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Donkey-hide gelatin oral preparation and its making method

An oral preparation and Ejiao technology, applied in the field of Ejiao oral preparations, can solve the problems of single dosage form, unable to meet clinical needs, large dosage, etc., and achieve the effects of facilitating clinical use, overcoming taste problems, and improving controllability

Active Publication Date: 2009-05-06
CHONGQING LUMMY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dosage is relatively large, and due to the single dosage form, it cannot meet the clinical needs
At present, there is no report on solving the mouthfeel problem of donkey-hide gelatin raw materials

Method used

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  • Donkey-hide gelatin oral preparation and its making method
  • Donkey-hide gelatin oral preparation and its making method
  • Donkey-hide gelatin oral preparation and its making method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 The preparation of donkey-hide gelatin oral liquid of the present invention

[0018] Dissolve 1 kg of donkey-hide gelatin in 10 L of phosphate buffer, adjust the pH to 7.0-7.5, add 2% alkaline protease, and perform enzymatic hydrolysis at 55° C. for 4 hours. During the enzymatic hydrolysis, keep stirring and keep the pH constant. After the first enzymatic hydrolysis, heat and boil for 5 minutes to terminate the first enzymatic hydrolysis reaction. Adjust the pH to 5.0-5.5 and add 2% acid protease, react at 55°C for 4h, keep stirring constantly during this period, and keep the pH constant. After the reaction finished, boiled for 20 minutes, added 0.2% aspartame after cooling and stirred evenly, and the reaction solution passed through filter paper successively, 0.45 μm microporous membrane, 0.1 μm microporous membrane, 10KD ultrafiltration membrane (millpore company product, U.S. ), adjusted the pH to 6.8, bottled, and steam sterilized at 115°C.

Embodiment 2

[0019] Embodiment 2 The preparation of donkey-hide gelatin oral liquid of the present invention

[0020] Crush 500g of Cordyceps mycelium to 100 mesh, add 10L of phosphate buffer, adjust the pH to 8.0-8.5, add 1% trypsin and enzymolyze at 35°C for 5 hours, keep stirring during the enzymolysis and keep the pH constant. After the end, heat and boil for 5 minutes to terminate the reaction. Dissolve 1 kg donkey-hide gelatin in this enzymatic hydrolysis solution and adjust the pH to 7.0-7.5, add 2% alkaline protease and perform enzymatic hydrolysis at 55° C. for 4 hours. During the enzymatic hydrolysis, keep stirring and keep the pH constant. After the first enzymatic hydrolysis, heat and boil for 5 minutes to terminate the first enzymatic hydrolysis reaction. Adjust the pH to 5.0-5.5 and add 2% acid protease, react at 55°C for 4h, keep stirring constantly during this period, and keep the pH constant. After the reaction finished, boiled for 20 minutes, added 0.2% aspartame after ...

Embodiment 3

[0021] Embodiment 3 Preparation of pharmaceutical tablet of the present invention

[0022] After the reaction solution was prepared by the method of Example 2 of the present invention, a light yellow powder was obtained by a spray drier, 150g powder was added, 70g lactose, 5g sodium carboxymethyl starch were mixed uniformly, and 45ml2% carmellose aqueous solution was added Prepare soft material, granulate with 14 mesh sieve, dry at 65°C for 30 minutes, granulate with 16 mesh, add 5g sodium carboxymethyl starch and 1g magnesium stearate at the same time, mix evenly, measure the content, and press into tablets .

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PUM

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Abstract

An orally taken donkey-hide gelatin product is prepared from donkey-hide gelatin through enzymolyzing to obtain polypeptide, and mixing with the pharmacologically acceptable auxiliary.

Description

technical field [0001] The invention relates to an oral preparation of donkey-hide gelatin, specifically, an oral preparation prepared from donkey-hide gelatin as a raw material. Background technique [0002] Donkey-hide gelatin is derived from the depilated hide of the equine donkey Equus asinus Linnaeus, which is decocted and concentrated into a solid gelatin. Mainly produced in Shandong, Zhejiang, Hubei, Beijing, Tianjin, Liaoning. Harvested throughout the year. Its traditional preparation method is to soak the donkey skin, remove the hair, cut it into small pieces, then soak it and wash it, decoct it in water several times, filter it, combine the filtrate, and concentrate it with a slow fire (or add appropriate amount of rice wine, rock sugar, soybean oil) to Thick paste, condensed, cut into pieces, and dried in the shade. It is rectangular or square block, dark brown and shiny. The quality is hard and brittle, the cross-section is bright, and the fragments are brown...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/36A61K36/068A61K9/48A61K9/20A61K9/08A61P7/06A61P7/04
Inventor 唐小海邱宇丁平
Owner CHONGQING LUMMY PHARMA
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