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Target medicine used for treating bacteriosis, and its preparing method

A bacterial disease and targeted technology, applied in the direction of antibacterial drugs, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of waste, damage, drug residues, etc., achieve improved drug efficacy, good curative effect, and avoid waste Effect

Inactive Publication Date: 2010-08-25
HUNAN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

1) Long-term large-scale medication, the drug deposits in body tissues, especially adipose tissue, forming drug residues, threatening human health
2) A large number of drugs are metabolized, which not only causes a lot of waste, but also causes damage to the metabolic organs of the drug during the drug metabolism process; the cost and price of epidemic prevention and control are too high
There is no substantive research progress on how to improve the bacteriostatic and bactericidal efficiency of existing antibiotics, and how to effectively eliminate bacterial resistance to existing antibiotics, and it can be expected that the existing research results will only bring about "dao high". One foot, the devil is one foot tall" Consequences

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Select diseased pigs with symptoms of yellow and white scorching from pig farms, aseptically collect the mesenteric lymph nodes of the diseased pigs, inoculate them on MacConkey agar with the method of dividing lines, place them in a 37°C incubator for 24 hours, and then pick out the MacConkey agar The upper red colony was inoculated into LB liquid medium and cultured in a 37°C incubator for 24 hours. After that, E. coli was identified by biochemical tests for identifying E. coli, and then the identified E. coli was used as a strain to culture in large quantities with LB liquid medium. , and then inactivate the culture with formaldehyde. After testing, after complete inactivation, use the inactivation solution as the water phase, and use 7 # White oil is the oil phase, emulsified to make Escherichia coli oil emulsion inactivated vaccine, and then use Escherichia coli oil emulsion inactivated vaccine to immunize rabbits, collect rabbit blood every 7 days, and use indirec...

Embodiment 2

[0034] Animal disease model treatment test:

[0035] Dilute the precipitate of the conjugate of Example 1 (that is, the targeted drug of the present invention, the same below) with physiological saline to the same volume as the gentamicin sulfate solution before binding, and set aside. Purchase 60 healthy mice with a size of about 20g, randomly divide them into 6 groups, and use 5LD 50 The amount of E. coli per mouse was inoculated into all mice, and the treatment was started when the mice showed symptoms. The first group was used as a blank control; the second group was treated with anti-E. coli serum antibodies;

[0036] The third group was treated with gentamicin sulfate according to the usage and dosage of the instructions; the fourth group was treated with the conjugate with the same dose of gentamicin sulfate; the fifth group was treated with the same conjugate equivalent to 1 / 10 gentamicin sulfate dose Combined treatment; the sixth group was treated with the same conju...

Embodiment 3

[0038] Clinical Treatment Trials:

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PUM

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Abstract

A target medicine for treating bacterial disease features that its active component is a conjugate of the antibacterial serum antibody and antibiotic, and the target medicine can move toward bacteria, resulting in high effect. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a targeted drug for treating bacterial diseases and a preparation method thereof. Background technique [0002] At present, when conventional antibiotics are used to treat bacterial diseases, regardless of the route of administration, the drug will be evenly distributed in the animal's body tissues and body fluids (except for a few parts such as the brain) after entering the animal body. The concentration of the drug is called Blood concentration. As the liver metabolizes the drug, the blood drug concentration becomes lower and lower. Bacteria are not evenly distributed in animals, but mainly in their target organs. Even in the target organ, the combination of drug and bacteria depends entirely on random collisions. Therefore, in order to ensure the curative effect, it is necessary to maintain a high drug concentration in the tissue where the bacteria are located for a long time. Therefore, when antibiotics are used to treat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/48A61K45/00A61K31/7036A61P31/04A61K39/395A61K47/68
Inventor 董伟孙志良陈小军
Owner HUNAN AGRICULTURAL UNIV
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