Novel orthopaedics medicaments carrier system and preparation thereof

Abstract

The invention discloses a degradable orthopedics drug carrier system with osteo inductivity and a preparation method thereof. The drug carrier system essentially consists of the carrier material which is biological activity glass setting solid and the carried therapeutic drug. And the carrier material is the solid body carrier material with certain strength which is obtained through the fast curing after the reaction of highly reactive boron-containing biological activity glass and cured buffer liquid after the reaction. The carrier material can carry various drugs without thermal stability restriction, such as antibiotics, bone growth factors, antituberculosis drugs, antineoplastic drugs, which are used for the treatment of orthopedics diseases, thus composing the integrated drug carriersystem. The drug carrier system can degrade automatically under the function of human tissue fluid in a human body with a porous structure left during the degradation which provides diffusion channels for the sustainable releasing of the drugs, thus achieving the effect that the drugs are chronically and uniformly released. The drug carrier system has good biocompatibility, biological activity and osteo inductivity and can be applied to the treatment of various diseases of orthopedics.

Description

technical field [0001] The invention belongs to the field of biomaterials, and relates to an osteoinductive and fully degradable orthopedic drug carrier system and a preparation method thereof. Background technique [0002] The implantable drug sustained-release system is to load the drug into a certain carrier, and then directly implant the drug carrier into the infected area. Through the special structure of the carrier (usually there are two structural forms: integral type and reservoir type), continuous and uniform A method of releasing a drug over a long period of time to kill a target bacterium. This method can avoid the shortcomings of multiple administrations and large fluctuations in drug release rate, so that the drug can reach and maintain a high concentration at the target site, while the non-drug receiving site maintains a low systemic blood drug concentration, thus eliminating the traditional method. During the treatment, the systemic drug causes the disadvant...

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Problems solved by technology

[0003] In the 1970s, Klemm invented polymethyl methacrylate (PMMA) bone cement containing gentamicin and achieved certain curative effect in the treatment of osteomyelitis. However, the bonding of PMMA bone cement is an exothermic process and the temperature is high, so it can only be used for high temperature resistance. limited doses of antibiotics

Calcium phosphate bone cement is a kind of inorganic material mainly composed of various calcium phosphate salt powders. It has good biocompatibility, but this type of material is not osteoinductive, and the degradation rate is slow and cannot be fast. replaced by new bone

In 2005, Chinese patent CN1686557A disclosed the method of using calcium sulfate as a drug carrier. This type of material has good biocompatibility, and has a faster degradation rate than calcium phosphate materials, and does not require secondary surgery to remove the carrier, but Not osteoconductive and osteoinductive, the implant site is still defective, still a weak part of the bone

In 2001, U.S. Patent USP6197342 disclosed a preparation method of a drug sustained-release system using bioactive glass ceramics as a matrix. This type of material has good osteoinductivity, but it mainly uses silicon oxide as the main body of the network, and it degrades slowly in vivo, and It cannot be completely degraded, and the preparation process is more complicated than bone cement

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