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Ready-to-use puerarin ophthalmic gel

A technology for puerarin and ophthalmic use, applied in the field of traditional Chinese medicine, can solve the problems of short residence time, inconvenient use, reduced drug action time, etc., and achieves the effects of strong gel forming ability, good acid resistance and heat resistance, and high transparency.

Inactive Publication Date: 2009-11-18
BEIJING HERUN INNOVATION PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to tear dynamics, ophthalmic solutions have a very short residence time on the ocular surface, and the amount of drug absorbed is usually only a small part of the administered dose, even if the drug is on the surface of the eyeball, because of blinking and dilution of tears, the drug The effective concentration of the drug is reduced, and the action time of the drug is reduced, so the solution must be administered repeatedly to ensure the effective drug concentration, increase the action time of the drug, and achieve a higher drug absorption. This requires frequent eye drops, but frequent Drug administration can easily cause lasting damage to eye tissue, it is inconvenient to use, and it is difficult for patients to persist

Method used

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  • Ready-to-use puerarin ophthalmic gel
  • Ready-to-use puerarin ophthalmic gel
  • Ready-to-use puerarin ophthalmic gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Prescription: Puerarin 10g, Gellan Gum 6g

[0053] Preparation method: Take 800ml of water for injection, add gellan gum, stir evenly, place in a boiling water bath, stir until clear, add 12g of boric acid, 0.6g of borax, 0.8g of ethyl paraben, stir until clear, heat to 70°C, Filter, add puerarin, pass through a microporous membrane, add water for injection to 1000g, autoclave at 120°C for 20 minutes, let cool, and pack aseptically to obtain the product.

Embodiment 2

[0055] Prescription: Puerarin 20g Gellan Gum 20g

[0056] Preparation method: Take 4000ml of water for injection, add gellan gum, stir evenly, place in a boiling water bath, stir until clear, add triethanolamine and mannitol, then add 2g of benzalkonium chloride, stir until clear, heat to 70°C, filter After stirring, add puerarin, filter, add water for injection to 5kg, pass through a microporous membrane, and pack aseptically.

Embodiment 3

[0058] Prescription: Puerarin 40g, Gellan Gum 14g

[0059] Preparation method: Take 1600ml of water for injection, add gellan gum, stir evenly, place in a boiling water bath, stir until clarified, add citric acid and glycerin, then add 0.4g of methylparaben and 0.4g of propylparaben, Stir until clear, heat to 70°C, pass through a microporous membrane, add puerarin while stirring, heat to 70°C, filter, add water for injection to 2000g, autoclave at 120°C for 20 minutes, let cool, and pack aseptically , that is.

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Abstract

The invention discloses a ready-to-use puerarin ophthalmic gel preparation belonging to the field of traditional Chinese medicines. The active ingredient of the preparation is puerarin, and the gel base material of the preparation mainly comprises gellan gum accounting for 0.4-0.7 percent of the total weight. The technical scheme overcomes the deficiencies that the prior puerarin ophthalmic preparation has low bioavailability, inconvenient use, short retention time, and the like and has the effects of reducing dose, prolonging the retention time in eyes, having convenient use and accurate dose, and the like.

Description

technical field [0001] The invention relates to an instant ophthalmic gel preparation of puerarin, in particular to an instant ophthalmic gel preparation with gellan gum as the main gel base material, belonging to the field of traditional Chinese medicine. Background technique [0002] Puerarin is an isoflavone compound extracted from Pueraria puerariae or Pueraria puerariae, chemical name: 8-β-D-glucopyranose-4′, 7-dihydroxyisoflavone. Modern pharmacology shows that it has the effects of increasing coronary blood flow, expanding cerebral blood vessels, and improving microcirculation. In recent years, puerarin has been widely used in the treatment of ophthalmic diseases. Puerarin eye drops made with puerarin as the main drug are mainly used to treat glaucoma and ocular hypertension, etc., and have good clinical effects. [0003] As a traditional dosage form, puerarin eye drops has the advantages of convenient use, good compliance and low price, but its shortcoming of drug ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/7048A61K47/36A61K47/38A61K47/40A61P27/02A61P27/06
Inventor 朴美善王广录
Owner BEIJING HERUN INNOVATION PHARMA TECH DEV
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