Nano-composition, preparing method and application thereof
A nano composition and nano technology, applied in the direction of nano structure manufacturing, nano technology, nano technology, etc., can solve the problems of undiscovered nano preparations, improve the encapsulation rate and drug loading, improve the therapeutic effect, and the preparation method is simple Effect
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Embodiment 1
[0044] Dissolve 100 mg of wheat prolamin and 15 mg of Poloxamer 188 in 12 ml of 70% ethanol solution, then add 18.8 mg of silibinin (SN), stir magnetically at 1500 rpm to dissolve, quickly add 28 ml of 1% Poloxamer 188 solution, continue stirring for 30 min, and rotate to evaporate Part of the ethanol is removed to obtain the colloidal solution of the nanometer composition. Add 400 mg of glucose and 200 mg of mannitol to the solution, fully dissolve, and lyophilize to obtain the nanocomposite lyophilized powder injection. After reconstitution with deionized water, the particle size was determined to be 203 nm, and the polydispersity index (PDI) was 0.217.
Embodiment 2
[0046] Dissolve 200mg of wheat prolamin and 30mg of Poloxamer188 in 15ml of 70% ethanol solution, then add 10mg of silibinin (SN), stir magnetically at 2500rpm to dissolve, quickly add 36ml of absolute ethanol, continue stirring for 20min, add dropwise 1% pentamer Dialdehyde solution 1.2ml, continue to stir and solidify for 8-12h, remove part of the ethanol by rotary evaporation, and obtain the nanocomposite colloidal solution. Add 200 mg of glucose and 200 mg of mannitol to the solution, fully dissolve, and lyophilize to obtain the nanocomposite lyophilized powder injection. After reconstitution with deionized water, the particle size was determined to be 280 nm, and the polydispersity index (PDI) was 0.112.
Embodiment 3
[0048] 120 mg of wheat prolamin and 16 mg of lecithin were dissolved in 6 ml of 70% ethanol solution, then 2.4 mg of silibinin (SN) was added, stirred with a magnetic force at a speed of 500 rpm to dissolve, and 24 ml of absolute ethanol was quickly added, continued to stir for 30 min, and added dropwise 2 % formaldehyde solution 2.4ml, continue to stir and solidify for 8-12h, and remove part of the ethanol by rotary evaporation to obtain a nanocomposite colloidal solution. Add 100 mg of glucose and 100 mg of mannitol to the solution, fully dissolve, and lyophilize to obtain the nanocomposite lyophilized powder injection. After reconstitution with deionized water, the measured particle size was 480 nm, and the polydispersity index (PDI) was 0.352.
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