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Amoxicillin and probenecid compound suspension injection for livestock and preparation method thereof

A technology for suspension injection and probenecid compound, which is applied in the directions of liquid delivery, emulsion delivery, peptide/protein components, etc., can solve the problems of labor-intensive, time-consuming, increased bacterial resistance, short biological half-life, etc. The effect of reducing the number of administrations, easy industrial production, and simple preparation process

Active Publication Date: 2013-05-01
武汉回盛生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the common injections currently used clinically in the field of veterinary medicine have the following disadvantages: ①The biological half-life is short, and clinical application needs to be administered at least twice a day, which is difficult to implement. Frequent administration not only consumes manpower and time, but also causes stress in animals. ②Plasma drug concentration curve is generally wavy, showing obvious peaks and troughs, which increases the risk of toxic and side effects in animals; ③Continuous administration will inevitably lead to the increase of bacterial drug resistance, further aggravating the difficulty of treatment

Method used

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  • Amoxicillin and probenecid compound suspension injection for livestock and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A compound suspension injection of amoxicillin and probenecid for veterinary use, each 1L of the injection is composed of the following components: 150g of amoxicillin, 15g of probenecid, 10g of aluminum monostearate, analgesic lidocaine hydrochloride Ingredient 1.5g, preservative chlorobutanol 0.15g, antioxidant tert-butyl-p-hydroxyanisole 0.6g and the rest rapeseed oil.

[0024] The preparation method of above-mentioned amoxicillin and probenecid compound suspension injection for veterinary use, the steps are as follows:

[0025] (1) Preparation of oily colloid: take 400ml of rapeseed oil and heat it to 110°C, add 10g of aluminum monostearate into it, stir and dissolve to form an oily colloid;

[0026] (2) Dispersing drugs: Add 150g of amoxicillin and 15g of probenecid to the above-mentioned oily colloid in turn, stir to make it evenly mixed, and then put the well-mixed oily colloid through a shear emulsifying mixer at 6000 rpm, disperse 20min;

[0027] (3) Grinding...

Embodiment 2

[0030] A compound suspension injection of amoxicillin and probenecid for veterinary use, each 1L of the injection is composed of the following components: 150g of amoxicillin, 45g of probenecid, 15g of aluminum monostearate, analgesic lidocaine hydrochloride Because of 2.5g, preservative chlorobutanol 0.45g, antioxidant tert-butyl p-hydroxyanisole 0.6g and the rest of the sesame oil.

[0031] The preparation method of above-mentioned amoxicillin and probenecid compound suspension injection for veterinary use, the steps are as follows:

[0032] (1) Preparation of oily colloid: take 400ml of sesame oil and heat it to 112°C, add 15g of aluminum monostearate to it, stir and dissolve to form an oily colloid;

[0033] (2) Dispersing drugs: Add 150g of amoxicillin and 45g of probenecid to the above-mentioned oily colloid in turn, stir to make it evenly mixed, and then put the well-mixed oily colloid through a shear emulsifying mixer at 5000 rpm, disperse 25min;

[0034] (3) Grindin...

Embodiment 3

[0037] A compound suspension injection of amoxicillin and probenecid for veterinary use, each 1L of the injection is composed of the following components: 150g of amoxicillin, 40g of probenecid, 20g of aluminum monostearate, analgesic lidocaine hydrochloride Yin 3g, preservative chlorobutanol 0.4g, antioxidant tert-butyl-p-hydroxyanisole 0.6g and castor oil of the remainder.

[0038] The preparation method of above-mentioned amoxicillin and probenecid compound suspension injection for veterinary use, the steps are as follows:

[0039] (1) Preparation of oily colloid: take 400ml of castor oil and heat it to 115°C, add 20g of aluminum monostearate into it, stir and dissolve into oily colloid;

[0040] (2) Dispersing drugs: Add 150g of amoxicillin and 40g of probenecid to the above-mentioned oily colloid in turn, stir to make it evenly mixed, then put the well-mixed oily colloid through a shear emulsifying mixer at 5000 rpm, and disperse 30min;

[0041] (3) Grinding the drug: d...

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Abstract

The invention belongs to the technical field of veterinary drug, and specifically discloses an amoxicillin and probenecid compound suspension injection for livestock and a preparation method thereof. The injection of the invention employs amoxicillin and probenecid as raw materials; the drugs are added into an oily dispersed phase containing colloid and grinded by a colloid mill to have a particle size reaching injection requirements. After an injection, the prepared injection can slowly and continuously release to play the role of slow release. The product of the present invention can substantially reduce drug administration frequencies, increase animal compliance and reduce animal stress reaction; a blood peak and valley phenomenon can be reduced to enhance drug effects and security; and the total dosage of drug id reduced, so that a minimum dosage can reach a maximum treatment effect.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a compound suspension injection of amoxicillin and probenecid for veterinary use and a preparation method thereof. Background technique [0002] Amoxicillin, also known as amoxicillin or amoxycillin, is the most commonly used penicillin-like broad-spectrum β-lactam antibiotic, which has a strong bactericidal effect and a strong ability to penetrate cell walls. It is one of the most widely used penicillins at present, and the preparations that have been developed in the field of veterinary medicine include injections and powders. Due to the characteristics of rapid onset and complete absorption of injections, the development of injection forms is currently the focus. [0003] Most of the common injections currently used clinically in the field of veterinary medicine have the following disadvantages: ①The biological half-life is short, and clinical application needs to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/43A61K31/195A61K9/10A61P31/04
Inventor 张卫元崔海港刘国庆陈翠兰张永丹肖飞李荣
Owner 武汉回盛生物科技股份有限公司
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