Application of forsythiaside in the preparation of medicament for treating or preventing acute and chronic liver damnification and liver fibrosis

A technology for acute liver injury and chronic liver injury, applied in drug delivery, drug combination, digestive system, etc., can solve the problems of high cost, easy recurrence, and unsatisfactory treatment effect.

Inactive Publication Date: 2008-03-05
SHANDONG LUYE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Interferon is the drug of choice, but there are disadvantages such as large dosage, high cost, high toxicity and side effects, low effective rate, and easy recurrence after drug withdrawal.
The therapeutic effect of traditional Chinese medicine is also unsatisfactory. The curative effect of the medicine is inaccurate, the treatment period is long, and the cost is high. Long-term use will cause side effects and damage the health of the body.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0014] Preparation Example 1 Preparation of Forsythiaside

[0015] Take 5Kg of Forsythia fruit, crush it until it can pass through a No. 3 sieve, add 50% ethanol to extract twice at room temperature, first use 20 times the amount of ethanol solution, soak for 4 hours, add 10 times the amount of ethanol solution for the second time, and soak for 3 hours at room temperature Hour. Combine the two extracts, adjust the pH to about 4, dealcoholize under reduced pressure at low temperature, put on the NK-9 macroporous resin column, wash 3 column volumes with water, then wash 5 column volumes with 10% ethanol aqueous solution, and then use 40% ethanol was eluted for 5 column volumes. Collect the 40% alcohol eluted effluent, and dry it under reduced pressure at 70°C to obtain 21.2 g of forsythiaside with a content of 90.4%.

preparation example 2

[0016] Preparation Example 2 Preparation of Forsythiaside

[0017] Take 1Kg of forsythia leaves, crush them, add 50% ethanol to extract twice at room temperature, soak for 4 hours with 20 times the amount of ethanol solution for the first time, and soak for 3 hours at room temperature with 10 times the amount of ethanol solution for the second time. Combine the two extracts, adjust the pH to about 4, dealcoholize under reduced pressure at low temperature, put on a polyamide resin column, wash 3 column volumes with water, then wash 5 column volumes with 25% ethanol aqueous solution, and then wash with 40% ethanol Remove 5 column volumes. Collect 40% eluent eluting with alcohol, concentrate under reduced pressure at 70°C, place at low temperature for two days, centrifuge, and dry the precipitate to obtain 36.8 g of forsythiaside with a content of 95.1%.

preparation example 3

[0018] Preparation Example 3 Preparation of Forsythiaside Freeze-Dried Powder for Injection

[0019] Take 20.0g of forsythiaside, add 2000ml of water for injection to dissolve, add 8g of mannitol, stir to dissolve, and ultra-filter to obtain a pyrogen-free clear liquid, pour it into a 10ml vial, 2ml / bottle, press lyophilized powder Freeze-dried by needle process to make freeze-dried powder injections containing 20.0 mg of forsythiaside each.

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PUM

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Abstract

The present invention is the application of forsythia ester glycoside in preparing medicine for preventing and treating acute and chronic liver injury and liver fibrosis. The dosage of the medicine is 25-800 mg for injection and 50-1500 mg for orally taken preparations. The medicine with forsythia ester glycoside as effective component may be prepared into injection, tablet, capsule, pill or other forms, preferably freeze dried powder for injection and capsule.

Description

technical field [0001] The invention relates to a drug for treating liver diseases, in particular to the application of forsythiaside in the prevention or treatment of acute and chronic liver injury and liver fibrosis caused by viruses, chemical substances and drugs. Background technique [0002] Hepatitis means inflammation of the liver. Infection by many pathogenic microorganisms such as viruses, bacteria, fungi, rickettsia, spirochetes, and some protozoa and parasites may cause liver inflammation; Ethanol, etc.) and certain drugs (such as ramifen, indomethacin, chlorpromazine, etc.) poisoning can cause toxic hepatitis. The hepatitis caused by drug poisoning is called drug-induced hepatitis; the hepatitis caused by chemical substances is called chemical hepatitis; the hepatitis caused by viruses is called viral hepatitis, which includes various types of hepatitis virus, herpes virus, Epstein-Barr virus, cytomegalovirus , varicella virus, enterovirus and adenovirus. [0...

Claims

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Application Information

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IPC IPC(8): A61K31/7028A61K9/00A61P1/16
Inventor 蒋王林曲桂武田京伟
Owner SHANDONG LUYE PHARMA CO LTD
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