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Ready-to-use herba houttuyniae ophthalmic gel

A technology of Houttuynia cordata extract and gel, which is applied in the field of eye-use instant gel preparations and Houttuynia cordata eye-use instant gel preparations, and can solve the problem of increasing the action time of the drug, reducing the action time of the drug, and lasting damage to the eye tissue. and other problems, to achieve the effect of improving bioavailability, good slow release characteristics and good fluidity

Inactive Publication Date: 2009-11-18
BEIJING HERUN INNOVATION PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to tear dynamics, ophthalmic solutions have a very short residence time on the ocular surface, and the amount of drug absorbed is usually only a small part of the administered dose, even if the drug is on the surface of the eyeball, because of blinking and dilution of tears, the drug The effective concentration of the drug is reduced, and the action time of the drug is reduced, so the solution must be administered repeatedly to ensure the effective drug concentration, increase the action time of the drug, and achieve a higher drug absorption. This requires frequent eye drops, but frequent Drug administration can easily cause lasting damage to eye tissue, it is inconvenient to use, and it is difficult for patients to persist

Method used

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  • Ready-to-use herba houttuyniae ophthalmic gel
  • Ready-to-use herba houttuyniae ophthalmic gel
  • Ready-to-use herba houttuyniae ophthalmic gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Prescription: Houttuynia cordata 2kg, gellan gum 12g

[0068] Preparation method: take Houttuynia cordata, add 6 times the amount of water, steam distillation, collect 750ml of distillate, and set aside; take 200ml of water for injection, add gellan gum, stir well, put it in a boiling water bath, stir until clear, add polysorbate Ester 80 1g, stir evenly, add triethanolamine and glycerin, add ethylparaben 0.6g, stir well, add the above distillate while stirring, pass through a microporous membrane, add water for injection to 1000ml, pass through a microporous membrane, Aseptic subpackaging, ready to use.

Embodiment 2

[0070] Prescription: Houttuynia cordata 6kg, gellan gum 10g

[0071] Preparation method: take houttuynia cordata, add 6 times the amount of water, steam distillation, collect 1600ml of distillate, and set aside; take 200ml of water for injection, add gellan gum, stir evenly, put in boiling water bath, stir until clear, add triethanolamine and mannitol, then add 1g of benzalkonium chloride, stir until clear, heat to 70°C, filter, add the above-mentioned houttuynia cordata distillate while stirring, heat to 70°C, filter, add water for injection to 2000ml, finely Porous filter membrane, aseptically packaged, ready to use.

Embodiment 3

[0073] Prescription: Houttuynia cordata 1kg, gellan gum 14g

[0074] Preparation method: take houttuynia cordata, add 8 times the amount of water, steam distillation, collect 1500ml of distillate, and set aside; take 400ml of water for injection, add gellan gum, stir evenly, put in boiling water bath, stir until clear, add citron acid and glycerin, then add 0.4g methylparaben and 0.4g propylparaben, stir until clear, heat to 70°C, filter, add the above Houttuynia cordata distillate while stirring, filter, add water for injection to 2000g, filter through a microporous membrane, let cool, and pack aseptically.

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Abstract

The invention discloses a ready-to-use herba houttuyniae ophthalmic gel preparation, belonging to the field of traditional Chinese medicines. The active ingredient of the preparation is from herba houttuyniae and the gel base material of the preparation mainly comprises gellan gum accounting for 0.4-0.7 percent of the total weight. The technical scheme overcomes the deficiencies that the prior herba houttuyniae ophthalmic preparation has low bioavailability, inconvenient use, short retention time, and the like and has the effects of reducing dose, prolonging the retention time in eyes, having convenient use and accurate dose, and the like.

Description

technical field [0001] The invention relates to an instant ophthalmic gel preparation of houttuynia cordata, in particular to an instant ophthalmic gel preparation with gellan gum as the main gel base material, belonging to the field of traditional Chinese medicine. Background technique [0002] The traditional Chinese medicine Houttuynia cordata is the dried aboveground part of the Sanbaiaceae plant Houttuynia chinensis, which has the effects of clearing away heat and detoxification, eliminating carbuncle and expulsion of pus, diuresis and treating stranguria. . Houttuynia cordata tablets and injections have been widely used clinically. Houttuynia cordata eye drops have been used in eye applications, mainly for the treatment of conjunctivitis, keratitis, trachoma, etc. [0003] Houttuynia cordata contains flavonoids such as agaricine, quercitrin, isoquercitrin, renoside, hyperoside, afuglutin, and rutin, and the main components of the volatile oil are capryl acetaldehyde ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K9/00A61K47/36A61K47/38A61K47/40A61P27/02
Inventor 朴美善王广录
Owner BEIJING HERUN INNOVATION PHARMA TECH DEV
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