135 results about "Diaminopyrimidine" patented technology

Compounds and methods for treating diseases mediated by a P2X3 and / or a P2X2 / 3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I):wherein D, X, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Compounds and methods for treating diseases mediated by a P2X3 and / or a P2X2 / 3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I):or a pharmaceutically acceptable salt, solvate or prodrug thereof,wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

The present invention relates to a method of making a compound of the formulawherein X1, X2 and R3—R4 are as defined herein. The method includes reacting a compound of the formulawith an amine of formula 3 (HNR3R4) in the presence of a Lewis Acid and a non-nucleophilic base. The 2,4-diamino pyrimidine moiety is a common component in a variety of biologically active drug-like molecules and pyrimidine derivatives have been found to be useful in the treatment of abnormal cell growth, such as cancer, in mammals.

Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and / or a P2X2 / 3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I):or a pharmaceutically acceptable salt thereof,wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

A method for preparing a compound of formula kor a salt or solvate thereof,wherein R1 is as defined herein,the method comprising treating a compound of formula jor a salt or solvate thereof,with ammonia, to form the compound of formula k.

Compounds and methods for treating diseases mediated by a P2X3 and / or a P2X2 / 3 receptor antagonist, the compounds being of formula (I):wherein D, X, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

A method for preparing a compound of formula Ithe method comprising treating a compound of formula dwith an iodination reagent, to form the compound of formula I, wherein R1, R2 and R3 are as defined herein.

The invention relates to an anti-hair loss and hair-strengthening nutrient solution and a preparation method thereof. The anti-hair loss and hair-strengthening nutrient solution is prepared from the following raw material components in parts by weight: 80 to 90 parts of compound plant extract, 5 to 9 parts of a hair conditioner, 3.5 to 10 parts of a humectant and 0.2 to 0.4 part of a thickening agent, wherein the composite plant extract is a mixture of water, a cacumen biotae extract, a radix polygoni multiflori extract, a ginger root extract, a folium mori extract, a black mulberry fruit extract, a sesame seed extract and a ginseng root extract, and the hair conditioner is a mixture of water, propylene glycol, glycerol, 1, 2-hexanediol, diaminopyrimidine oxide, polyglycerol-6 myristate, caprylic / capric triglyceride, pyrrolidinyl diaminopyrimidine oxide, lecithin, hydroxylated lecithin and cholesterin. The anti-hair loss and hair-strengthening nutrient solution has good effects of strengthening and toughening hair roots, preventing hair loss and promoting hair growth.

Compounds of formula (I):wherein R1 and R2 are as defined herein. Also disclosed are methods of making and using the subject compounds.

Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and / or a P2X2 / 3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I):or a pharmaceutically acceptable salt thereof,wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

The invention discloses an anti-loss hair-growth liquid and a preparation method thereof, a composition thereof comprises: a phase A comprising adenosine, nicotinamide, and water; a phase B comprisingdipotassium glycyrrhizinate and pyridoxine HCl; a phase C comprising an acrylate copolymer and water; a phase D comprising sodium hydroxide and water; a phase E comprising water, beeswax, hydroxyethyl behenamide propyl dimethyl ammonium chloride, behenyl alcohol, an avocado fruit extract, phenoxyethanol, ethylhexylglycerin, an apple fruit extract, a biota orientalis extract, a leaf extract of Ilex aquifolium, a mulberry leaf extract, and propylene glycol; a phase F comprising propylene glycol, the avocado extract, caffeine, beeswax, hydroxyethyl behenamide propyl dimethyl ammonium chloride, behenyl alcohol, phenoxyethanol, ethylhexyl glycerol, and water; a phase G comprising ethanol, biotin, pyrrole alkyl diaminopyrimidine oxide, and water; and a phase H comprising phenoxyethanol. The invention also provides a preparation method of the anti-loss hair-growth liquid. The anti-loss hair-growth liquid has the advantages of scientific ratio, safety, and non-toxic side effects, and can effectively promote hair growth.