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Partial suspended eye drop containing ciprofloxacin and dexamethasone

A technology of dexamethasone and ciprofloxacin, which is applied in the field of eye preparations and suspension eye drops of ciprofloxacin and dexamethasone to achieve the effects of reducing irritation, improving drug efficacy and excellent effect

Inactive Publication Date: 2008-02-27
长治市三宝生化药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The fourth edition of Pharmaceutics published by People's Health Publishing House points out that the suitable viscosity of eye drops is 4.0-5.0cPa·s, and hydroxyethyl cellulose with a concentration of 0.1-0.5% obviously cannot achieve this purpose.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0151] Ciprofloxacin hydrochloride monohydrate 30.0g (calculated as ciprofloxacin)

[0152] Dexamethasone 10.0g

[0153] Sodium chloride 43g

[0154] Acetic acid 4g

[0155] Sodium acetate 3.9g

[0156] Hydroxypropyl Methyl Cellulose 200g

[0157] Polysorbate 80 10g

[0158] Sodium Calcium EDTA 1g

[0159] Boric acid 60g

[0160] Benzalkonium Bromide 1g

[0161] Water for injection 10000mL

[0162]

[0163] Makes 1000 bottles

[0164] 1). Take the ratio of ciprofloxacin hydrochloride monohydrate, sodium chloride, acetic acid, sodium acetate, calcium sodium edetate, boric acid, benzalkonium bromide and mix together, dissolve with 3500mL sterile pure water .

[0165] 2). Take a proportioned amount of hydroxypropyl methylcellulose, add it to 4000mL sterile pure water, and heat to dissolve.

[0166] 3). Take the dexamethasone and polysorbate 80 kun that have been sterilized (2 hours at 180°) in proportion, and add 800 mL of sterile...

Embodiment 2

[0170] Ciprofloxacin hydrochloride monohydrate 30.0g (calculated as ciprofloxacin)

[0171] Dexamethasone 10.0g

[0172] Sodium chloride 43g

[0173] Acetic acid 2g

[0174] Sodium acetate 1.9g

[0175] Hydroxypropyl Methyl Cellulose 200g

[0176] Polysorbate 80 5g

[0177] Sodium Calcium EDTA 1g

[0178] Boric acid 60g

[0179] Benzalkonium Bromide 1g

[0180] Water for injection 10000mL

[0181]

[0182] Makes 1000 bottles

[0183] The preparation method is the same as in Example 1.

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Abstract

The invention discloses a suspension eye drops with ciprofloxacin and anaflogistico to give drug locally, which comprises the following parts: anaflogistico, ciprofloxacin, sodium chloride, hydroxypropylmethylcellulose, polysorbate 80 and acetic acid / sodium acetate buffer, wherein the density of hydroxypropylmethylcellulose is 1. 0-5. 0%. The invention has fitful viscosity to lengthen the retaining time of the drug and improve the biological utility of the drug, which reduces the stimulation for eyes effectively and improves the survivability for the patient.

Description

technical field [0001] The present invention relates to a locally administrable ophthalmic preparation, in particular to a locally administrable suspension eye drop containing ciprofloxacin and dexamethasone. Specifically, the present invention uses an additive combination with a suitable viscosity to design an ophthalmic formulation suitable for ciprofloxacin and dexamethasone, so as to improve the bioavailability of the eye drops and reduce irritation. Background technique [0002] EP2065846A1 discloses topically administrable ophthalmic and otic antibiotic / steroid combination products, and its Examples 1-3 describe containing certain ophthalmic suspension formulation of the drug. Embodiment 1 is the preparation of clomethasone copper and lomefloxacin, containing nonionic reinforcing agent (glycerin); sodium chloride); embodiment 3 is the preparation of ciprofloxacin and dexamethasone, containing non-ionic reinforcing agent (mannitol). [0003] US5540930 and US5747061 d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61K9/10A61K47/38A61P27/02A61K31/496
Inventor 李湘益
Owner 长治市三宝生化药业有限公司
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