Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Isoglycyrrhiza acid magnesium externally-applied preparation, its making method and usage

A technology of magnesium isoglycyrrhizinate and magnesium glycyrrhizinate permeating the skin is applied in the field of external preparations of magnesium isoglycyrrhizinate, which can solve the problems of dry and cracked skin, incompatibility and the like, and achieve the effects of improving compliance and convenient use.

Active Publication Date: 2009-09-30
CHIA TAI TIANQING PHARMA GRP CO LTD
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the gel is easy to cause dry and cracked skin, it is not suitable for topical administration of hypertrophic lichenification such as psoriasis. We have studied other external preparations suitable for the treatment of psoriasis and dermatitis, such as ointment, cream, transdermal patch, Film agent, film coating agent and paint, have overcome above-mentioned defective, thus completed the present invention

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Embodiment 1: water-soluble base type ointment

[0073] Prescription (200g):

[0074] Magnesium Isoglycyrrhizinate 2g

[0075] Macrogol 4000 60g

[0076] Macrogol 400 90g

[0077] Water-soluble Azone 4g

[0078] Ethylparaben 0.2g

[0079] 10% ammonia water appropriate amount

[0080] Glycerin 10g

[0081] Distilled water up to 200g

[0082] Preparation method: 1. Dissolve magnesium isoglycyrrhizinate and an appropriate amount of 10% ammonia water in distilled water, dissolve ethylparaben in glycerin, mix well, add water-soluble azone, and stir well.

[0083] 2. Mix polyethylene glycol 4000 and polyethylene glycol 400, heat to about 70°C on a water bath, and stir well.

[0084] 3. Add (1) into (2), add water to 200g, stir until condensed, and you get it.

Embodiment 2

[0085] Embodiment 2: water-in-oil cream

[0086] Prescription (200g):

[0087] Magnesium Isoglycyrrhizinate 2g

[0088] Span 80 4g

[0089] Chlorocresol 0.4g

[0090] Beeswax 15g

[0091] Liquid paraffin 50g

[0092] White Vaseline 10g

[0093] Glyceryl monostearate 30g

[0094] 5% sodium hydroxide appropriate amount

[0095] Distilled water 88g

[0096] Preparation method: 1. Put beeswax, glyceryl monostearate, liquid paraffin, white vaseline and Span 80 into the oil phase, put it in an evaporating dish, and heat it to about 80°C on a water bath.

[0097] 2. Dissolve magnesium isoglycyrrhizinate plus an appropriate amount of 5% sodium hydroxide in distilled water, add chlorocresol, heat to about 80°C on a water bath, stir to dissolve, and form a water phase.

[0098] 3. Slowly add the water phase into the oil phase at about 80°C, and keep stirring on a water bath until it becomes a milky white semi-solid, and then stir at room temperature until it is nearly condensed...

Embodiment 3

[0099] Embodiment 3: Filled closed type magnesium isoglycyrrhizinate transdermal patch

[0100] The patch described in this embodiment is composed of a backing layer, a drug storage layer, a release-controlling film, an adhesive layer and a protective layer. The materials used for each layer are as follows:

[0101] Backing layer: aluminum foil / polyethylene composite film

[0102] Protective layer: polyester film

[0103] Controlled Release Membrane: Ethylene-vinyl acetate copolymer membrane

[0104] Adhesive layer: silicone pressure sensitive adhesive

[0105] Drug storage layer (200g):

[0106] Magnesium Isoglycyrrhizinate 20g

[0107] Carbomer 4g

[0108] Appropriate amount of triethanolamine

[0109] Glycerin 20g

[0110] Azone 4g

[0111] 5% sodium hydroxide appropriate amount

[0112] Distilled water up to 200g

[0113] Preparation method:

[0114] 1. Prepare the drug storage layer:

[0115] (1) Slowly add carbomer to 50% distilled water under stirring to make...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
weightaaaaaaaaaa
Login to View More

Abstract

The external dosage form containing magnesium isoglycyrrhizinate includes ointment, cream, transdermal patch, film, film coating and paint, and also relates to its preparation method and application in medicine. The external dosage form of the present invention can effectively treat psoriasis, chronic eczema dermatitis, contact dermatitis and other allergic skin diseases.

Description

technical field [0001] The invention relates to an external preparation of magnesium isoglycyrrhizinate, including ointment, cream, transdermal patch, film, film coating and paint, as well as its preparation method and application in medicine. technical background [0002] Glycyrrhizic acid has pharmacological effects such as anti-inflammation, anti-allergy, immune regulation, anti-biological oxidation and inhibition of mutation. Clinically, diammonium glycyrrhizinate has been administered intravenously to treat psoriasis and dermatitis, such as eczema, and has a good effect. Oral preparations of glycyrrhizic acid, such as compound glycyrrhizin tablets (trade name Meineng), are also used clinically to treat skin diseases such as psoriasis and eczema, but these glycyrrhizic acid preparations have certain side effects, such as water and sodium retention, etc. patient medication compliance. At present, there is no product of topical application of glycyrrhizic acid on the mar...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K9/06A61K9/70A61P17/00A61P37/08
Inventor 程艳菊张来芳张喜全
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com