Nano-composition, preparing method and application thereof

A nano composition and nano technology, applied in the direction of nano structure manufacturing, nano technology, nano technology, etc., can solve the problems of undiscovered nano preparations, improve the encapsulation rate and drug loading, improve the therapeutic effect, and the preparation method is simple Effect

Active Publication Date: 2010-12-08
北大世佳科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The results of domestic and foreign literature search show that there is no report on the use of prolamin carrier materials to encapsulate silybin to make nano-preparations

Method used

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  • Nano-composition, preparing method and application thereof
  • Nano-composition, preparing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Dissolve 100mg of wheat prolamin and 15mg of Poloxamer188 in 12ml of 70% ethanol solution, then add 18.8mg of silibinin (SN), stir magnetically at 1500rpm to dissolve, quickly add 28ml of 1% Poloxamer188 solution, continue to stir for 30min, and remove part of it by rotary evaporation ethanol to obtain the colloidal solution of the nano composition. Add 400 mg of glucose and 200 mg of mannitol to the solution, fully dissolve, and lyophilize to obtain the nanocomposite lyophilized powder injection. After reconstitution with deionized water, the particle size was determined to be 203 nm, and the polydispersity index (PDI) was 0.217.

Embodiment 2

[0047] Dissolve 200mg of wheat prolamin and 30mg of Poloxamer188 in 15ml of 70% ethanol solution, then add 10mg of silibinin (SN), stir magnetically at 2500rpm to dissolve, quickly add 36ml of absolute ethanol, continue to stir for 20min, add 1% pentadiene dropwise 1.2ml of aldehyde solution, continue to stir and solidify for 8-12h, remove part of the ethanol by rotary evaporation, and obtain the colloidal solution of the nanocomposite. Add 200 mg of glucose and 200 mg of mannitol to the solution, fully dissolve, and lyophilize to obtain the nanocomposite lyophilized powder injection. After reconstitution with deionized water, the particle size was determined to be 280 nm, and the polydispersity index (PDI) was 0.112.

Embodiment 3

[0049] Dissolve 120mg of wheat prolamin and 16mg of lecithin in 6ml of 70% ethanol solution, then add 2.4mg of silibinin (SN), stir magnetically at 500rpm to dissolve, quickly add 24ml of absolute ethanol, continue stirring for 30min, add 2% Formaldehyde solution 2.4ml, continue to stir and solidify for 8-12h, remove part of the ethanol by rotary evaporation, and obtain the nanocomposite colloidal solution. Add 100 mg of glucose and 100 mg of mannitol to the solution, fully dissolve, and freeze-dry to obtain the freeze-dried powder injection of the nanometer composition. After reconstitution with deionized water, the particle size was determined to be 480 nm, and the polydispersity index (PDI) was 0.352.

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Abstract

The present invention relates to a new medicine delivery system carrier material, namely liver target nanometer combination that is made from wheat gliadin and silibinin. The preparation method of the nanometer combination is also provided. Coprecipitation of medicine and material in an identical system is achieved in a desolvation way; the nanometer combination colloidal solution that is made inthe method can be produced into freeze-dried power injection after being mixed with the freeze-dried supporting agent acceptable in pharmacy. The nanometer combination can improve blood concentrationof the medicine in liver region so that effect of the hepatitis cure medicine can be better exerted.

Description

technical field [0001] The invention is a liver-targeting nanometer composition made of wheat prolamin and silibinin, a novel drug delivery system carrier material. It involves the fields of biomaterials, biomedical engineering and new drug research. Background technique [0002] Silybin (Silybin, SN) is an insoluble flavonoid compound extracted from the fruit of Silybum Marianum L., a plant of Compositae. Pharmacological experiments have proved that silibinin has obvious protective effect on liver damage caused by various liver poisons. Its target organ is the liver. After entering the body, it is mainly combined with plasma proteins, and exists in plasma, bile and urine in the form of bound silibinin (Shi Xiangguo, Zhong Dafang, Zhang Yifan, etc. RP-HPLC Determination of the concentration of silibinin in rat plasma [J]. Journal of Shenyang Pharmaceutical University, 2001, 18 (2): 113). It has good curative effect on acute and chronic hepatitis, liver cirrhosis and metab...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/357A61K47/42A61K9/19A61P1/16B82B3/00
Inventor 周亚伟
Owner 北大世佳科技开发有限公司
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