Fermentation preparation technology of granular threonine

Abstract

The invention belongs to the technical field of threonine production, and belongs to a fermentation preparation technology of granular threonine. The technology comprises the followings steps: firstlycentrifuging threonine fermentation liquor by a disc centrifuge, collecting supernate, performing filtering through a ceramic membrane, concentrating filtrate, adjusting pH with sulfuric acid, heating the filtrate to 75 DEG C, performing separation by a horizontal spiral centrifuge, removing precipitate, and collecting supernate; performing filtering through an ultrafiltration membrane, collecting filtrate, crystallizing the filtrate through an intermittent single-effect concentrating crystallizing pan, centrifuging and collecting crystals, then drying the crystals at the temperature of 120 DEG C, compressing the crystals into flake crystals, putting the flake crystals into a granulation tower, performing drying by a fluidized bed, performing crushing and granulation, sieving, collectinggranules with target grain sizes, and performing packaging, so as to obtain the granular threonine. The technology has the advantages that threonine is prepared into granules, the flowability can be improved, the threonine is convenient to store and transport, the solubility is convenient to control, and the quality and the additional value of threonine are improved.

Description

technical field [0001] The invention belongs to the field of amino acid production, and in particular relates to a fermentation preparation process of granular threonine. Background technique [0002] Threonine (Threonine, abbreviated as Thr), scientific name 2-amino-3-hydroxybutyric acid, belongs to aliphatic amino acid, slightly sweet, named for its structure similar to threose, is a kind of human, animal and plant protein Essential amino acids are mainly used in medicine, chemical reagents, and nutritional enhancers. They can strengthen dairy products, restore human fatigue, and promote growth and development. In recent years, with the development of the economy, the market demand for threonine has continued to grow steadily, and it is one of the amino acid varieties with the fastest growing demand. Especially, the use in chemistry and biochemistry, food additives, feed additives, etc. has grown rapidly. It replaces tryptophan and becomes the third fastest-growing amino ...

AI Technical Summary

Problems solved by technology

At present, domestic threonine manufacturers commonly use microbial fermentation, but there are still some disadvantages such as low fermentation yield and high raw material cost; the extraction process of threonine is that the threonine fermentation liquid is intercepted and filtered by a ceramic membrane to filter the bacterial protein , the ceramic membrane filtrate is concentrated and crystallized by the evaporator, that is, the threonine fermentation broth is filtered and concentrated with a ceramic membrane. When it is concentrated to 5-7 times, the flux of the ceramic membrane begins to decline due to the increase in the concentration of bacterial protein in the fermentation broth. Recover threonine, start adding water at this time, the amount of water added is 20% of the volume of the fermentation broth, the fermentation broth is finally concentrated to 9-10 times, the filtrate of the ceramic membrane is concentrated and crystallized by a four-effect evaporator, and finally dried and packaged

However, in this process, the feed liquid concentrated 9-10 times by the ceramic membrane also contains a certain amount of threonine. body protein, resulting in reduced purity