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Medicine composition for treating melancholia using multi-target receptor after-action mechanism

A technology of action mechanism and composition, which can be applied to drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as increased suicide rate and decreased libido

Inactive Publication Date: 2009-06-10
戚郁芬 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the antidepressants already on the market have side effects of varying degrees, such as: increased suicide rate, headache, dizziness, dizziness, insomnia, drowsiness, tinnitus, dry mouth, anorexia, increased appetite, weight gain, blood pressure rise, gastrointestinal Discomfort, nausea, nausea, vomiting, indigestion, diarrhea, constipation, leg pain, skin rash, tremor, cramps, sweating, edema, decreased libido, impotence, etc.

Method used

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  • Medicine composition for treating melancholia using multi-target receptor after-action mechanism
  • Medicine composition for treating melancholia using multi-target receptor after-action mechanism
  • Medicine composition for treating melancholia using multi-target receptor after-action mechanism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] see figure 1 , which is a schematic flow chart of the method for preparing the medicine of Example 1 of the present invention. exist figure 1 In the process, 20kg of ginseng was crushed first, then heated and extracted with 70% ethanol solution, separated and purified by upper column chromatography, and dried to obtain 0.8kg of ginseng extract containing 120g ginsenosides (Rg1+Rb1); then, 10kg The broken licorice was soaked at room temperature for 12 hours, extracted with water and alcohol precipitation, concentrated and dried to obtain 2 kg of licorice extract containing 200 g of glycyrrhizic acid; after that, 150 g of ginseng extract obtained by the above method and 200 g of licorice extract were pulverized and mixed uniformly Afterwards, obtain 350g (containing 22.5g ginsenoside Rg1+Rb1 and 20g glycyrrhizic acid) the pharmaceutical composition of scheme one of the present invention.

Embodiment 2

[0070] see figure 2 , which is a schematic flow chart of the method for preparing the drug of Example 2 of the present invention. exist figure 2 3.96g of glycyrrhetinic acid with a purity of 96% and 200g of the ginseng extract obtained in Example 1 were pulverized and mixed uniformly to obtain 203.96g (containing 30g ginsenosides Rg1+Rb1 and 3.8g glycyrrhetinic acid). The pharmaceutical composition of the second invention scheme.

Embodiment 3

[0072] see image 3 , which is a schematic flow chart of the method for preparing the medicine of Example 3 of the present invention. exist image 3 3.4g of prepared ginsenoside Rg1 with a purity of 90%, 7.8g of ginsenoside Rb1 with a purity of 90%, and 36.8g of 95% glycyrrhizic acid were pulverized and mixed uniformly to obtain 48g (containing 10g of ginsenoside Rg1+Rb1 and 35g glycyrrhizic acid) the pharmaceutical composition of the third scheme of the present invention.

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Abstract

The invention discloses an oral medicament or health care food for treating melancholia with acting mechanism after being made into multiple-target drone receptor with raw materials of ginsenoside (Rg1+Rb1), glycyrrhizic acid and Chinese date cAMP. According to the experiment to prove, the medicament composition of the invention can obviously reduce the small mouse suspension tail dead time and body temperature descend induced by reserpine; obviously improve the rat horizontal and vertical movement increase and rat learning and memory function abatement caused by buibus olfactorius damage; meanwhile can improve saccharose drinking water amount decrease and body weight descend caused by unpredictable long term stress stimulus, can improve the rat horizontal and vertical movement decrease and obvious increase of the NE and 5-HT content in the rat cerebral cortex caused by unpredictable long term stress stimulus. The experiment result proves that the medicament has remarkable anti-melancholia efficacy, comparing to the current medicament Paroxetine for treating the melancholia in prior art.

Description

technical field [0001] The present invention relates to a group of raw materials containing ginsenosides Rg1, Rb1, glycyrrhizic acid and jujube cyclic adenosine monophosphate (jujube cyclic adenosine monophosphate, jujube cAMP), which are made into multi-target receptors to treat depression. The medicine, especially relates to an oral medicine or health food for treating depression with clear functional ingredients, obvious curative effect, high safety for long-term use, and avoiding side effects such as strong vomiting. Background technique [0002] Depression is a common disease. According to statistics, about 25% of women in the general population have experienced depression in their lifetime, and about 10% of men have experienced depression (Zhang Chunxing: "Modern Psychology") . According to the data provided by the World Health Organization (WHO): the incidence rate of depression in the world is about 11%. It will rise to become the second most common disease in the ...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K31/7076A61P25/24
Inventor 张作光
Owner 戚郁芬
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