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Polymer nano hydrogel and preparation method thereof

A nano-hydrogel, polymer technology, applied in the field of hydrogel, can solve problems such as limitations, and achieve the effects of good stability, good degradability, and good biocompatibility

Active Publication Date: 2011-05-18
CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the Chinese patent document with the application number 200610148155.5 discloses a temperature-sensitive chemically cross-linked hydrogel, which is an amphiphilic block composed of polyethylene glycol as a hydrophilic block and degradable polyester as a hydrophobic block. Copolymer is the main body, and the polymer chemically cross-linked hydrogel formed by connecting cross-linkable groups, the hydrogel is only sensitive to temperature, not sensitive to pH value, ionic strength, oxidizing agent and reducing agent, and its application is limited

Method used

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  • Polymer nano hydrogel and preparation method thereof
  • Polymer nano hydrogel and preparation method thereof
  • Polymer nano hydrogel and preparation method thereof

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preparation example Construction

[0046] The present invention also provides a method for preparing the polymer nanohydrogel described in the above technical solution, comprising:

[0047] a) Mix the hydrophilic polymer, triethylamine and chloryl chloride, stir and react to obtain the first intermediate product, the hydrophilic polymer is polyethylene glycol or polyethylene glycol monomethyl ether, and the chloroyl chloride has the formula (IV) Structure:

[0048]

[0049] Among them, 1≤t≤65;

[0050] b) dissolving the first intermediate product and poly(L-glutamate)-b-poly(γ-2-chloroethyl-L-glutamate) in an organic solvent, adding sodium perselenide Aqueous solution, under anaerobic conditions for cross-linking reaction, after dialysis to obtain polymer nano hydrogel.

[0051] The present invention first uses hydrophilic polymer, triethylamine and chloryl chloride as raw materials to prepare terminal chlorine-functionalized hydrophilic compounds, that is, the first intermediate product, and then uses sod...

Embodiment 1～5

[0091] The preparation of the polyethylene glycol monomethyl ether of embodiment 1~5 end group chlorine functionalization

[0092] According to the consumption of each raw material in Table 1, prepare the polyethylene glycol monomethyl ether of terminal chlorine functionalization according to the following method:

[0093] Add 10g of polyethylene glycol monomethyl ether and 100mL of toluene to the reaction bottle, after azeotropic dehydration, dissolve the obtained product in 100mL of anhydrous dichloromethane, add triethylamine after cooling to 0°C, and then dropwise add chlorine Propionyl chloride, react at 0°C for 2 hours, then heat up to 25°C, and continue to react for 24 hours under stirring with a stirrer. After the reaction is completed, filter the reaction mixture, and after the filtrate is obtained, it is settled with ether, filtered, washed, and vacuum-dried at 25°C for 24 hours to obtain Polyethylene glycol monomethyl ether chloropropionate. Carry out nuclear magne...

Embodiment 6

[0098] The preparation of embodiment 6 polyethylene glycol monomethyl ether chloroacetate

[0099] Add 10g of polyethylene glycol monomethyl ether with a number average molecular weight of 5000 and 100mL of toluene to the reaction flask, and after azeotropic dehydration, dissolve the obtained product in 100mL of anhydrous dichloromethane, cool to 0°C and add 1.01g Triethylamine, then add 4.52g of chloroacetyl chloride dropwise, react at 0°C for 2h, then raise the temperature to 25°C, continue to react for 24h under the stirring of the stirring bar, after the reaction is completed, filter the reaction mixture, and after the filtrate is obtained, settling and filtering with diethyl ether , washing, and vacuum drying at 25° C. for 24 hours to obtain polyethylene glycol monomethyl ether chloroacetate, the number average molecular weight of the polyethylene glycol monomethyl ether chloroacetate is 5076, and the reaction yield is 92.1%.

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Abstract

The invention provides a polymer nano hydrogel. The polymer substrate of the polymer nano hydrogel comprises a hydrophilic chain section and a segmented copolymer. The hydrophilic chain section is connected with the segmented copolymer through selenous bounds, the segmented copolymer is subjected to intermolecular crosslink through selenous bounds, the hydrophilic chain section has a structure shown in the formula (I) or the formula (II), and the segmented copolymer has a structure shown in the formula (III). The invention further provides a preparation method of the polymer nano hydrogel, which comprises the following steps of: a) mixing hydrophilic polymer, triethylamine and chloroacetyl chloride, and stirring and reacting to obtain a first intermediate, wherein the hydrophilic polymer is polyethylene glycol or polyethylene glycol monomethyl ether, and the chloroacetyl chloride has a structure shown in the formula (IV); b) dissolving the first intermediate product and poly(L-glutamic acid)-b-poly(gamma-2-chloroethyl-L-glutamic acid) in an organic solvent, adding a sodium selenite water solution, performing crosslink reaction under anaerobic conditions, and dialyzing to obtain the polymer nano hydrogel.

Description

technical field [0001] The invention relates to the field of hydrogel technology, in particular to a polymer nano hydrogel and a preparation method thereof. Background technique [0002] Sustained drug release is the combination of drugs and drug carriers, through diffusion, penetration, etc. in the body, so that the drug can be continuously released at an appropriate concentration, so as to fully exert the efficacy of the drug. Polymers such as polyesters and polyamino acids have become the main materials for drug carriers due to their advantages of non-toxicity, good biocompatibility, and biodegradability. [0003] Polymers usually act as drug carriers in the form of solid polymers, polymer nanomicelles or polymer nanohydrogels. Among them, solid polymers need to be implanted into the human body, which will cause surgical trauma; polymer nanomicelles are nano-sized core-shells formed by self-assembly of amphiphilic block copolymers with hydrophilic blocks and hydrophobic ...

Claims

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Application Information

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IPC IPC(8): C08L71/08C08L77/04C08K3/30C08J3/24C08J3/075C08G65/48C08G69/48A61K47/34A61K47/10
Inventor 庄秀丽丁建勋汤朝晖陈学思
Owner CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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