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Wet-process wall breaking method of lucidum spore powder

A Ganoderma lucidum spore powder and wet method technology, which is applied in the direction of medical formulas, medical preparations with non-effective ingredients, non-effective ingredients of polymer compounds, etc., can solve the problem of increasing the production cycle and cost of spore powder, unsatisfactory wall breaking effect, excessive Oxidation value exceeds the standard and other problems, to achieve the effect of facilitating technology promotion and industrial production, increasing disinfection, sterilization and impurity removal operations, and shortening the production cycle

Inactive Publication Date: 2009-09-09
NANJING NORMAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For ordinary crushing machines, such a particle size is already the minimum limit size of crushing, so the wall breaking effect is not ideal
Ganoderma lucidum spore powder is rich in unsaturated fatty acids and other components that are easily oxidized. Therefore, if the traditional method is used to break the wall and store it improperly, the active ingredients will be oxidized, mildewed, and odor will be generated. The peroxide value and acid value will seriously exceed the standard. In the process of breaking the wall, it is necessary to take anti-oxidation measures for the broken-wall spore powder in time, or use drying and sterilization equipment to dry and sterilize or add natural antioxidants, nitrogen-filled inner packaging and other measures to prevent oxidation. The processing procedure is complicated and increases Spore powder production cycle and cost

Method used

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  • Wet-process wall breaking method of lucidum spore powder
  • Wet-process wall breaking method of lucidum spore powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047]Example 1, soak 10 grams of natural Ganoderma lucidum spore powder with 75% ethanol for 10 minutes, filter with suction, wash with purified water twice for later use. Weigh 10 grams of hydroxyethyl-β-cyclodextrin and 20 grams of microcrystalline cellulose, add 30 milliliters of water, grind them evenly, add the processed spare Ganoderma lucidum spore powder, grind for 1 hour, and then place them in an oven at 50°C to dry , crushed through a 100-mesh sieve to obtain 40 grams of powdered product, and the wall-breaking rate of ganoderma lucidum spore powder is over 90%.

Embodiment 2

[0048] Example 2, weigh 500 grams of natural Ganoderma lucidum spore powder, soak it in 75% ethanol for 20 minutes, filter it with suction, wash it twice with pure water, add 250 grams of β-cyclodextrin and 1.5 liters of pure water to the Ganoderma lucidum spore powder, and mix well Then pour it into a colloid mill and grind it. The temperature of the system will naturally rise to 45°C. Grind it for 1 hour, then place it in an oven at 50°C and dry it under reduced pressure, and crush it through a 100-mesh sieve to obtain 740 grams of broken spore powder. The broken wall of Ganoderma lucidum spores The rate is above 90%.

Embodiment 3

[0049] Example 3 is basically the same as Example 2, but adding 500 grams of hydroxypropyl-β-cyclodextrin and 250 grams of microcrystalline cellulose and 2.0 liters of purified water to obtain 1250 grams of Ganoderma lucidum spore powder-broken inclusion complex product .

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Abstract

The invention relates to a wet-process wall breaking method of lucidum spore powder, comprising the steps of (1) soaking lucidum spore powder with ethanol and filtering; (2) washing with purified water and removing impurity; (3) adding mixing solids to mix with lucidum spore powder, and adding purified water 1-5 times of the total mass of solids into even mixed liquor, and grinding into mixed liquor and (4) drying, grinding and sieving to obtain solid spore powder products, wherein the mass ratio of the mixing solids and lucidum spore powder is 0.5-6:1;, the mixing solids are peroral cyclodextrin or mixture of peroral cyclodextrin and edible solid auxiliary materials or pharmaceutical solid auxiliary materials, and the mass ratio of the mixing solids and lucidum spore powder is 0.5-2:1. In the invention, the wall-broken rate of the lucidum spore powder is high, and stable effective ingredients in the lucidum spore powder are ensured. The invention has advantages of more convenient processing, sanitation, safety, short production period, few time consumption, high production rate, convenient operation, low investment of devices, and benefit for industrialized production.

Description

technical field [0001] The invention relates to a method for breaking walls of ganoderma lucidum spore powder by a wet method, and belongs to the technical field of wall breaking of ganoderma lucidum. Background technique [0002] Ganoderma lucidum is a fungus belonging to the Basidiomycetes Polyporaceae family and is a good medicinal fungus. Li Shizhen of the Ming Dynasty believed in Compendium of Materia Medica that Ganoderma lucidum has the functions of clearing heat and detoxifying, strengthening the heart, nourishing the kidney and protecting the liver, nourishing and strengthening the body, strengthening the body, beautifying the skin, calming the nerves and replenishing essence. Ganoderma lucidium spores are extremely tiny spores ejected from the cap of Ganoderma lucidum during the growth and maturity stage of the fruiting body of Ganoderma lucidum. It condenses all the essence of Ganoderma lucidum and contains all the genetically active substances of Ganoderma lucidu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/074A61K47/40A61K47/38A61P35/00A61P37/04A61P39/02A61P3/10A61P1/16A61P17/00A61P39/06A61P25/20A61P11/06A61P11/10A61P11/14
Inventor 任勇安翠翠朱文杰裴会娜吴玲
Owner NANJING NORMAL UNIVERSITY
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