used

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  • Traditional Chinese medicine compound preparation used for treating diabetic nephropathy, and preparation method thereof
  • Traditional Chinese medicine compound preparation used for treating diabetic nephropathy, and preparation method thereof
  • Traditional Chinese medicine compound preparation used for treating diabetic nephropathy, and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Raw material preparation:

[0034] Take 10kg of Coptis rhizome, extract with 10 times the amount of 70% ethanol under reflux three times, each time for 1.5h, filter, combine the three extracts, recover the solvent, concentrate to 50°C with a relative density of about 1.10, reduce pressure or spray dry to obtain the extract thing I;

[0035] Anemarrhena 5kg, Radix Astragali 10kg, Salvia miltiorrhiza 8kg, Epimedium 5kg, Leech 6kg and Motherwort 6kg are extracted three times with water, the amount of solvent used is 10 times the weight of the medicinal materials, the extraction time is 1.5 hours, filtered, the three extracts are combined and concentrated, concentrated The relative density is 1.15 at 50°C, add ethanol to ethanol concentration to 80%, let it stand overnight, filter, combine the filtrates, recover the ethanol until it has no alcohol smell, concentrate to 50°C and the relative density is 1.10, reduce pressure or spray dry , to obtain extract II;

[0036] The...

Embodiment 2

[0038] Compound preparation formula of the present invention is made up of following components:

[0039] Compound Extract 200.0g

[0040] Starch + Lactose + Mannitol 190.0g

[0041] Citric acid 1.0g

[0042] Magnesium Stearate + Talc 5.0g

[0043]Ethanol solution of polyvinylpyrrolidone (3%) appropriate amount

[0044] Makes 1000 capsules in total

[0045] It is prepared by wet granulation and then filled with capsules. The specific preparation method is as follows: weigh the compound extract, lactose+starch+mannitol, and citric acid according to the amount, mix them uniformly and pass through an 80-mesh sieve, and add the ethanol solution of polyvinylpyrrolidone ( 3%) appropriate amount of granulation, after drying at 50°C for 1.0 hour, pass through a 20-mesh sieve for granulation, then add a lubricant, pack into capsules, and obtain the compound capsule of the present invention.

Embodiment 3

[0047] Compound preparation formula of the present invention is made up of following components:

[0048] Compound Extract 200.0g

[0049] Lactose+dextrin 190.0g

[0050] Micronized silica gel + sucrose stearate 8.0g

[0051] Citric acid 1.0g

[0052] Ethanol solution of ethyl cellulose (1%)+

[0053] Ethanol solution of polyvinylpyrrolidone (1%) appropriate amount

[0054] Makes 1000 capsules in total

[0055] Weigh the compound extract, lactose+dextrin, and citric acid according to the amount, mix them uniformly and pass through an 80-mesh sieve, add ethyl cellulose ethanol solution (1%) and polyvinylpyrrolidone ethanol solution (1%) in an appropriate amount to prepare granules, dried at 55°C for 1.5 hours, passed through a 20-mesh sieve for sizing, then added a lubricant, packed into capsules, and obtained the compound capsule of the present invention.

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Abstract

The invention relates to a traditional Chinese medicine composition and a preparation used for treating diabetic nephropathy, and a preparation method thereof. The medical composition is prepared from coptis chinensis, common anemarrhena, radix astragali mongolici, epimeddium, motherwort, leech, and salvia miltiorrhiza. The preparation is prepared through a common traditional Chinese medicine preparation method. The preparation has substantial treatment effect upon diabetic nephropathy, low toxic and side effect, and stable curative effect. Also, the method has advantages of simple operation,low cost, and controllable quality. The preparation and the preparation method are suitable to be applied in industrialized productions.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a composition for treating diabetic nephropathy containing traditional Chinese medicines such as coptis and epimedium, a preparation thereof and a preparation method thereof. Background technique [0002] Diabetic Nephropathy (Diabetic Nephropathy DN), also known as diabetic glomerulosclerosis, is a common complication of diabetes and one of the manifestations of systemic microangiopathy in diabetes. The clinical features are proteinuria, progressive renal impairment, hypertension, and edema. , Severe renal failure in the late stage is one of the main causes of death in diabetic patients. In recent years, with the prolongation of the average life expectancy of the Chinese population, changes in living and eating habits, and structural changes, the prevalence of diabetes has shown a linear upward trend, and due to the improvement of treatment methods, the s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8964A61K9/48A61K9/20A61K9/16A61P3/10A61P13/12A61K35/62
Inventor 张铁军朱雪瑜龚苏晓田成旺廖茂梁
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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