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Method of preparing smectite suspension agent

A montmorillonite gel agent and the technology of montmorillonite, which are applied in the field of medicine, can solve the problems of high viscosity, difficult to divide the dose accurately, poor taste, increase production cost, etc., and achieve fine particle size, reduce production cost and good effect. Effect

Inactive Publication Date: 2008-02-27
JINAN KANGZHONG PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high viscosity, it is not easy to accurately divide the dose; the taste is poor; and the production cost is increased

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Montmorillonite suspension formula:

[0022] Montmorillonite 300g Glucose 74.9g Sodium Saccharin 0.7g

[0023] Vanillin 0.4g Sodium Benzoate 9 Deionized Water 15000g

[0024] Preparation:

[0025] (1) Weigh the raw materials and auxiliary materials of the formula formula.

[0026] (2) Add montmorillonite into deionized water and stir evenly, then add sucrose and sodium benzoate, and stir evenly.

[0027] (3) Process the uniformly stirred mixed solution with a colloid mill to form a uniform suspension with a fineness of montmorillonite particles less than 10 μm.

[0028] (4) Suspension through cobalt 60 After irradiation sterilization, it can be obtained by dispensing.

Embodiment 2

[0030] Montmorillonite suspension formula:

[0031] Montmorillonite 200g, sucrose 150g, ethylparaben 0.5g,

[0032] Propylparaben 0.5g, deionized water 13000g.

[0033] Preparation:

[0034] (1) Weigh the raw materials and auxiliary materials of the formula formula.

[0035] (2) First add montmorillonite into deionized water and stir evenly, then add sucrose, glucose, ethylparaben and propylparaben and stir evenly.

[0036] (3) The homogeneously stirred mixed solution is then ultrasonically treated to form a uniform suspension with a particle size of montmorillonite less than 10 μm.

[0037] (4) After the suspension is boiled for 15 minutes to sterilize, it can be packaged separately.

Embodiment 3

[0039] Montmorillonite suspension formula:

[0040] Montmorillonite 250g, Aspartame 0.7g, Vanillin 0.3g,

[0041] Ethylparaben 5g, sodium benzoate 45g, deionized water 17000g.

[0042] Preparation:

[0043] (1) Weigh the raw materials and auxiliary materials of the formula formula.

[0044] (2) First add montmorillonite into deionized water and stir evenly, then add sucrose, glucose, ethylparaben and sodium benzoate and stir evenly.

[0045] (3) Process the uniformly stirred mixed solution with a homogenizer to form a uniform suspension with a fineness of montmorillonite particles less than 10 μm.

[0046] (4) The suspension was heated at 70°C for 1 hour, then placed at room temperature for 24 hours, and then heated at 70°C for 1 hour, and the heating and placing operations were continuously sterilized for 3-5 times.

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PUM

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Abstract

The invention provides a montmorillonite mixing-floating agent for treating loose bowel movement and making method, which comprises the following steps: (1) drawing formulating amount montmorillonite, correcting agent, preservative agent, anddeionized water; (2) adding the montmorillonite into the anddeionized watert to stir uniformly to add the correcting agent and the preservative agent to stir uniformly; (3) producing the mixing liquid to form the uniform mixing-floating agent with grain fineness of the montmorillonite less than10mu m through colloidal mill that can be placed with homogenizer or ultrasonic machine; (4) sterilizing to split charging to get the mixing-floating agent. The invention has merits of fitting viscosity for splitting dose accurately and reducing production cost without assisting-floating agent, which makes the montmorillonite disperse thoroughly through the colloidal mill with finer grains that can be distributed in body's digestive tract rapidly after taking and with better effect.

Description

field of invention [0001] The invention relates to a preparation method of a montmorillonite suspension, which belongs to the technical field of medicines. Background technique [0002] Montmorillonite is a drug that has been proved to be effective in treating diarrhea with few toxic and side effects. The montmorillonite preparations developed since the 1990s include powders, granules, dispersible tablets, gels, and suspensions. The above-mentioned dosage forms are due to the rapid drug effect of the suspension; easy to divide doses; suitable for infants and elderly patients; convenient to take; and are very popular with patients. [0003] Existing montmorillonite suspension preparation method is, in order to improve the stability of suspension, increase the viscosity of dispersion medium to reduce the settling velocity of montmorillonite particle, add glycerin, gum arabic, peach gum, sodium alginate, Agar cellulose and other suspending agents. Due to the high viscosity, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K33/06A61K33/00A61P1/12
Inventor 李诗标张为胜许翠萍张晶许竹梅
Owner JINAN KANGZHONG PHARMA TECH DEV
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