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Method for preparing antimicrobial type epidermis repair material

An epidermal repair and antibacterial agent technology, applied in the field of preparation of antibacterial epidermal repair materials, can solve the problems of limited use of organic antibacterial agents, human and environmental hazards, poor antibacterial effect, etc., and achieves high migration speed and safety. High, long-acting effect

Inactive Publication Date: 2009-01-28
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although organic antibacterial agents have good antibacterial effect on fungi, their antibacterial effect is poor, and their thermal stability is low. Generally, they can only be used at lower temperatures, and their decomposition or volatiles may also cause harm to the human body and the environment. certain hazard
In addition, due to the emergence of highly resistant pathogenic bacteria in recent years, the use of organic antibacterial agents has been largely restricted.

Method used

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  • Method for preparing antimicrobial type epidermis repair material
  • Method for preparing antimicrobial type epidermis repair material
  • Method for preparing antimicrobial type epidermis repair material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: the impact of antibacterial agent concentration on material antibacterial property

[0023] Remove the terminal peptide through enzymatic digestion to obtain incomplete collagen without antigenicity, dissolve the collagen swelling solution and chitosan respectively with 0.05M acetic acid, and prepare a collagen solution with a concentration of 0.6% (wt) and a concentration of 0.6% (wt) Chitosan solution, then add silver-loaded inorganic antibacterial agent powder HN-300 with sodium phosphate crystals as the carrier in the chitosan solution, after stirring, ultrasonication, and stirring again, mix with the chitosan solution at a ratio of 9:1 The mass ratio is fully stirred and mixed to obtain the collagen / chitosan / HN-300 dispersion liquid, wherein the content of HN-300 is 10%, 7.5%, 5%, 2.5% (wt), and the prepared dispersion liquid is pressed by 3cm 2 / g Spread the film evenly on a polytetrafluoroethylene plate, and place it in a 37°C oven to dry. Soak in ...

Embodiment 2

[0028]Embodiment 2: the influence of crosslinking agent concentration on material degradation performance

[0029] Remove the terminal peptide through enzymatic digestion to obtain incomplete collagen without antigenicity, dissolve the collagen swelling solution and chitosan respectively with 0.5M acetic acid, and prepare a collagen solution with a concentration of 0.8% (wt) and a concentration of 0.8% (wt) Chitosan solution, then add silver-loaded inorganic antibacterial agent powder FUMAT T200-4 with zirconium phosphate as carrier in the chitosan solution, so that the content of FUMATT200-4 is 10% (wt). After stirring, ultrasonication, and stirring again, it was fully stirred and mixed with the chitosan solution at a mass ratio of 7:3 to obtain a collagen / chitosan / FUMAT T200-4 dispersion, which was dried to obtain a 10% (wt) FUMATT200 Collagen of -4: the composite film of chitosan=7: 3, cross-linking 12h obtains cross-linking degree in the glutaraldehyde aqueous solution of ...

Embodiment 3

[0030] Example 3: In vitro biological safety evaluation of composite membranes containing different concentrations of antibacterial agents

[0031] Remove the terminal peptide through enzymatic digestion to obtain incomplete collagen without antigenicity, dissolve the collagen swelling solution and chitosan respectively with 0.05M acetic acid, and prepare a collagen solution with a concentration of 0.6% (wt) and a concentration of 0.6% (wt) Chitosan solution, then add silver-loaded inorganic antibacterial agent powder HN-300 with sodium phosphate crystals as the carrier in the chitosan solution, after stirring, ultrasonication, and stirring again, mix with the chitosan solution at a ratio of 9:1 The mass ratio is fully stirred and mixed to obtain the collagen / chitosan / HN-300 dispersion liquid, wherein the content of HN-300 is 10%, 7.5%, 5%, 2.5% (wt), and the prepared dispersion liquid is pressed by 3cm 2 / g Spread the film evenly on a polytetrafluoroethylene plate, and place ...

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Abstract

The invention relates to a preparation method for an antibacterial epidermis repairing material, relating to a human body epidermis repairing material; the invention provides a preparation method for an antibacterial epidermis repairing material with antibacterial performance. The preparation method comprises the following steps: respectively dissolving collagen swelling solution and chitosan under acidic condition; respectively compounding collagen solution and chitosan solution according to weight percentage; adding an ag-series inorganic antibacterial agent to the chitosan solution, stirring and ultrasounding; mixing and stirring the mixture of the chitosan solution with antibacterial agent and the collagen solution so as to derive collagen / chitosan / antibacterial agent dispersion liquid; evenly spreading the collagen / chitosan / antibacterial agent dispersion liquid on a polyfluortetraethylene plate and drying; immersing with distilled water to separate the film and the polyfluortetraethylene plate; spreading the film on the surface of the polyfluortetraethylene plate once again and drying to derive collagen / chitosan / antibacterial agent complex film; immersing the collagen / chitosan / antibacterial agent complex film into a crosslinking agent to be cross-linked, washing and drying to derive the antibacterial epidermis repairing material.

Description

technical field [0001] The invention relates to a human skin repair material, in particular to a preparation method of an antibacterial skin repair material. Background technique [0002] Epidermal repair material is a kind of medical dressing used for temporary covering of various wounds and wound surfaces. It can protect wounds from bacterial infection and other external factors, and has the function of protecting wounds and wound surfaces. Therefore, looking for an ideal wound covering has become one of the main research directions for various skin wound treatments at home and abroad. Collagen is the main component of extracellular matrix, which has better biocompatibility than natural biomaterials such as albumin and gelatin, and is conducive to cell adhesion, proliferation and differentiation. The structure of chitosan is very similar to the glycosaminoglycan in the human body, and it has excellent blood compatibility, degradation and antithrombotic properties. Can pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/44
Inventor 张其清王秀燕孙莉萍关嫚
Owner XIAMEN UNIV
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