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Paracetamol, pseudoephedrine and chlorphenamine compound sustained release preparation

A paracetamol, sustained-release preparation technology, applied in the field of medicine, to achieve the effect of less medication times, stable blood drug concentration, and high bioavailability

Inactive Publication Date: 2010-03-03
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since there is no specific treatment at all, it is not necessary for the virus to be firm, and only symptomatic treatment can be used to relieve many symptoms of the common cold

Method used

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  • Paracetamol, pseudoephedrine and chlorphenamine compound sustained release preparation
  • Paracetamol, pseudoephedrine and chlorphenamine compound sustained release preparation
  • Paracetamol, pseudoephedrine and chlorphenamine compound sustained release preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] prescription:

[0021] Acetaminophen 325g

[0022] Pseudoephedrine Hydrochloride 90g

[0023] Chlorpheniramine Maleate 4g

[0024] Hypromellose 40g

[0025] Carnauba Wax 15g

[0026] Microcrystalline Cellulose 36g

[0027] 10% Povidone K 30 Aqueous solution

[0028] Magnesium Stearate Appropriate amount

[0029] Opadry 15g

[0030] Appropriate amount of pure water

[0031]

[0032] Made into 1000 pieces (grains / bag)

[0033] Preparation method 1:

[0034] (1) Preparation of granules Carnauba wax, hydroxypropylmethyl cellulose, and microcrystalline cellulose were respectively passed through an 80-mesh sieve and mixed uniformly. Then add pseudoephedrine hydrochloride, chlorpheniramine maleate, and acetaminophen in turn, mix well, and add 10% povidone K 30 The aqueous solution is a soft material made of an adhesive, wet granules are prepared through a 20-mesh sieve, dried at 50°C, granulated through a 20-mesh sieve, a...

Embodiment 2

[0050] prescription:

[0051] Acetaminophen 325g

[0052] Pseudoephedrine Hydrochloride 90g

[0053] Chlorpheniramine Maleate 4g

[0054] Hypromellose K100M 30g

[0055] Hypromellose E5 75g

[0056] Microcrystalline Cellulose 45g

[0057] 10% Copovidone K 30 Aqueous solution

[0058] Appropriate amount of stearic acid

[0059] Opadry 50g

[0060] Appropriate amount to completely dissolve in water

[0061]

[0062] Made into 1000 pieces (grains / bag)

[0063] Preparation method 1:

[0064] (1) Preparation of granules: Hypromellose and microcrystalline cellulose are passed through 80-mesh sieves respectively, fully mixed with equal increment method, then add pseudoephedrine hydrochloride, acetaminophen, maleic acid chloride pheniramine 2g, make it mix well, take 10% copovidone K 30 The aqueous solution is a soft material made of adhesive, wet granules are prepared through a 20-mesh sieve, dried at 60°C, granulated through a 20-m...

Embodiment 3

[0082] prescription:

[0083] pseudoephedrine sulfate

90g

Chlorpheniramine maleate

2g

Acetaminophen

325g

sodium alginate

60g

gelatin

58g

pregelatinized starch

50g

10% Povidone K 25 aqueous solution

Appropriate amount

Magnesium stearate

Appropriate amount

[0084] Coating prescription:

[0085] pseudoephedrine sulfate

30g

Chlorpheniramine maleate

2g

Opadry

50g

[0086] ethanol

Appropriate amount until completely dissolved

[0087] Made into 1000 pieces (grains / bag)

[0088] Preparation:

[0089] (1) Preparation of granules Sodium alginate, gelatin, and pregelatinized starch were respectively passed through a 100-mesh sieve, fully mixed in an equal increment method, and then added pseudoephedrine sulfate, chlorpheniramine maleate, and para-acetamide Phenol, mixed well with 10% Povidone K 25 The aque...

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PUM

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Abstract

The invention relates to a sustained release preparation taking paracetamol and pseudoephedrine or physiologically acceptable salts thereof, and chlorphenamine or physiologically acceptable salts thereof as active components, and provides a compound preparation which can comprehensively overcome cold related symptoms and of which all the active components are slowly released.

Description

technical field [0001] The invention relates to a sustained-release preparation which takes acetaminophen, pseudoephedrine or a physiologically acceptable salt thereof and chlorpheniramine or a physiologically acceptable salt thereof as active components, and belongs to the field of medicine. Background technique [0002] A cold is an infection of the upper respiratory tract mucosa caused by many different types of viruses. The main symptoms are nasal congestion, sneezing, mild sore throat, and fever. Systemic symptoms include general discomfort, headache, and myalgia. Because there is no specific treatment at all, it is not necessary to make the virus firm, and only symptomatic treatment can be used to promote the relief of many symptoms of the cold. Since there is still no one drug to alleviate the coexisting symptoms, various compound preparations have been listed one after another. These compound preparations are composed of drugs with different curative effects to reli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4402A61K31/167A61K31/137A61K9/30A61K9/48A61P11/00A61P31/12
Inventor 林鹏
Owner COSCI MED TECH CO LTD
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