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Blood sugar regulator used during user having meals and its preparation method

A technology for regulating agent and blood sugar, which is applied in the directions of antidote, medical preparations containing active ingredients, digestive system, etc., can solve the problems of lack of market competitiveness and high price, achieve good timing of taking medicine, good protective effect, and improve preparation yield. rate effect

Inactive Publication Date: 2010-09-22
王京杭
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the GXM prepared by this process is used for the mealtime blood sugar regulator of the present invention, the price is higher and lacks market competitiveness

Method used

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  • Blood sugar regulator used during user having meals and its preparation method
  • Blood sugar regulator used during user having meals and its preparation method
  • Blood sugar regulator used during user having meals and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] GXM separation and purification

[0052] Commercially available Tremella fruiting bodies (dry) were pulverized into fine powder. Add tap water and white fungus powder into the reaction tank at a weight ratio of 20:1 (w / w), heat it to 140°C under stirring and keep it for 3 hours, then stop heating. After cooling, deflate, open the tank and discharge, centrifuge to take the supernatant, add 4 times the volume of 95% edible ethanol to precipitate it under stirring, centrifuge to take the precipitate, add 10 times the weight of water to dissolve, and centrifuge to take the clarified liquid. The molecular weight is 10KD) concentrated, repeated ultrafiltration and washing several times, and the concentrated solution was spray-dried to make GXM dry powder.

[0053] The process of preparing GXM from the fermentation broth of Tremella fungus strains can also be carried out with reference to this method. GXM components with different molecular weights can be obtained by hydroly...

Embodiment 2

[0059] Preparation of GXM Granules

[0060] According to the prescription design requirements, mix the GXM dry powder that meets the quality standards and the sweetener powder (such as stevioside) at a ratio of 100:1 (w / w), and then quantitatively distribute 5g of GXM in each bag into composite aluminum foil bags , after being sealed, the mealtime blood sugar regulating agent product can be obtained. If the original flavor of GXM granules is prepared, sweeteners and other auxiliary materials may not be added. If GXM multivitamin granules are prepared, the required vitamins can be added according to the prescription.

[0061] The production process of the product should be carried out in accordance with the relevant requirements of the national drug or food regulations. For those skilled in the field of pharmaceutical or food production, the preparation process is a conventional technique.

Embodiment 3

[0063] Effect of GXM on Postprandial Blood Glucose in Mice

[0064] Take 50 normal Kunming mice (male), weighing 20±2g / mouse. Randomly grouped, 10 in each group. The mice were fasted (drinking water freely) overnight, blood was collected from the tail of the next day to measure fasting blood glucose (FBG), and then 0.40 ml of food was given by intragastric administration. The food of the control group is: 12.5% ​​(W / v) refined powder suspension (starch has been heated and gelatinized), and the dose is equivalent to 2.5g / kg; the food composition of the GXM test group is: GXM+12.5% ​​(W / v) refined powder pink. GXM has three types of high, medium and low molecular weight (HMW, MMW, LMW). Detect blood glucose at 0.5, 1, and 2 hours after gavage. The blood glucose detector is SmartScan (produced by Johnson & Johnson, USA).

[0065] result:

[0066] Table 2. Effect of GXM on postprandial blood glucose in normal mice:

[0067]

[0068] (Note: * , p** , p*** , p<0.001)

[...

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Abstract

A blood sugar regulator applied on dining, a process for preparing lignomannosan gluconate, and its application in regulating blood sugar, decreasing blood sugar and blood fat, losing weight and preventing ulcer and constipation are disclosed.

Description

field of invention [0001] The invention relates to a mealtime blood sugar regulator with glucomannan as an active ingredient and its application in the field of diabetes prevention and health care, as well as a preparation process and application of glucosymannan. Background technique [0002] Diabetes Mellitus (DM) is a chronic endocrine and metabolic disease caused by the lack or relative lack of insulin in the human body. There are protein and fat metabolism abnormalities. Uncontrolled hyperglycemia is the main factor leading to a series of complications in diabetic patients, which not only brings great pain to patients, seriously reduces the quality of life, and even endangers life, but also brings heavy economic burden to the society. Diabetes has a high incidence and great harm, and patients often need to take medicine for life. Therefore, diabetes drugs not only need to be efficient and safe, but also need to have high economic efficiency, convenience and compliance...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61P3/04A61P3/06A61P3/10A61P1/04A61P1/10A61P11/00A61P17/16A61P35/00A61P37/02A61P39/06
Inventor 王京杭
Owner 王京杭
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