Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Curcumin emulsion and its preparation process

A technology of curcumin emulsion and curcumin, which is applied in the direction of medical formula, emulsion delivery, medical preparations containing active ingredients, etc., can solve the problems that curcumin is not suitable for development into injections, etc., so as to improve the quality of life and reduce side effects , increase the effect of immune function

Inactive Publication Date: 2009-05-13
SHANDONG LUYE PHARMA CO LTD
View PDF6 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Described in [Chinese herbal medicine, 2002,8 (25): 585-586] with DMSO solubilization, dissolves with Hanks solution, the valid period of the curcumin injection that makes is 0.2 year, and draws that it is not suitable to develop curcumin Injection conclusion

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Curcumin emulsion and its preparation process
  • Curcumin emulsion and its preparation process
  • Curcumin emulsion and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0020] Preparation Example 1: Preparation of Curcumin Oral Emulsion

[0021] Dissolve 50 mg of curcumin, 2.0 g of soybean lecithin, and 0.5 g of cholesterol in ethanol and add them to 10 g of refined soybean oil, mix until clear, and remove the alcohol by rotary evaporation or nitrogen evaporation to obtain 5 mg / g curcumin, soybean An oil solution of 200mg / g phospholipids and 50mg / g cholesterol.

[0022] Disperse 1.0 g of poloxamer into an appropriate amount of water for injection, slowly add curcumin-containing phospholipid and cholesterol oil solution dropwise into the water dispersion system under high-speed stirring conditions to make a coarse emulsion, and dilute with water to 100ml. After the emulsification is completed, sterilize at 100°C for 30 minutes, and divide into packages to obtain an emulsion containing curcumin 0.5 mg / ml.

preparation example 2

[0023] Preparation Example 2: Preparation of curcumin injection emulsion

[0024] Dissolve 500 mg of curcumin and 500 mg of oleic acid in ethanol and add it to 10 g of refined soybean oil, mix until clear, and remove the alcohol by rotary evaporation or nitrogen evaporation to obtain curcumin 50 mg / g and 50 mg / g oleic acid soybean oil solution.

[0025] Add 3.0 g of poloxamer and 2.25 g of glycerin to an appropriate amount of water for injection, and slowly add the oil solution containing curcumin and oleic acid dropwise into the above-mentioned water dispersion system under high-speed stirring conditions to make a coarse emulsion. Dilute to 100ml with water for injection. The obtained coarse emulsion was further emulsified by a milk homogenizer under the condition of a pressure of 60Mpa. After the emulsification was completed, it was sterilized at 100° C. for 30 minutes, and then packed to obtain curcumin emulsion for injection 5 mg / ml.

preparation example 3

[0026] Preparation Example 3: Preparation of Curcumin Oral Emulsion

[0027] Dissolve 5000 mg of curcumin and 3.0 g of egg yolk phospholipids in ethanol and add them to 40 g of corn oil, mix until clear, and remove the alcohol by rotary evaporation to obtain a corn oil solution containing 125 mg / g of curcumin and 75 mg / g of egg yolk phospholipids.

[0028] Under the condition of high-speed stirring, slowly drop the oil solution of phospholipid containing curcumin into the aqueous solution of an appropriate amount of 1% hydroxypropyl β-cyclodextrin to make a coarse emulsion, add pure water to 100ml, and divide it to obtain curcumin Emulsion 50mg / ml.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a curcumin oral emulsion and injection, wherein the emulsion comprises curcumin, oil, emulsifying agent and water, the injection also contains isotonic agent. The invention also discloses the process for preparing the emulsion and its use in preparing medicaments for treating or preventing tumor, resisting tumor transfer, enhancing curative effects of chemotherapy drugs, reducing side effects of chemotherapy and improving immunity functions for tumor patients.

Description

field of invention [0001] The present invention relates to curcumin emulsion and its preparation method and application. Background technique [0002] Curcumin in a broad sense is usually called curcumin, which is derived from commonly used traditional Chinese medicines of the genus Curcuma long L., Curcuma wenyujin Y.H.Chen et C.Ling, Curcuma kwangsiensis S.G.Leeet C.F.Liang (Curcuma phaeocaulis Val.) The active ingredients isolated from the dry tuber root, including curcumin (curcumin), demethoxycurcumin (demethoxycurcumin) and bis-demethoxycurcumin (bis-demethoxycurcumin) [Liu Shuxing, Hu Xiaojun, Journal of Shaanxi University of Science and Technology: Natural Science Edition, 2003]. Unless otherwise specified below, curcumin refers to curcumin in a broad sense, and their structural formulas are as follows: [0003] [0004] I Curcumin R 1 =R 2 =CH 3 o [0005] II demethoxycurcumin Demethoxycurcumin R 1 = H, R 2 =CH 3 o [0006] III bisdemethoxycurcumin Bisd...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/122A61K9/107A61P35/00
Inventor 王振华张雪梅马福禄苟海涛何杰
Owner SHANDONG LUYE PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com