Scanning laser device and methods of use

Abstract

In one aspect, the invention provides vision prosthesis systems. Exemplary vision prosthesis systems of the invention comprise a light energy generator operably connected to a wearable head piece comprising a device for directing light energy produced by the light energy generator onto a mammalian retina, wherein the light energy generator is tuned to emit light energy of sufficient power to modulate neural activity in the retina. In another aspect, the invention provides methods for irradiating neurons in the retina of the mammalian eye by directing light energy produced by a light energy generator onto a mammalian retina. The methods of the invention may be used to directly modulate the activity of retinal neurons or to introduce molecules into retinal cells.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims the benefit of U.S. Provisional Application No. 60 / 486,623, filed Jul. 11, 2003, under 35 U.S.C. § 119.STATEMENT OF GOVERNMENT LICENSE RIGHTS[0002]This invention was made with government support under 9978888 awarded by the National Science Foundation. The government has certain rights in the invention.FIELD OF THE INVENTION[0003]The present invention relates to methods and prosthetic apparatus for modulating neural activity and in particular to apparatus for producing an artificially-formed sense, such as vision.BACKGROUND OF THE INVENTION[0004]The mammalian eye includes a cornea, a fluid-filled anterior chamber, a lens, a fluid-filled posterior chamber, and a photosensitive retina. The designations “anterior” and “posterior” are with reference to the lens. Light enters the eye through the cornea, passes through the anterior chamber and is focused onto the retina by the lens. The retina is composed of numerous type...

AI Technical Summary

Benefits of technology

The invention provides vision prosthesis systems and methods for improving vision in mammals with damaged or diseased retinas. The systems comprise a light energy generator that emits light energy to modulate the activity of neurons in the retina. The light energy is directed onto the retina using a scanner and an ocular lens. The methods can be used to treat retinal degeneration or other retinal diseases. The light energy can be produced by a laser, diode, or other light source. The invention also provides methods for introducing molecules into retinal cells to promote their health and survival.

Problems solved by technology

In the condition known as retinitis pigmentosa, the rods degenerate first and result in loss of night vision, and later the cones degenerate, resulting in total blindness.

Due to the many applications of lasers and the increasing use in the military, laser eye injuries that destroy the retinal pigmented epithelium and light-sensitive photoreceptors are a growing problem (Barkana & Belkin (2000) Surv. Ophthalmol. 44(6):459-478).

There are currently no treatments for most eye injuries and diseases that cause the destruction and degeneration of photoreceptors.

Implanted electrode arrays have significant limitations, however, such as power dissipation, incompatibility with surrounding biological tissues, low density of photocells in the electrode arrays, and the lack of knowledge about the neural interconnections to the bipolar and ganglion cells, and the type of stimulation required to mimic retinal signal processing (Liu et al.

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