Biological activity glass mesoporous microsphere and preparation method thereof

Abstract

The invention discloses a biological activity glass meso-porous microsphere and a preparation method thereof. The biological activity glass meso-porous microsphere comprises the following chemical compositions in percentage by weight: 16 to 36 percent of CaO, 4 percent of P2O5 and 60 to 80 percent of SiO2; the average grain diameter is between 2 and 5 [mu]m; the grains are sphere -shaped; the specific surface area of the grains is between 30.6m<2> / g and 89.7m<2> / g; and the meso-porous diameter is between 1.9 and 4.1nm. The method adopts the organic template method, comprising the following the steps that: a catalysts is added in deionized water, the mixed solution is added with tetraethoxysilane, triethyl phosphate and calcium nitrate tetrahydrate for hydrolysis reaction, the mixed solution is added with organic template polyethylene glycol and fully stirred to obtain sol, the sols is subject to aging to form wet gel, the wet gel is immersed in and washed by absolute ethyl alcohol and dried to obtain dry gel, and the dry gel is put in a crucible for heat treatment to obtain the finished products. The biological activity glass meso-porous microsphere has the advantages of higher biological activity and degradation property and good biological compatibility.

Description

technical field [0001] The invention relates to a biomedical microsphere material, in particular to a bioactive glass mesoporous microsphere and a preparation method thereof. Background technique [0002] Drug carrier is a kind of biomaterial product that gradually rises with the development of biomaterial science, clinical medicine and pharmacology. The drug enters the human body through the carrier, and the adsorption, encapsulation and bonding of the drug by the carrier makes the release site, speed and mode of the drug more selective and controllable, realizing the slow release and targeted delivery of the drug, so as to better play the role of drug therapy Effect. At present, most of the microspheres used for drug carriers are organic polymer materials, such as polylactic acid microspheres, polycaprolactone microspheres, chitosan microspheres, albumin microspheres, etc. These materials have the following properties: Defects: The degradation products of polylactic acid...

AI Technical Summary

Problems solved by technology

At present, most of the microspheres used for drug carriers are organic polymer materials, such as polylactic acid microspheres, polycaprolactone microspheres, chitosan microspheres, albumin microspheres, etc. These materials have the following properties: Defects: The degradation products of polylactic acid and the like are acidic, which is easy to cause cytotoxicity; the degradation rate is not easy to control, and it is easy to cause sudden release of drugs

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