Vinorelbine solid lipid nano granule, freeze drying formulated product and method of preparing the same
A solid lipid nanotechnology, vinorelbine technology, applied in the field of medicine, can solve the problems of high operating temperature, strong blood vessel irritation, poor patient compliance, etc., to avoid instability, avoid drug degradation, and reduce encapsulation efficiency Effect
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Embodiment 1
[0064]The vinorelbine solid lipid nanoparticles provided by the present invention are composed of vinorelbine, lipid materials, phospholipids, and oleic acid: vinorelbine 14mg
[0065] Glyceryl monostearate 200mg
[0066] Lecithin 90mg
[0067] Oleic acid 14mg
[0068] Preparation method: (1) melt the lipid material glyceryl monostearate in the prescribed amount in a water bath at 60°C; (2) dissolve the prescribed amount of phospholipids, oleic acid, and vinorelbine in ethanol, and then add dropwise (3) After completely removing ethanol under vacuum and decompression conditions, quickly place it in liquid nitrogen to cool; (4) Take it out after being completely frozen, grind it with a mortar and disperse it in an appropriate amount of 1%F 68 In the aqueous phase, the pH of the aqueous phase is 4; (5) mash under the tissue masher, 3000rpm, 6000rpm, each 15min, to prepare the primary suspension; (6) transfer the prepared primary suspension to the high-pressu...
Embodiment 2
[0071] The vinorelbine solid lipid nanoparticles provided by the present invention are composed of vinorelbine, lipid materials, phospholipids, and oleic acid: vinorelbine 42mg
[0072] Glyceryl monostearate 200mg
[0073] Lecithin 90mg
[0074] Oleic acid 14mg
[0075] Preparation method: (1) melt the lipid material glyceryl monostearate in the prescribed amount in a water bath at 60°C; (2) dissolve the prescribed amount of phospholipids, oleic acid, and vinorelbine in ethanol, and then add dropwise (3) After completely removing ethanol under vacuum and decompression conditions, quickly place it in liquid nitrogen to cool; (4) Take it out after being completely frozen, grind it with a mortar, and disperse it in an appropriate amount of 1%F 68 In the aqueous phase, the pH of the aqueous phase is 3.7; (5) mash under the tissue masher, 3000rpm, 6000rpm, each for 15min, to prepare the primary suspension; (6) transfer the prepared primary suspension to a high-...
Embodiment 3
[0078] The vinorelbine solid lipid nanoparticles provided by the present invention are composed of vinorelbine, lipid materials, phospholipids, and oleic acid: vinorelbine 100mg
[0079] Glyceryl monostearate 150mg
[0080] Lecithin 140mg
[0081] Oleic acid 10mg
[0082] Preparation method: (1) melt the lipid material glyceryl monostearate in the prescribed amount in a water bath at 60°C; (2) dissolve the prescribed amount of phospholipids, oleic acid, and vinorelbine in ethanol, and then add dropwise (3) After completely removing ethanol under vacuum and decompression conditions, quickly place it in liquid nitrogen to cool; (4) Take it out after being completely frozen, grind it with a mortar, and disperse it in an appropriate amount of 1%F 68 In the aqueous phase, the pH of the aqueous phase is 4; (5) mash under the tissue masher, 3000rpm, 6000rpm, each 15min, to prepare the primary suspension; (6) transfer the prepared primary suspension to the high-pr...
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