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Broad-spectrum long-acting anti-pathogen antiviral disinfectant, preparation method and application thereof

A disinfectant and anti-bacteria technology, applied in the field of sanitation and disinfection, can solve the problems of inconvenient antibacterial disinfection, etc., and achieve the effect of long effective time, wide application range and easy availability of raw materials

Inactive Publication Date: 2010-06-02
WUHAN TIANYIJUWEI SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these special immobilization technologies are not convenient for antibacterial disinfection of large-area spaces

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: The prepared catalyst is uniformly mixed with solid hydrogen peroxide, citric acid, and water in a mass ratio of 1:50:50:20000, and the mixed solution is evenly spread on ordinary glass slides by spraying, and the large intestines are respectively Bacillus ATCC25922, Staphylococcus aureus ATCC6538 and Klebsiella pneumonia AS1.1736 three test bacteria were inoculated on the surface of ordinary glass slides that had been sprayed with disinfectant and without disinfectant (control sample). The initial bacterial count was about 10 5 cfu / piece, after 24 hours of light, the number of viable bacteria on the surface of the control glass is about 10 6 cfu / tablet, the number of viable bacteria in the test group is less than 20cfu / tablet, the antibacterial contribution value of this disinfectant R Light More than 99%, antibacterial rate R total Also greater than 99%.

Embodiment 2

[0021] Example 2: The prepared catalyst was uniformly mixed with solid hydrogen peroxide, malic acid, and water in a mass ratio of 1:50:50:20,000 to form a disinfectant solution. The gram-positive bacteria Staphylococcus aureus and Gram For the negative bacteria, E. coli ATCC 25922 was selected as the tested bacteria, and the hydrolyzed casein agar medium and Brucella broth were used as the medium, and the MIC concentration of the disinfectant was measured to be 625 mg / L. Prepare a series of parallel drug-containing plates with disinfectant concentrations of 625mg / L and 20000mg / L, each with a blank control without drugs in parallel, and set the light group (60W incandescent lamp, 50cm from the glass door incubator, 24 After hours, place it under natural conditions) and the light-proof group (to completely shield any light source), and place it at room temperature for 0 to 20 days under moisturizing conditions. Take out each petri dish, evenly spread the mixed bacterial liquid o...

Embodiment 3

[0022] Example 3: The prepared catalyst was uniformly mixed with solid hydrogen peroxide, malic acid, and water in a mass ratio of 1:50:50:10000 to form a disinfectant. The following experiments were used to study the disinfection of influenza virus (H3N2). Activity: Prepare a stock solution of disinfectant solution with an initial concentration of 10mg / mL with 1×PBS, add a certain amount of disinfectant and virus reaction solution to a petri dish with a diameter of 5.5 cm, the total volume of the reaction solution is 10mL, disinfectant The concentration is 2mg / mL, and the reaction is maintained under dark conditions and ultraviolet light irradiation (Philips 8W fluorescent ultraviolet lamp tube, dominant wavelength 365nm, directly above the liquid surface, and the distance from the liquid surface is 10cm). During the reaction, the solution was stirred with an electromagnetic stirrer. After different reaction times, the reaction solution was centrifuged, and the supernatant was...

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PUM

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Abstract

The invention provides a broad-spectrum long-acting anti-pathogen antiviral disinfectant, a preparation method and application thereof, which relates to disinfectants consisting of catalysts, inorganic enhancement promoters and balancing additives. Main composition of the disinfectant includes compound catalysts of inorganic oxides and inorganic salts, slow-release inorganic promoters and balancing organic additives. The disinfectant has the advantages of no harm to human bodies and environment, long effective acting time, wide application range, convenient implementation, readily available raw materials, simple preparation process, no harsh requirements for synthesis conditions, low cost, long-term effective killing function to various types of pathogenic microorganisms, suitability for disinfecting various object surfaces, no toxicity, good stability, wide pH range of application and strong capability of killing pathogenic microorganisms. The advantages ensure that the disinfectant can efficiently resist pathogenic microorganisms for a long term so as to effectively disinfect object surfaces.

Description

Technical field: [0001] The invention relates to the field of sanitation and disinfection, in particular to a disinfectant composed of a catalyst, an inorganic strengthening aid and a balance additive. Background technique: [0002] The growth of pathogenic microorganisms on the surfaces of appliances and living spaces in daily life and production can lead to the occurrence of different diseases. In particular, the occurrence of major infectious epidemics is one of the focal issues that endanger the healthy life and economic development of our people. One of the common and effective methods to solve this problem is to use chemical disinfection. Chemical disinfection can be used for preventive disinfection and terminal disinfection. Commonly used disinfectants include alkali disinfectants, chlorine disinfectants, strong oxidant disinfectants, iodine disinfectants, alcohol disinfectants, aldehyde disinfectants, surfactants, decamethyl bromide disinfectants, compound Phenolic disi...

Claims

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Application Information

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IPC IPC(8): A01N59/00A01N59/16A61K33/24A61K33/26A01P1/00A61P31/00
Inventor 唐蘅敏吴义国朱丽华
Owner WUHAN TIANYIJUWEI SCI & TECH
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