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Preparation method for calcium polyphosphate-tricalcium phosphate bone bracket

A technology of tricalcium phosphate bone and calcium polyphosphate, applied in medical science, prosthesis and other directions, can solve the problems of high porosity of porous ceramics, poor control of pore shape, poor mechanical strength of porous bodies, etc., to achieve high efficiency and cost. low cost effect

Inactive Publication Date: 2012-09-12
SHANGHAI NAT ENG RES CENT FORNANOTECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] After searching the prior art documents, it was found that Chinese Patent Document No. CN1736955 records a kind of porous ceramics prepared by combining slurry foaming and starch in-situ solidification molding process. The porous ceramics prepared by this technology have high porosity and contain two different pore size, but this method has poor control over the pore shape, and the mechanical strength of the obtained porous body is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Weigh 0.1g of PVA, put it into a 50ml beaker, place it in an oven at 110°C, take it out after 60 minutes, cool it to room temperature, filter it with gauze, and set it aside.

[0026] 2. Weighing 8 grams of TCP / CPP composite ceramic powder with a mass ratio of 20.0, 0.45 grams of methylcellulose powder, mechanically mixing; adding 15 milliliters of the above-mentioned PVA solution, 3% H 2 o 2 2 ml, mixed by ball milling, the ball milling speed is 300 rpm, and the ball milling time is 4 hours.

[0027] 3. The resulting slurry was poured into a plastic mold and dried by a four-step drying method, namely drying at 28°C for 1 day, drying at 35°C for 1 day, drying at 45°C for 1 day, and drying at 60°C for 1 day.

[0028] 4. The porous green body is placed in a crucible after demoulding, and placed in a programmed temperature-controlled high-temperature sintering furnace for sintering. The heating program is 0-300°C for 3 hours, 300-600°C for 1 hour, and the heating rate ...

Embodiment 2

[0030] 1. Weigh 0.1g of PVA, put it into a 50ml beaker, place it in an oven at 110°C, take it out after 60 minutes, cool it to room temperature, filter it with gauze, and set it aside.

[0031] 2. Weighing 8 grams of TCP / CPP composite ceramic powder with a mass ratio of 15.0, 0.6 grams of methylcellulose powder, mechanically mixing; adding 10 milliliters of the above-mentioned PVA solution, 3% H 2 o 2 5 milliliters, 2 milliliters of deionized water, mixed by ball milling, ball milling speed 350 rpm, ball milling time 6 hours.

[0032]3. The resulting slurry was poured into a plastic mold and dried by a four-step drying method, namely drying at 28°C for 1 day, drying at 35°C for 1 day, drying at 45°C for 1 day, and drying at 60°C for 1 day.

[0033] 4. After demoulding, the porous green body is placed in a crucible and sintered in a programmed temperature-controlled high-temperature sintering furnace. The heating program: 0-300°C for 3 hours, 300-600°C for 1 hour, and the heat...

Embodiment 3

[0035] 1. Weigh 0.1g of PVA, put it into a 50ml beaker, place it in an oven at 110°C, take it out after 60 minutes, cool it to room temperature, filter it with gauze, and set it aside.

[0036] 2. Weighing 8 grams of TCP / CPP composite ceramic powder with a mass ratio of 25.0, 0.75 grams of methylcellulose powder, mechanically mixing; adding 3 milliliters of the above-mentioned PVA solution, 3% H 2 o 2 3 milliliters, 12 milliliters of deionized water, mixed by ball milling, ball milling speed 400 rpm, ball milling time 4 hours.

[0037] 3. The resulting slurry was poured into a plastic mold and dried by a four-step drying method, namely drying at 28°C for 1 day, drying at 35°C for 1 day, drying at 45°C for 1 day, and drying at 60°C for 1 day.

[0038] 4. The porous green body is placed in a crucible after demoulding, and sintered in a high-temperature sintering furnace with programmed temperature control. The heating program: 0-300°C for 3 hours, 300-600°C for 1 hour, and the ...

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Abstract

A preparation method for calcium polyphosphate-tricalcium phosphate bone bracket comprises the steps of proportionally ball-milling and mixing calcium phosphate ceramic powder, size stabilizer methylcellulose, surfactant polyvinyl alcohol, foaming agent hydrogen peroxide and de-ionized water in order to prepare compound ceramic slurry, pouring the slurry into a mould, drying in an oven with four-step drying method, and then sintering the dried green body under high temperature in order to acquire porous calcium phosphate ceramic bracket. The big aperture of a big pore of the acquired porous calcium phosphate ceramic bracket of the invention is 200 to 600 microns, the micro-pore aperture thereof is 2 to 5 microns, the whole porosity thereof is from 60 to 90 percent and the compressive strength thereof is 0.5 to 7.0 Mpa. Furthermore, the method has low cost and high efficiency and can be applied to large-scale production.

Description

technical field [0001] The invention relates to a method in the technical field of biomedical materials, in particular to a calcium polyphosphate-tricalcium phosphate bone scaffold with a porosity greater than 70% based on a composite slurry foaming method and a preparation method thereof. Background technique [0002] Studies in the past ten years have shown that tricalcium phosphate materials (β-TCP: calcium phosphate, Ca 3 (PO 4 ) 2 ) and calcium polyphosphate material (CPP: Calcium polyphosphate, (Ca(PO 3 ) 2 )n) not only inherits the excellent biocompatibility and mechanical strength of hydroxyapatite materials, but also has good biodegradability, osteoinductive properties and bone resorption properties. The degradation performance of β-TCP is 10 to 20 times that of hydroxyapatite; CPP is an inorganic single-chain polymer containing calcium, phosphorus and oxygen formed by P-O-P bonds in series, because P-O-P bonds are easy to absorb water and decompose in a humid a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/10A61L27/56
Inventor 陈高祥范纯泉叶晓健金彩虹何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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