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Capsule containing cefixime liposome and preparation method thereof

A technology of cefixime and liposome, which is applied in the field of medicine, can solve the problems of poor solubility, stability and bioavailability, and achieve the effects of improving bioavailability, low leakage rate, and significant improvement

Inactive Publication Date: 2011-02-09
王丽燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Chinese patents CN101606913A and CN101401810A disclose cefixime dispersible tablets and their preparation methods. The dispersible tablets are all made from cefixime raw materials without any modification. The solubility, stability and biological Utilization is poor

Method used

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  • Capsule containing cefixime liposome and preparation method thereof
  • Capsule containing cefixime liposome and preparation method thereof
  • Capsule containing cefixime liposome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Embodiment 1: the preparation of cefixime liposome

[0073] Name of raw material

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

Cefixime

50.00

100.00

200.00

Hydrogenated Soy Lecithin

200.00

400.00

800.00

Hydrogenated egg yolk lecithin

200.00

400.00

800.00

cholesterol

400.00

800.00

1600.00

Polysorbate 80

77.00

154.00

308.00

total

927.00

1854.00

3708.00

[0074] Preparation:

[0075] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and polysorbate 80 in an appropriate amount of dehydrated alcohol according to the prescription amount, and mix uniformly to obtain solution I; 32 times;

[0076] (B) taking by weighing the cefixime of prescription quantity, adding the phosphate buffer saline solution that the appropriate pH value is 7.8 makes it dissolve completely, obtains cefixime solution...

Embodiment 2

[0083] Embodiment 2: the preparation of cefixime liposome

[0084] Name of raw material

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

Cefixime

50.00

50.00

100.00

Hydrogenated Soy Lecithin

162.50

325.00

650.00

Hydrogenated egg yolk lecithin

162.50

325.00

650.00

cholesterol

325.00

650.00

1300.00

Polysorbate 80

62.50

125.00

250.00

total

762.50

1525.00

3050.00

[0085] Preparation:

[0086] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and polysorbate 80 in an appropriate amount of dehydrated alcohol according to the prescription amount, and mix uniformly to obtain solution I; 28 times;

[0087] (B) take by weighing the cefixime of recipe quantity, add the phosphate buffer saline solution that proper pH value is 7.6 and make it dissolve completely, obtain cefixime solution;

[0088] (C) take ...

Embodiment 3

[0094] Embodiment 3: the preparation of cefixime liposome

[0095] Name of raw material

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

[0096] Cefixime

50.00

100.00

200.00

Hydrogenated Soy Lecithin

130.00

260.00

520.00

Hydrogenated egg yolk lecithin

130.00

260.00

520.00

cholesterol

260.00

520.00

1040.00

Polysorbate 80

50.00

100.00

200.00

total

620.00

1040.00

2080.00

[0097] Preparation:

[0098] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and polysorbate 80 in an appropriate amount of dehydrated alcohol according to the prescription amount, and mix uniformly to obtain solution I; 32 times;

[0099] (B) take by weighing the cefixime of recipe quantity, add the phosphate buffer saline solution that an appropriate pH value is 7.0 and make it dissolve completely, obtain cefixime...

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PUM

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Abstract

The invention relates to a cefixime liposome and a preparation method thereof as well as a capsule containing the cefixime liposome. The capsule comprises the cefixime liposome and a pharmaceutically acceptable vector, wherein the cefixime liposome is prepared from the following components in parts by weight: 1 part of cefixime, 1.25-5 parts of hydrogenated soybean lecithin, 1.25-5 parts of hydrogenated egg yolk lecithin, 1.25-10 parts of cholesterol and 0.1-2.5 parts of polysorbate 80. The capsule not only accords with the requirement on Chinese pharmacopoeia, but also has the advantages of stabler storage and rapider drug effect exertion and remarkably improved bioavailability compared with the common pharmaceutical cefixime pharmaceutical composition at a room temperature.

Description

technical field [0001] The invention relates to a cefixime liposome, a preparation method thereof and a capsule containing the cefixime capsule. The cefixime capsule has a higher dissolution rate than a common cefixime pharmaceutical composition, a faster drug effect, and a biological The advantage of significantly improved utilization belongs to the technical field of medicine. Background technique [0002] Acute pelvic inflammatory disease refers to the acute inflammation of female pelvic reproductive organs and its surrounding connective tissue and pelvic peritoneum, including metritis, salpingo-oophoritis, pelvic connective tissue inflammation and pelvic peritonitis, which can occur in one or several places at the same time. One of the common diseases. The development of acute pelvic inflammatory disease can cause diffuse peritonitis, sepsis, septic shock, and severe cases can be life-threatening. Lower abdominal pain accompanied by fever at the time of onset. If the c...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61P15/00A61K31/546A61P31/04A61K47/28
Inventor 王丽燕
Owner 王丽燕
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