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Hollow core-shell nanometer mesoporous medicament carrying system with magnetism and luminescent performance, preparation method and application thereof

A technology with luminescent properties and magnetic properties, which can be used in medical preparations of non-active ingredients, preparations for in vivo experiments, drug delivery, etc. It can solve the problems of disintegration and release, poor thermal stability and chemical stability, and achieve easy operation , good water solubility and good biocompatibility

Active Publication Date: 2011-02-09
中国科学院上海硅酸盐研究所苏州研究院
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the inherent characteristics of organic materials, it was found during the research that these organic carrier systems inevitably have poor thermal and chemical stability in the environment of organisms, and are easily swallowed by the immune system and disintegrated. And other issues

Method used

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  • Hollow core-shell nanometer mesoporous medicament carrying system with magnetism and luminescent performance, preparation method and application thereof
  • Hollow core-shell nanometer mesoporous medicament carrying system with magnetism and luminescent performance, preparation method and application thereof
  • Hollow core-shell nanometer mesoporous medicament carrying system with magnetism and luminescent performance, preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0038] Embodiment 1: Preparation of β-FeOOH nanoparticles

[0039] Using hydrothermal method, 4mmol FeCl 3 ·6H 2 O and 1.0 g of polyvinylpyrrolidone (PVP, K-30) were dissolved in 70 mL of deionized water, transferred to a 100 mL stainless steel hydrothermal kettle with a polytetrafluoroethylene liner, and placed in an oven at 100 °C for 10 h. Take it out, cool to room temperature, centrifuge, wash with water three times, and vacuum dry at room temperature for 36 hours to obtain spindle-shaped β-FeOOH nanoparticles.

[0040] The TEM picture of embodiment 1 gained material is as figure 1 As shown, it can be seen from the figure that the average length of nanoparticles is 180nm; the average diameter is 53nm; figure 1 The illustration in (b) is figure 1 Selected-area electron diffraction pattern of a β-FeOOH nanoparticle in (b), showing that the nanoparticle has a single-crystal structure. XRD spectrum as image 3 As shown in (a), it shows that the β-FeOOH nanoparticles obta...

Embodiment 2

[0041] Example 2: The surface of β-FeOOH is coated with SiO containing alkyl chains 2 Preparation of Nanocomposite Core-Shell Materials

[0042] Using the sol-gel method, uniformly disperse 100 mg of β-FeOOH nanoparticles obtained in Example 1 in a mixed solution of 50 mL of water and 250 mL of isopropanol, add 7.5 mL of ammonia water, and then add dropwise a total volume of 0.4 mL of orthosilicon Tetraethyl orthosilicate and octadecyltrimethoxysilane, continue to stir for 3h after adding, then centrifuge, wash the solid with ethanol 3 times, and finally vacuum dry at room temperature for 24h; Tetraethyl orthosilicate and octadecyl The amount of substance ratio of trimethoxysilane was 4.7.

[0043] The TEM picture of embodiment 2 gained material is as figure 2 As shown in (a), it shows that the surface of β-FeOOH obtained in Example 2 wraps SiO containing alkyl chains 2 The composite core-shell nanoparticles have a core-shell structure, and the average thickness of the she...

Embodiment 3

[0044] Example 3: α-Fe 2 o 3 @mSiO 2 Preparation of Hollow Nanocomposite Capsules

[0045] The β-FeOOH surface of the obtained β-FeOOH of Example 2 is wrapped with SiO containing alkyl chains 2 The composite core-shell nanoparticles were heat-treated in air at 550 °C for 6 hours to remove the pore-forming agent and transform the inner core from β-FeOOH to α-Fe 2 o 3 , so that a cavity is formed in the inner core to form a hollow nanocapsule structure; the heating rate of the heat treatment is 1° C. / min.

[0046] The TEM picture of embodiment 3 gained material is as figure 2 Shown in (b), show that embodiment 3 gained α-Fe 2 o 3 @mSiO 2 The nanocomposite capsule has a cavity structure, and the inner α-Fe 2 o 3 It has a hollow nanocapsule structure, the outer wall of which is tightly attached to the inner wall of mesoporous silica. XRD spectrum as image 3 Shown in (c), show that embodiment 3 gained α-Fe 2 o 3 @mSiO 2 The structure of β-FeOOH no longer exists in ...

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Abstract

The invention discloses a hollow core-shell nanometer mesoporous medicament carrying system with magnetism and luminescent performance. In the medicament carrying system, a magnetic Fe3O4 hollow capsule is used as an inner core, mesoporous SiO2 is used as a shell layer, and an organic luminescent material and a biocompatible polymer are modified on the outer surface of the shell layer. A preparation method of the medicament carrying system comprises the following steps of: firstly, preparing monodisperse fusiform beta-FeOOH nanoparticles by a hydro-thermal method, coating mesoporous silicon dioxide on the surfaces of the nanoparticles, removing a pore-forming agent through thermal treatment, and simultaneously, converting the inner core into alpha-Fe2O3 from the beta-FeOOH, so that a cavity is generated in the inner core so as to form a hollow nanometer capsule structure; secondly, converting the inner core into the magnetic Fe3O4 hollow capsule through reduction treatment; and finally, modifying the organic luminescent material and the biocompatible polymer on the surface of the magnetic mesoporous nanometer capsule. The nanometer composite capsule of the invention has the advantages of core-shell structure and cavity structure, uniform particle size, high biocompatibility and excellent magnetism.

Description

technical field [0001] The invention relates to a nano imaging material and a nano medicine-carrying material, in particular to a hollow core-shell nano mesoporous drug-carrying system with a cavity structure in a magnetic inner core, which has magnetic and luminous properties, and its preparation and application. Background technique [0002] Malignant tumor is the number one "killer" that endangers human existence. The development of new technologies for early diagnosis of malignant tumors and the search for safe and effective antineoplastic drugs with high tumor targeting have become clinical problems to be solved urgently. [0003] Magnetic resonance imaging (MRI) technology is one of the most effective clinical diagnostic methods for rapid detection of early tissue cancer. Usually, in order to enhance the contrast between MRI images of cancerous tissue and normal tissue, it is necessary to select a suitable contrast enhancer to reveal anatomical features. Among the co...

Claims

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Application Information

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IPC IPC(8): A61K49/18A61K47/34A61K47/22A61K47/04A61K49/08A61K49/10A61K49/12A61K47/02A61K47/10
Inventor 吴惠霞施剑林
Owner 中国科学院上海硅酸盐研究所苏州研究院
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