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Zinc gluconate pellets and preparation method thereof

The technology of zinc gluconate and pellets is applied in the directions of food preparation, pharmaceutical formulations, and medical preparations containing active ingredients, etc., and can solve the problems of granules easily absorbing moisture and dampness, irritating gastric mucosa, and low bioavailability, etc. To achieve the effect of small fluctuation of blood drug concentration, good efficacy and high bioavailability

Inactive Publication Date: 2010-05-12
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The products currently developed are basically ordinary tablets, capsules and granules, but the disintegration time of the above-mentioned tablets and capsules is long; they disintegrate at a certain point in the body, which is irritating to the gastric mucosa; the granules The agent is easy to absorb moisture and become damp, its properties are unstable, and its bioavailability is low.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Prepare pellet formulations as follows:

[0034] (1) Get the zinc gluconate of above-mentioned formula quantity and add starch, pulverize to micronized level with ball mill, mix;

[0035] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0036] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0039] Prepare pellet formulations as follows:

[0040] (1) Get the zinc gluconate of above-mentioned formula quantity and add starch, pulverize to micronized level with ball mill, mix;

[0041] (2) the adhesive polyvinylpyrrolidone is dissolved in water;

[0042] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0045] Prepare pellet formulations as follows:

[0046] (1) Get the zinc gluconate of above-mentioned formula amount and add dimension crystal cellulose, pulverize to micronization grade with ball mill, mix;

[0047] (2) hydroxypropyl methylcellulose is dissolved in an appropriate amount of 70% ethanol;

[0048] (3) The pellets are made by the centrifugal-fluidized pelletizing method.

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Abstract

The invention provides a zinc gluconate pellet preparation, which is prepared from zinc gluconate and pharmaceutic adjuvant, and is characterized in that: the pharmaceutic adjuvant is an excipient and an adhesive, wherein in the pellet preparation, the weight percent of the zinc gluconate is 10 to 80 percent, the weight percent of the excipient is 12 to 89 percent and the weight percent of the adhesive is 1 to 8 percent. The pellet preparation can be prepared into a slow release preparation or an enteric-coated preparation. The zinc gluconate pellet preparation has high dissolution rate, and high bioavailability; and the method is simple, convenient, and easy to operate.

Description

Technical field: [0001] The invention relates to a micropill of natural food extract and a preparation method thereof, in particular to a micropill made of zinc gluconate and a preparation method thereof. Background technique: [0002] Zinc is an indispensable substance for the growth and development of the human body and the maintenance of normal organ functions, and it can also inhibit the formation of cancer. Zinc deficiency can cause growth stagnation in children, decreased male sexual function, and deformed children in pregnant women. Zinc has the cytoprotective effect of prostaglandins, promotes mucus secretion, and promotes epithelial cell renewal, and zinc deficiency can hinder ulcer healing. About 40 kinds of diseases are related to zinc deficiency. Therefore, zinc deficiency has attracted more and more attention in recent years. [0003] Zinc gluconate dissociates into zinc ions and gluconic acid in the body, providing the human body with the extremely important ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/192A61P3/02A23L1/30
Inventor 李红艳
Owner JF PHARMALAND TECH DEV
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