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Antigenic substance inductor, vaccine precursor, vaccine, antibody, neutralizing antibody, antitoxin, idiotype antibody and/or anti-idiotype antibody which is induced by its idiotype antibody

a technology of antigen-containing substances and antibodies, which is applied in the field of antigen-containing substances, vaccine precursors, antibodies, neutralizing antibodies, idiotype antibodies and/or anti-idiotype antibodies, which can solve the problem of quantitative thermodynamic disruption

Inactive Publication Date: 2002-01-24
KOYAMA SHOZO +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0061] Pharmaceutically permissible protecting substituents of carboxyl group with easily removal from body represents protecting carboxyl group such as esterized substituent.
[0069] ICOM (immunostimulating complex) which is embedded small granule with an identified chemical structure is also possible to enhance an antigenic property of antibody mentioned in this invention.

Problems solved by technology

This mechanism of fragmentation results from a quantum thermodynamic disruptive and fragmented effects of antigenic substance inductors.

Method used

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  • Antigenic substance inductor, vaccine precursor, vaccine, antibody, neutralizing antibody, antitoxin, idiotype antibody and/or anti-idiotype antibody which is induced by its idiotype antibody
  • Antigenic substance inductor, vaccine precursor, vaccine, antibody, neutralizing antibody, antitoxin, idiotype antibody and/or anti-idiotype antibody which is induced by its idiotype antibody
  • Antigenic substance inductor, vaccine precursor, vaccine, antibody, neutralizing antibody, antitoxin, idiotype antibody and/or anti-idiotype antibody which is induced by its idiotype antibody

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Embodiment Construction

[0099] Murine leukemic cells L-1210 (Cancer research institute, Tokyo) was incubated with 2 ml of culture medium (Minimum Essential Medium, Gibco Co.) including bovine fetus serum (Dai-Nipon Pharmace. Co.) at a temperature of 37.degree. C. and 5% CO.sub.2 for 30 hours in the incubator. When a number of cells becomes to around 1.times.10.sup.6 / ml, cell death is induced by an addition of 4 .mu.l of 2M Yoshixol in ethanol. As a result, a determination of cell viability due to an uptake of methylene blue showed a survival cell of 5.times.10.sup.4 at 2 hours after Yoshixol, closely zero level after 20 hours and zero after 30 hours. After confirming extinction of cells in culture medium, the culture medium of which contains extincted cells was centrifuged at 3,000 cycles / min for 5 minutes so that it's supernant was removed. After adding physiological saline of 0.9 cc into the sedimented component and stirring, a centrifuging separation was performed at 1,000 cycles / min for 5 minutes. This...

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Abstract

This invention provides antigen substance inductors which produce highly selective and / or specific vaccine precursor, vaccine, antibody (including idiotype antibody), neutralizing antibody, antitoxin. This invention is to produce and / or manufacture highly selective and / or specific vaccine precursor, vaccine, antibody (including idiotype antibody), neutralizing antibody, antitoxin by quantum thermodynamic and chemical control of molecular functions and morphogenesis, inducing non-functional complex macromolecules which form organism and / or non-organism and which become to be substance with fundamental structure more closed to an induction of the functions, utilizing the fundamental structure of molecule which is indicated in Formula 3-a as a representative molecule. Moreover, by those produced substances, this invention is to produce and / or manufacture antimicrobial agent, antiviral agent, neutralizing antibody, antitoxin, antitumor agent, anti-protozoa agent (malaria, spirochaeta et. al), molecular discriminating agent, antibody as labeled compounds, histocompatible accelerator on tissues or organs, immuno-response accelerator or immuno-response controller, complement chain reaction accelerator.

Description

[0001] This invention concerns vaccine precursor, vaccine, antibody, neutralizing antibody, antitoxin or idiotype antibody of which is able to discriminate substrates (lipid, carbohydrate, amino acid and so on) of less than molecular weight of 10,000. Such substrates consist of fundamentally morphological structure and / or physiological function and those form complex macromolecules of which are induced species-specific morphological and functional diversity. Either vaccine precursor, vaccine, antibody, neutralizing antibody, antitoxin or idiotype antibody is constituted by macromolecules substance more than one macromolecule. Also, this invention concerns vaccine precursor, vaccine, antibody, neutralizing antibody, antitoxin or the idiotype antibody induced by its idiotype antibody of which was mentioned above. In addition, this invention concerns anti-microbial agent, antiviral agent, anti-tumor agent, anti-protozoa agent (malaria, spirochaeta et. al), antitoxin, antibody of non-bi...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/122A61K39/385
CPCA61K31/122Y10T436/200833A61K2039/6012A61K39/385Y02A50/30
Inventor KOYAMA, SHOZOTANAKA, SATOSHI
Owner KOYAMA SHOZO
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