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Copper-threonine and preparation method and application thereof

A technology of copper threonine and threonine, which is applied in the field of amino acid chelate and its preparation, can solve the problems of difficult solubility of solid threonine, destruction of the activity of nutrients, low biological titer, etc. The effect of fast growth, absorption rate and high biological titer

Active Publication Date: 2009-12-09
XINGJIA BIO ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As an essential trace element for humans and animals, inorganic salts of copper are mostly used as animal feed additives at present. Animals must pass through various biological barriers to absorb and utilize the inorganic salts. The absorption rate is low, the addition amount is large, and the biological potency is low. Most of them pollute the environment after being excreted by feces, and have a destructive effect on the activity of other nutrients (such as vitamins, etc.) in the feed
There are also situations where solid threonine and inorganic copper are used together as feed additives, but the operation process is complicated and the solubility of solid threonine is relatively difficult

Method used

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  • Copper-threonine and preparation method and application thereof
  • Copper-threonine and preparation method and application thereof
  • Copper-threonine and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A threonine copper finished product of the present invention is prepared through the following steps: firstly open the nitrogen valve, replace the air in the reactor, and then under the protection of nitrogen, first take 40.55g of threonine and put it into a tank containing 100g of reaction water. Fully stir in the reaction kettle, then put 42.5g of copper sulfate pentahydrate, maintain the pH value of the reaction mixture at 90°C with 13.48g of sodium hydroxide, react for 2.5 hours under normal pressure, and then send the reaction product to In the concentration tank, at 0.25kgf / cm 2 Under the vacuum degree and the concentration temperature of 90°C, concentrate in vacuum for 45 minutes. After the product is viscous, the concentrate is fed into the tray, dried in an air flow at 120°C, and crushed to prepare copper threonine. finished product.

[0029] Gel filtration chromatography (GB / T 13080.2-2005) is used to detect the chelation rate in the finished product of the r...

Embodiment 2

[0036]A threonine copper finished product of the present invention is prepared through the following steps: firstly open the nitrogen valve, replace the air in the reaction kettle, then under the protection of nitrogen, first take 47.51g threonine and put it into a tank containing 150g reaction water Fully stir in the reaction kettle, then add 35.42g of copper sulfate monohydrate, maintain the pH value of the reaction mixture at 90°C with 11.21g of sodium hydroxide, react for 2h under normal pressure conditions, and then wash the reaction product with propanol After extraction for 30 minutes, the volume ratio of propanol to reaction product is 10:1, and the precipitate after extraction is flash-dried at 120° C. for an instant, and crushed to prepare the finished product of copper threonine.

[0037] Gel filtration chromatography (GB / T 13080.2-2005) is used to detect the chelation rate in the finished product of the reaction product, and the values ​​are all above 80%.

[0038]...

Embodiment 3

[0044] A threonine copper finished product of the present invention is prepared through the following steps: first open the nitrogen valve, replace the air in the reaction kettle, then under the protection of nitrogen, first take 238Kg threonine and put it into a tank containing 1000kg of reaction water. Fully stir in the reaction kettle, then add 250Kg copper sulfate pentahydrate, maintain the pH value of the reaction mixture at 90°C with 80kg sodium hydroxide, react for 2 hours under normal pressure, and then send the reaction product to the concentration tank , at 0.5kgf / cm 2 Vacuum concentration at 80°C for 30 minutes. After the product is viscous, the concentrate is fed into a tray, dried by airflow at 120°C for an instant, and crushed to prepare the finished product of copper threonine.

[0045] Gel filtration chromatography (GB / T 13080.2-2005) is used to detect the chelation rate in the finished product of the reaction product, and the values ​​are all above 80%.

[00...

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Abstract

The invention discloses a threonine chelate of copper-threonine and the preparation method comprises the following steps: mixing the copper sulfate or the crystalline hydrate of copper sulfate with threonine aqueous solution according to a mole ratio of (0.5-1.1):2 to react at 60-100 DEG C and with a pH value of 4-8 for 0.5-6h under protection of inert gas and obtaining a reaction product; vacuum concentrating or extracting the reaction products with an organic solvent, drying and crushing to obtain the finished product copper-threonine. The copper-threonine of the invention can be used as the animal feed additive so that the aim to effectively promote the growth of the animal, strengthen the resistance of the animal and improve the utilization efficiency of animal feed can be realized.

Description

technical field [0001] The invention relates to a feed additive and a preparation method thereof, in particular to an amino acid chelate compound, a preparation method and application thereof. Background technique [0002] Threonine is an important nutritional enhancer, which can strengthen the nutrition of grains, cakes, dairy products, etc. Threonine, like tryptophan, also has the functions of restoring human fatigue and promoting growth and development. In medicine, because the structure of threonine contains hydroxyl groups, it has a water-holding effect on human skin. After combining with oligosaccharide chains, it can play an important role in protecting cell membranes; threonine can also promote phospholipid synthesis and fatty acid oxidation in the body , and its preparation has medicinal effects such as promoting human growth and anti-fatty liver, and is often used as a component of compound amino acid infusion. At the same time, threonine is also the basic raw ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/76C07C229/22C07C227/16A23K1/16A23K20/142
Inventor 黄逸强
Owner XINGJIA BIO ENG CO LTD
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