Gastrodine tablets disintegrating in oral cavity and process for producing same

A technology for oral disintegrating tablets and gastrodin, which is applied in the field of gastrodin oral disintegrating tablets and preparation thereof, can solve the problems of reducing the patient's treatment compliance and the like, and achieves improved use compliance, rapid dissolution and good operability. Effect

Active Publication Date: 2007-03-07
北京科信聚润医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The oral solid preparation of gastrodin needs to be swallowed with water, which brings a lot of inconvenience to patients who are busy with work or have difficulty swallowing, and reduces the compliance of patients to treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: gastrodin orally disintegrating tablet

[0035] 1. Preparation prescription

[0036] Gastrodin 50.0g

[0037] Polyacrylic resin IV 10.0g

[0038] Eudragit  NE30D 1.0g

[0039] Ethyl cellulose 10.0g

[0040] Micro Silica Gel 5.4g

[0041] Low Substituted Hydroxypropyl Fiber 6.0g

[0042] Cross-linked polyvinylpyrrolidone 8.0g

[0043] Microcrystalline Cellulose 10.0g

[0044]Mannitol 80.0g

[0045] Aspartame 2g

[0046] Orange essence 2g

[0047] Magnesium Stearate 1.5g

[0048] Appropriate amount of PVP-K30

[0049] Proper amount of ethanol solution

[0050] Makes 1000 pieces

[0051] 2. Description of prescription composition

[0052] Gastrodin: the main drug

[0053] Polyacrylic resin IV, Eudragit  NE30D, ethyl cellulose: coating materials

[0054] Micro-Silicone: Glidant

[0055] Mannitol, Microcrystalline Cellulose: Diluents

[0056] Low-substituted hydroxypropyl fiber, cross-linked polyvinylpyrrolidone: disintegrant

[0057] Asp...

Embodiment 2

[0066] Embodiment 2: gastrodin orally disintegrating tablets

[0067] According to the same method as in Example 1, wherein the disintegrating agent low-substituted hydroxypropyl fiber and cross-linked polyvinylpyrrolidone are in equal amounts, an orally disintegrating tablet is prepared.

[0068] The orally disintegrating tablets prepared in the above examples all have good mouthfeel and suitable hardness. After the stability test, the result also shows that it has good stability and meets the preparation requirements.

Embodiment 3

[0069] Embodiment 3: Detection of disintegration time limit

[0070] The research on the influence of temperature on the disintegration time shows that the temperature has an influence on the determination, and the disintegration is accelerated when the temperature rises. 37°C is close to the oral temperature, so 37°C is selected for the determination of the disintegration time limit.

[0071] The correlation study of the measurement method shows that the tentative method of measuring the disintegration time of the orally disintegrating tablet in the minutes of the second meeting has some shortcomings. First, the disintegration of the tablet is easy to judge when it is static, but the The end time is difficult to determine. During disintegration, the tablet disintegrates and accumulates on the surface of the undisintegrated core, and it is impossible to determine when the disintegration ends. Second, there is a large difference between the measured results of disintegration t...

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PUM

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Abstract

The invention relates to a gastrodine mouse mouse disintegration tablet, which uses gastrodine as main drug, with gastrodine coat capsule, diluter, and disintegrator. Wherein, the invention is characterized in that: said capsule is made from gastrodine, coated by acrylic acid resin and acrylic acid; and the disintegrator is low-replace hydroxypropyl cellulose and crosslink polyvinyl pyrrolidon. The invention has better disintegration time limit, with uniform solution.

Description

technical field [0001] The invention relates to a gastrodin orally disintegrating tablet and a preparation method thereof. Gastrodin has sedative, anticonvulsant, antiepileptic, analgesic, increases cerebral blood flow, improves vertebrobasilar artery, anterior inferior cerebellar artery, posterior inferior cerebellar artery, labyrinthine artery and insufficient blood supply in the ear, protects nerve cells, and promotes myocardial cell energy The function of metabolism is widely used in clinical practice. It belongs to the field of medicine. Background technique [0002] Gastrodin is the main component of the precious medicinal material Gastrodia elata. It has sedative, anticonvulsant, antiepileptic, analgesic, increases cerebral blood flow, improves vertebrobasilar artery, anterior inferior cerebellar artery, posterior inferior cerebellar artery, labyrinthine artery and insufficient blood supply in the ear. It protects nerve cells and promotes the energy metabolism of ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K9/20A61K31/7034A61P9/00A61P25/00
Inventor 王锦刚蒋海松
Owner 北京科信聚润医药科技有限公司
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