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Radiation resistant composition

A composition and anti-radiation technology, applied in drug combination, drug delivery, pill delivery, etc., can solve the problems of free radical damage to protein, free radical damage, free radical damage to lipids, etc., to achieve good mutual promotion and synergy The effect of action

Inactive Publication Date: 2007-05-16
北京燕京中科生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 2. Free radical damage to protein
[0010] 3. Free radical damage to carbohydrates
[0012] 4. Free radical damage to lipids
In addition, phospholipids rich in polyunsaturated fatty acids are important components of various biological membranes. If these membrane lipids undergo peroxidation, it will lead to cross-linking and inactivation of proteins and enzymes in the membrane, which will change the permeability of the membrane. , thereby affecting the physiological functions of cell membranes, such as damage to mitochondrial membranes will lead to reduced energy production

Method used

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  • Radiation resistant composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The composition of embodiment 1 composition of the present invention

[0028] Table 1 is the formulation of the composition of the present invention by weight percentage, wherein the 5'-nucleotide can be 5'-adenosine monophosphate, 5'-guanosine monophosphate, 5'-cytidine monophosphate, 5'-uridine monophosphate, or any combination thereof.

[0029] The formula of table 1 composition of the present invention

[0030] formula

[0031]The composition contains the three ingredients in the above weight percentages, and the rest can be mixed with medically or food-acceptable carrier substances to prepare various dosage forms. For example, adding an appropriate amount of starch and fully mixing to prepare dry powder.

Embodiment 2

[0032] Embodiment 2 function identification

[0033] 1 Experimental operation steps

[0034] ① The formula of the anti-radiation composition is formula 1 in Example 1. The low-dose group used the composition at 200 mg / kg.bw, and the high-dose group used the composition at 400 mg / kg.bw.

[0035] ② Experimental animals: Kunming 1-month-old second-grade female mice (SCXK (Beijing) 2002-001) provided by the Experimental Animal Center of the Chinese Academy of Military Sciences were selected and divided into two batches, and the mice were randomly divided into groups. Experiments on two indicators of serum hemolysin and superoxide dismutase activity were carried out.

[0036] ③Reagents: Sheep red blood cells (SRBC), guinea pig serum, normal saline, SA buffer, ethanol, chloroform, Dushi's reagent, superoxide dismutase kit.

[0037] ④Radiation animal model: After 30 days of intragastric administration of the tested mice, the mice undergoing the serum hemolysin test were treated wi...

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Abstract

The invention relates to an anti-radiation compound, wherein it comprises 5'-nucleotide at 10-30%, vitamin C at 5-15%,and soybean oligosaccharide at 20-40%, while its serolysin HC50 and hyperoxide dismutation enzyme activity are improved (p<0.05); and the user weight and other indexes have no significant difference (p>0.05).

Description

technical field [0001] The invention relates to the field of health food, in particular to an anti-radiation damage composition containing mononucleotide. Background technique [0002] Due to the development of economy and the modernization of cities, the electromagnetic environment of cities in our country is becoming more and more complex. Some experts pointed out that man-made electromagnetic energy in urban space will increase at a rate of 7-14% per year, and by 2000 the urban environmental electromagnetic energy density will increase by a maximum of 26 times compared with the 1970s. For each family, the types and quantities of household appliances are constantly increasing, but household appliances such as computers, TVs, refrigerators, microwave ovens, and mobile phones bring a lot of electromagnetic radiation while bringing convenience to people; With the development of medical and health services, the frequent application of radiotherapy and large-scale inspection e...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K9/08A61K9/10A61K9/14A61K9/20A61K9/48A61P17/16A61P43/00A61K31/375A61K31/7052
Inventor 赵红玲贾乃堃刘朵花黎高沃
Owner 北京燕京中科生物技术有限公司
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