Preparation method of blood vessel support or cardiac valve surface coating with good biocompatibility

Abstract

The invention discloses a preparation method of a surface coating of intravascular stents or cardiac valves with excellent biocompatibility, which includes the steps: A. the preparation of a coating solvent: heparin is dissolved in deionized water, the pH value thereof is adjusted to 7 to 8 and then an endothelial cell growth factor is added to form a heparin / growth factor solution; collagens are dissolved in acetum to form a collagen solution; B. dip-coating: the intravascular stents or the cardiac valves are immersed in the heparin / growth factor solution and a layer of heparin / growth factor is dipped and coated on the surface of the intravascular stents or the cardiac valves, and then the intravascular stents or the cardiac valves are taken out for being cleaned by the deionized water and being dried by nitrogen gas; and the intravascular stents or the cardiac valves are immersed in the collagen solution, coated with a layer of collagen, and taken out for being cleaned by the deionized water and being dried by nitrogen gas; the steps of dip-coating by the use of the heparin / growth factor and the collagen are repeated in sequence for 1 time to 60 times; finally the step of dip-coating by the use of the heparin / growth factor is carried out again to obtain the surface coating with excellent biocompatibility of the intravascular stents or the cardiac valves. The intravascular stents or the cardiac valves prepared have excellent biocompatibility and low preparation cost.

Description

Technical field [0001] The invention relates to a method for biochemically modifying the surface of a vascular stent and a heart valve material. Background technique [0002] The incidence of cardiovascular disease is increasing year by year. Atherosclerosis causes stenosis or obstruction of the lumen is the main cause of ischemic heart disease (coronary heart disease); heart valve disease is due to congenital or acquired reasons The resulting heart valve disease causes heart blood flow disorder-based disease. [0003] The latest research proves that endothelial cells are very important for the function of blood vessels: 1) The intact endothelial cell layer will secrete nitric oxide and other molecules to inhibit the excessive proliferation of smooth muscle, and the secretion mechanism of the damaged endothelial cell layer is out of balance, leading to the excessive proliferation of smooth muscle and resulting in vascular 2) The intact endothelial cell layer will secrete an...

AI Technical Summary

Problems solved by technology

But there are still some problems: with the prolongation of drug-coated stent implantation, the drug inhibits the proliferation of smooth muscle cells (the main cause of restenosis) and also inhibits the proliferation of endothelial cells, and the surface of the stent cannot form a complete endothelium. The anticoagulant function on the surface of the stent is poor; and the final drug release is exhausted and the complete endothelial cell layer that has the anticoagulant effect and inhibits the proliferation of smooth muscle cells is still not formed, and the possibility of restenosis in the vascular stent thereafter is significantly increased

[0005] At present, there are about 200,000 patients in our country who need artificial heart valve replacement surgery every year due to serious valvular disease. Most of these patients are young and middle-aged. If the valve cannot be replaced in time, it will cause immeasurable losses to the society.

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