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Method for preparing novel cefixime tablets and cefixime capsules

A technology of cefixime and capsules, which is applied in the field of pharmaceutical preparations, can solve the problems of cumbersome granulation process, small amount of excipients, and unsatisfactory dissolution rate of tablets, etc., achieve rapid blood drug concentration, increase dissolution rate, and avoid related substances Elevated effect

Active Publication Date: 2010-11-24
JIANGSU YABANG QIANGSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dissolution rate of the tablets prepared by this method is not ideal, and the amount of excipients is small, and the separate granulation process is more cumbersome

Method used

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  • Method for preparing novel cefixime tablets and cefixime capsules
  • Method for preparing novel cefixime tablets and cefixime capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: the preparation of cefixime capsule

[0017] Preparation prescription of the present invention is made up of following components by weight:

[0018] Cefixime 50g

[0019] Sodium Lauryl Sulfate 4g

[0020] Lactose 60g

[0021] Microcrystalline Cellulose 30g

[0022] Croscarmellose Sodium 15g

[0023] Magnesium Stearate 1g

[0024]

[0025] Make 1000 capsules

[0026] Preparation process: Weigh cefixime, sodium lauryl sulfate and lactose according to the above prescription, and carry out jet milling. Weigh microcrystalline cellulose and croscarmellose sodium according to the prescription amount, crush them and pass through an 80-mesh sieve, mix them evenly with the above air-pulverized materials, granulate them in a dry granulator, add magnesium stearate and mix them evenly before filling capsule.

Embodiment 2

[0027] Embodiment 2: the preparation of cefixime capsule

[0028] Preparation prescription of the present invention is made up of following components by weight:

[0029] Cefixime 100g

[0030] Sodium Lauryl Sulfate 4g

[0031] Lactose 30g

[0032] 20g pregelatinized starch

[0033] Croscarmellose Sodium 15g

[0034] Magnesium Stearate 1g

[0035]

[0036] Make 1000 capsules

[0037] Preparation Process:

[0038] Weigh cefixime, sodium lauryl sulfate and lactose respectively according to the above prescription, and carry out jet milling. Weigh pregelatinized starch and croscarmellose sodium according to the prescription amount, crush them and pass through an 80-mesh sieve, mix them evenly with the above-mentioned air-pulverized materials, granulate them in a dry granulator, add magnesium stearate and mix them evenly before filling capsule.

Embodiment 3

[0039] Embodiment 3: the preparation of cefixime tablet

[0040] Preparation prescription of the present invention is made up of following components by weight:

[0041] Cefixime 50g

[0042] Sodium Lauryl Sulfate 4g

[0043] Lactose 60g

[0044] Microcrystalline Cellulose 30g

[0045] Croscarmellose Sodium 20g

[0046] Magnesium Stearate 1g

[0047]

[0048] Made into 1000 pieces

[0049] Preparation Process:

[0050] Weigh cefixime, sodium lauryl sulfate and lactose respectively according to the above prescription, and carry out jet milling. Weigh microcrystalline cellulose and croscarmellose sodium according to the prescription amount, pass through an 80-mesh sieve after crushing, mix evenly with the above-mentioned air-pulverized material, granulate with a dry granulator, add magnesium stearate and mix evenly, and press piece.

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Abstract

The invention provides a method for preparing novel cefixime tablets and cefixime capsules. In the method, cefixime, a solubilizer and water soluble auxiliary materials are micronized and then mixed with other auxiliary materials, and the obtained products are granulated by a dry method, so that the stability of cefixime tablets and cefixime capsules is improved, and the dissolution rate of cefixime is also raised. The cefixime can be quickly absorbed by a patient after the patient takes the cefixime tablets and cefixime capsules, the plasma peak time is shortened and the plasma concentration can be quickly stabilized at a higher level, so that the treating effect is improved.

Description

technical field [0001] The invention relates to a new preparation method of cefixime tablets and capsules, belonging to the field of pharmaceutical preparations. Background technique [0002] Cefixime (cefixime) is an oral third-generation cephalosporin antibiotic, developed by Japan Fujisawa Co., Ltd., and first listed in Japan in 1987 by Japan Fujisawa Pharmaceutical Co., Ltd., with a trade name of Cefspan. Cefixime has the following characteristics: broad antibacterial spectrum, it has spectrum antibacterial effect on Gram-positive bacteria and negative bacteria; long half-life, can be taken only once or twice a day, easy to use; less cross-resistance It is extremely stable to the β-lactamase produced by various bacteria, and can effectively inhibit or kill Serratia, Enterobacter, Proteus, etc. that are clinically resistant to other cephalosporin antibiotics; the dose is small, and the body is widely distributed. High curative effect, low cost of use, strong market compe...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/48A61K31/546A61P31/04
Inventor 谢瑞丽陈再新葛育红赵晓红毛白杨盖海涛
Owner JIANGSU YABANG QIANGSHENG PHARMA
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