Topical zinc compositions and methods of use

Abstract

Compositions including zinc compounds and select amino acids in a carrier base, and methods of skin treatment with such compositions, are described. The compositions are useful for healing skin and minimizing the irritation incurred from contact with the zinc compound without loss of zinc availability during absorption into the integument.

Description

[0001] The present invention relates to zinc-containing compositions and methods for topical use of such compositions to treat cutaneous wounds, irritations, lesions, abrasions or the like. More particularly, the invention relates to zinc-containing compositions containing an amino acid to minimize external irritation from the zinc when applied to the skin without diminishing the amount of free zinc available for absorption.[0002] The value of zinc in tissue growth and repair is well documented. Zinc is essential for the function of at least 70 enzymes and is involved in a variety of metabolic processes. Zinc is a limiting factor in the formation of RNA and DNA. Zinc is also a limiting factor in zinc-dependent enzymes such as RNA and DNA polymerases, deoxythymidine kinase, and reverse transcriptase, which are responsible for the regulation of RNA and DNA metabolism. Diminished zinc availability slows protein synthesis, thereby slowing the replication of cells and inhibiting tissue r...

AI Technical Summary

Benefits of technology

[0020] Another object of the invention is to provide a topical zinc composition that supplies a high effective concentration of available zinc and minimizes skin irritation.

[0023] The composition of the present invention includes (1) a pharmaceutically acceptable zinc compound, preferably zinc oxide or a divalent zinc complex, (2) a select amino acid, preferably glycine, and (3) a pharmaceutically acceptable carrier base, such as a solid or semi-solid carrier base. The zinc compound is present in the carrier base together with a large excess of the amino acid (2 to 20 molar equivalents to the zinc) to provide a composition with high zinc ion availability and minimal skin irritance when topically applied to the skin.

Problems solved by technology

Diminished zinc availability slows protein synthesis, thereby slowing the replication of cells and inhibiting tissue repair.

Approximately half of the total body zinc content of 2-3 gm (based on an average 70 kg adult) is found in ossified tissues and is, therefore, not readily available for metabolic processes.

Although the skin boasts a higher zinc concentration than most tissues (10 micrograms / g of tissue), this is quickly depleted during the regeneration process.

Oral preparations of several zinc salts have been shown to reduce the symptoms and duration of the common cold caused by rhinovirus, but they are unpalatable and cause mouth irritation and nausea.

Unfortunately, topical application of some zinc solutions can cause painful or irritating side effects if not used in very low concentrations.

Zinc sulfate solutions of 0.2-1% can cause severe irritation, unpleasant dryness and stimulate the emetic reflex when applied circumorally.

Further, it is interesting to note that in other studies the zinc solutions, particularly of zinc sulfate, do not maintain constant local concentration levels when applied to the skin as does zinc oxide.

This further characterization, however, of quaternary ammonium compounds is in error.

Many existing topical formulations are inadequate because they produce such local irritation that they are not easily tolerated.

Others also frequently lack a sufficient effective concentration of zinc ion due to the low solubility of zinc oxide in the absence of suitable solubilizing agents.

Further, existing formulations have unpalatable tastes, making circumoral application impractical.