Asia1 type multi-epitope recombinant vaccine of bovine foot-and-mouth disease viruses and preparation method thereof
A foot-and-mouth disease virus and recombinant vaccine technology, applied in animal recombinant vaccines, bovine foot-and-mouth disease virus Asia1 type multi-epitope recombinant vaccine and its preparation field, can solve the problems of unsatisfactory animal immune effect, short duration, high cost, etc., to achieve guaranteed Serum high-titer antibody level, promotion of presentation ability and level, and effect of increasing immunogenicity
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[0024] The preparation of embodiment 1 bovine foot-and-mouth disease virus Asia1 type multi-epitope recombinant vaccine
[0025](1) Design and synthesis of multi-epitope genes for foot-and-mouth disease: The whole genome sequence of Asia1 type foot-and-mouth disease virus JS / 05 strain (GenBank accession number: EF149009.1) was selected for multi-epitope design, that is, the main structural protein gene VP1 was selected. Two immunogenic B cell epitopes (136-160aa, 198-211aa) are properly connected in series (ie: 136-160aa-linker-198-211aa), in order to prevent adjacent epitopes from connecting to each other to form new epitopes, in A linker-GGSSGG is added between adjacent epitopes to minimize the impact between adjacent epitopes to ensure the integrity of the structure and function of the epitopes. To increase the potency of the epitope, the concatemer of the two epitopes was repeated once, ie: 136-160aa-linker-198-211aa-linker-136-160aa-linker-198-211aa. In order to insert t...
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