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A kind of traditional Chinese medicine compound preparation for treating congestive heart failure and preparation method thereof

A compound preparation and heart failure technology, applied in the field of medical preparations, can solve the problems of no significant breakthrough in the clinical efficacy of traditional Chinese medicine, no breakthrough progress, restricting the development of heart failure, etc., to increase coronary blood flow, High yield and the effect of improving hemodynamic disturbance

Inactive Publication Date: 2012-02-01
SHANDONG UNIV QILU HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the clinical curative effect of traditional Chinese medicine has not achieved a significant breakthrough, especially for the treatment of severe and refractory heart failure, it has not achieved a dominant position, and it is only used as an auxiliary treatment and cannot compete with western medicine.
In terms of observation indicators, due to the lack of uniformity, the development of traditional Chinese medicine in the treatment of heart failure has been seriously restricted.
[0006] Reviewing the literature of traditional Chinese medicine, due to the limited understanding of the traditional etiology and pathogenesis, in addition to warming the yang, promoting blood circulation, diuresis, there are other methods of treatment such as purging the lung, nourishing yin, and replenishing qi. Although the research results also prove that it can improve myocardial contractility , to improve symptoms and other effects, but did not bring breakthrough progress

Method used

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  • A kind of traditional Chinese medicine compound preparation for treating congestive heart failure and preparation method thereof

Examples

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Effect test

preparation example Construction

[0049] The preparation method of the dropping pill of the present invention comprises the following steps: add 1500g Cyperus cyperi, 1500g Asarum, 1500g Notopterygium, 1500g Chuanxiong and 1500g Radix Notoginseng, add 5-7 times the amount of water, put it into a multifunctional extraction tank, and keep the air pressure at 0.04 -0.06mPa, decoct for 2 hours, extract its water-soluble components; repeat the above steps to extract again for 1.5 hours, and filter the extract through a 100-mesh sieve; use macroporous adsorption resin to refine the filtrate, and elute with ethanol; the eluate is concentrated under reduced pressure to The density is 1.33-1.35, the input air pressure is 0.04-0.06mPa, the vacuum degree is -0.076~-0.088mPa, and it is left to stand for later use; the remaining medicinal materials are 1500g ginseng, 1500g salvia miltiorrhiza, 1500g safflower, 1500g atractylodes rhizome, 1500g angelica, and 1500g peach kernel , 1500g red peony, 1500g schisandra, 1500g cinna...

Embodiment 2

[0071] Embodiment 2: Feng Mou, female, 54 years old, with a history of coronary heart disease for 3 years, electrocardiogram: myocardial insufficiency, atrial fibrillation. Main clinical complaints: dyspnea when sitting quietly, inability to lie down, fatigue and weakness, cough with white sputum, severe edema of both lower extremities, blue tongue, deep and thready pulse. Clinical diagnosis: coronary heart disease, angina pectoris, atrial fibrillation, heart failure, cardiac function class III (NYHA); pulmonary infection. Take decoction of the present invention, use following formula: 15g of ginseng, 10g of salvia miltiorrhiza, 15g of safflower, 15g of Rhizoma Cyperi, 10g of Atractylodes macrocephala, 15g of angelica, 20g of peach kernel, 10g of red peony, 10g of schisandra, 15g of Sanqi, 20g of cinnamon, 10g of aconite, Radix Ophiopogon japonicus 15g, Radix Astragali 20g, Asarum 10g, Notopterygium 10g, Caulis Spatholobus 20g, Atractylodes 15g, Toad Yi 10g, Ginkgo biloba 5g, ...

Embodiment 3

[0072] Example 3: Patient Shen, male, 65 years old, has a history of hypertension and coronary heart disease for 3 years, was observed for acute myocardial infarction by thrombolytic therapy, was discharged two months later, and still had chest tightness, shortness of breath, fatigue, etc. Discomfort, the patient has been bedridden for a long time, unable to move on the ground, the condition worsens after a little activity, the electrocardiogram shows old myocardial infarction, and ST-T changes, echocardiography shows left ventricular diastolic and systolic dysfunction, coronary angiography shows coronary atherosclerosis, vascular Severe stenosis was performed concurrently with PCI. Turn Chinese medicine treatment with heart failure, heart function III level (NYHA) afterwards, take the Chinese medicine pill prepared by the present invention, use following formula:

[0073] 20g ginseng, 15g salvia miltiorrhiza, 15g safflower, 10g Cyperus cyperi, 10g Atractylodes macrocephala, 2...

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Abstract

The invention discloses a Chinese herbal medicine compound preparation for treating congestive heart failure and a preparation method thereof. The Chinese herbal medicine compound preparation comprises various components according to the parts by weight: 10-30 parts of ginseng, 10-30 parts of the root of red-rooted salvia, 10-30 parts of safflower, 10-30 parts of rhizoma cyperi, 10-30 parts of bighead atractylodes rhizome, 10-30 parts of angelica, 10-30 parts of peach kernel, 10-30 parts of red paeonia, 10-30 parts of schisandra chinensis, 10-30 parts of pseudo-ginseng, 10-30 parts of cinnamon, 10-15 parts of monkshood, 10-30 parts of ophiopogon root, 10-30 parts of milk weteh, 10-30 parts of asarum, 10-30 parts of notopterygium root, 10-30 parts of spatholobus stem, 10-30 parts of rhizoma atractylodis, 10-15 parts of toad coat, 10-30 parts of folium ginkgo, and 10-30 parts of the rhizome of chuanxiong. The Chinese herbal medicine compound preparation can inhibit platelet aggregation and thrombosis, improves microcirculation, increases coronary blood flow, has the function of cardiac stimulant, can increase cardiac and cardiac index, has the efficacy of dilating blood vessels and depressurization, and can be effectively used for treating patients with clinical congestive heart failure.

Description

technical field [0001] The invention relates to a medical preparation containing components derived from plants, animals or minerals, in particular to a traditional Chinese medicine compound preparation for treating congestive heart failure and a preparation method thereof. Background technique [0002] The pathophysiological changes of congestive heart failure (CHF) are a very complex dynamic process, including compensatory changes in nerve and humoral regulation factors, loss of myofibrils, disordered cytoskeleton, cardiomyocyte apoptosis, Increased collagen synthesis, muscle cell Ca 2+ Disturbance of homeostasis, changes in cell membrane receptor density, activation of cytokines, changes in cell information transmission, etc., as well as the remodeling of myocardial structure and the reduction of myocardial systolic performance caused by a series of changes, eventually lead to heart failure. During this process, almost every metabolic link of the cells has changed, and a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61K9/20A61K9/48A61K9/10A61P9/04A61K35/56A61K35/65
Inventor 陈玉国吕瑞娟李晓鲁徐峰孙祎边园王文君唐梦熊
Owner SHANDONG UNIV QILU HOSPITAL
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