Application of ricinus agglutinin 120 to the resistance against influenza A virus

Abstract

The invention relates to application of ricinus agglutinin 120 (RCA120) to the resistance against influenza A virus. Ricinus agglutinin 120 can be combined with sugar chain structures on HA (Hemagglutinin) and NA (Neuraminidase) on the surface of the influenza A virus, and can act on the influenza virus HA to take effect in the early stage of the infection of host cells by the virus. The virus cannot be absorbed on the surface of the host cells through influencing the combination of HA and sialoglycopeptide chain receptors on the cell membrane of the host cells, and therefore, the virus cannot infect the host cells. The ricinus agglutinin 120 can act on the influenza virus NA to inhibit the activity of neuraminidase, prevent the mature progeny viruses from going away from the host cells, and prevent the release and the diffusion of the mature progeny viruses.

Description

technical field [0001] The present invention relates to the application of ricin bean lectin in inhibiting viruses, in particular to the application of ricin bean lectin 120 in inhibiting reproduction and spread of influenza A virus. Background technique [0002] 1. Introduction to Influenza A Virus [0003] Influenza, referred to as influenza, is an acute respiratory infectious disease caused by influenza virus. The clinical manifestations are acute onset, high fever, myalgia, headache accompanied by severe discomfort, dry cough, sore throat or rhinitis. Recovery within one to two weeks. But influenza is different from common colds. The terrible thing about influenza virus is that it infects quickly, spreads widely, and causes complications that can lead to death in the weak. Influenza has a short incubation period, spreads rapidly through respiratory droplets, and easily mutates antigens. The population is generally susceptible to mutated strains, and it is difficult to ...

AI Technical Summary

Problems solved by technology

However, after nearly two decades of research, ricin has not been effectively used in the diagnosis and treatment of clinical diseases. In summary, the following reasons have affected the practical application value of ricin: (1) Hemagglutinin has good specificity to RCA receptors, but the existence range and types of RCA receptors are too large, so that the specificity of RCA to specific cells is relatively low, and it is not convenient to bind to receptors to Identify specific types of cells; (2) The in vivo toxicity control of ricin has yet to be further studied. Although RCA can accurately bind to RCA receptors in vivo by coupling supports or drugs, RCA itself has a strong Physiological toxicity, may cause potential harm to human body

RCA is different from viruses and monoclonal antibodies, and its mechanism of action in vivo, degradation pathway and self-toxicity control methods are still unclear

[0007] 3. Introduction to Traditional Medicine

Due to the poor bioavailability of the drug, "Relenza" is used as an inhalation spray and sprayed on the patient's mouth or mucous membrane, and absorbed into the body through the mucous membrane to inhibit the virus. And it is not suitable for some people with pulmonary dysfunction, so the drug popularity rate is not as good as Tamiflu in oral form