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Wound dressing capable of insulating sea water and method of preparing the same

A wound surface and sodium alginate technology, which is applied in medical science, bandages, absorbent pads, etc., can solve the problems of poor mechanical strength of dressings, achieve good expansion rate and air permeability, and better waterproof effect

Inactive Publication Date: 2008-08-27
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The dressing made of pure chitosan has poor mechanical strength, and the wound healing effect of pure alginic acid is not as good as that of chitosan. Chinese patent CN02111437.4 discloses a dressing composed of chitosan, collagen and calcium alginate. Sponge biological dressing and its preparation process
[0007] At present, there is no literature report on biological dressings that not only have strong hemostatic and anti-infective properties, but also can effectively block the erosion of seawater on the wound surface.

Method used

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  • Wound dressing capable of insulating sea water and method of preparing the same
  • Wound dressing capable of insulating sea water and method of preparing the same
  • Wound dressing capable of insulating sea water and method of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The preparation of embodiment 1 wound dressing

[0046] The first step: preparation of chitosan solution

[0047] Take fresh shrimp shells, remove the head, feet and tail, wash them with water, soak them in 5% HCl and 10% NaOH respectively to remove calcium and protein, wash until neutral, dry, and grind to obtain powdered chitin. Take powdered chitin and deacetylate it in 50% NaOH solution above 100°C for more than 24 hours, then neutralize, wash with water for injection until neutral, dehydrate with alcohol, and finally vacuum dry to obtain chitosan with a deacetylation degree of 90%. . The chitosan was dissolved in 1% (V / V) acetic acid to make the final chitosan solution concentration 2% (W / V).

[0048] The second step: preparation of sodium alginate solution

[0049] Dissolve 2g of sodium alginate in 100ml of deionized water to make a 2% (m / v) solution, then filter through 100-mesh silk cloth, slowly add 2% CaCl dropwise to the infusion tube under magnetic stirri...

Embodiment 2

[0056] The preparation of embodiment 2 wound dressings

[0057] The first step is the same as example 1;

[0058] The second step: preparation of sodium alginate solution

[0059] Dissolve 2g of sodium alginate in 100ml of deionized water to make a 1-3% (m / v) solution, then filter through 100-mesh silk cloth, slowly add 2% CaCl dropwise to the infusion tube under magnetic stirring 2 solution, after the two are mixed evenly, continue to stir for 1h to make sodium alginate and CaCl 2 The mass ratio is controlled at 20:1.

[0060] The third step: mixing of sodium alginate solution and chitosan solution

[0061] The uniformly stirred sodium alginate solution was slowly added dropwise with 2% chitosan solution through an infusion tube under magnetic stirring, so that the mass ratio of sodium alginate and chitosan was controlled at 1:1.

[0062] The fourth and fifth steps are the same as Example 1.

Embodiment 3

[0063] The preparation of embodiment 3 wound dressings

[0064] The first step is the same as example 1;

[0065] The second step is the same as example 2;

[0066] The third step is the mixing of sodium alginate solution and chitosan solution

[0067] The uniformly stirred sodium alginate solution was slowly added dropwise with 2% chitosan solution through an infusion tube under magnetic stirring, so that the mass ratio of sodium alginate and chitosan was controlled at 5:1.

[0068] The fourth and fifth steps are the same as Example 1.

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Abstract

The invention relates the medical biomaterial technology field. The existing clinical hemostasis dressing is only used for stopping blood, while the new biological dressing is only used for cleaning and healing superficial wounds and lacks a specific direction for treating posttraumatic wound, in particular, sea battle injury. The aim of the invention is to provide a method for preparing a hemostasis dressing with good volume expansibility, permeability, as well as obvious direction to deal with high-permeability seawater. The method for preparing the hemostasis dressing uses sodium alginate mixed by chitosan and various Na<+> / Ca<2+> as the basic material to form a hemostasis sponge with good mechanical strength after being cooled and dried, and prepares asymmetric seawater hemostasis dressing with porous layer and compact layer by using polyvinyl alcohol as the surface coating material. The dressing shows high expansibility and good permeability according to the results of volume expansibility, permeability and sem observation, has rich porous layer and compact water-resistant layer in microstructure, and is applied for stooping blood and healing wounds in high-permeability seawater environment.

Description

technical field [0001] The invention relates to the technical field of medical biomaterials, in particular to a wound dressing capable of isolating seawater and a preparation method thereof. Background technique [0002] With the application of precision-guided weapons and large-destructive conventional weapons in modern warfare, the number of direct deaths has been relatively significantly reduced. The relative increase in open wounds in both military and civilian populations has remained relatively unabated. Therefore, first aid for wounds in wartime, especially for open wounds, is more significant. The hemostatic bandaging as one of the main contents of first aid, the current method and equipment are just to pressurize the bandage with a clean dressing to achieve the hemostatic effect under pressure, the function is simple, and the effect is limited. If it can meet the characteristics of batch occurrence of war wounds, many open wounds, large amount of bleeding, complic...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/24A61L15/42
Inventor 张伟魏长征侯春林顾其胜
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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